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 Showing 1-20 of 94 Articles
Editorial  FREE
Hans Christian Wulf, MD, DMSc, PharmD

In conventional photodynamic therapy (PDT) for the treatment of actinic keratoses (AK), 5-aminolevulinic acid (ALA) or methyl aminolevulinate (MAL) is applied to the skin after gentle curettage and stays there for a defined period of time (often 3 hours) to ensure accumulation of protoporphyrin IX (PpIX).1 During ...

Original Investigation  FREE
Amit Garg, MD; Justin Besen, MD; Aaron Legler, MPH; Christina S. Lam, MD

Importance  Studies evaluating factors associated with disease severity in hidradenitis suppurativa (HS) are limited, and the existing data are controversial. It is also unclear whether severity assessed by HS scoring methods correlate with partnered decision-making on treatment strategies, and thus the clinical relevance of these severity assessments ...

Original Investigation  FREE
Susan M. O’Gorman, MBBCh; Julianne Clowry, MBBCh; Michael Manley, MSc; Jackie McCavana, MSc; Linda Gray, MSc; Ann Kavanagh, BSc; Aoife Lally, MD; Paul Collins, MD
Includes: Supplemental Content

Importance  Daylight photodynamic therapy using topical methyl 5-aminolevulinic acid (MAL) for actinic keratoses (AKs) is as effective as conventional photodynamic therapy but has the advantage of being almost pain free. Daylight photodynamic therapy, however, requires dry and warm weather conditions.

Objective  To establish if topical MAL ...

Editorial: Photodynamic Therapy in Daylight; Hans Christian Wulf, MD, DMSc, PharmD
JAMA Dermatology Clinicopathological Challenge 
Asuka Tsuji, MD; Akane Minagawa, MD, PhD; Ryuhei Okuyama, MD, PhD

A man presented with a 3-year history of recurring erythematous papules on the bilateral cheeks, despite topical steroid therapy, without any additional symptoms. Polyclonal hypergammaglobulinemia was found on serum protein electrophoresis. What is your diagnosis?

Research Letter 
Aaron J. Blashill, PhD; Jessica L. Oleski, MA; Rashelle Hayes, PhD; Jonathan Scully, BS; Tad Antognini, MD; Effie Olendzki, MS, MBA; Sherry Pagoto, PhD

This study assesses the prevalence of seasonal affective disorder, perceived stress, and body dysmorphic disorder in women who frequently use indoor tanning.

Observation 
Tarek Yamany, MD; Bobby Y. Reddy, MD; Sameera Husain, MD; Marc E. Grossman, MD

This case report describes recurrent Richter’s transformation presenting with a penile ulcer.

Editorial 
Gery P. Guy Jr, PhD, MPH; Meg Watson, MPH; Lisa C. Richardson, MD, MPH; Boris D. Lushniak, MD, MPH

The incidence of melanoma has been rapidly increasing in the United States. Since exposure to UV radiation from indoor tanning is preventable, reducing exposure is an important strategy for melanoma prevention.1 The article by Lazovich et al2 in this issue of JAMA Dermatology provides an in-depth ...

Editorial 
Jouni Uitto, MD, PhD; Hassan Vahidnezhad, MSc; Leila Youssefian, MSc

Epidermolysis bullosa (EB) comprises a clinically heterogeneous group of disorders characterized by fragility of skin, leading to formation of blisters, erosions, and chronic ulcers. The cutaneous manifestations, together with extracutaneous complications, cause considerable morbidity and in some cases premature death.1,2 Epidermolysis bullosa is an orphan ...

Original Investigation 
DeAnn Lazovich, PhD; Rachel Isaksson Vogel, MS; Martin A. Weinstock, MD, PhD; Heather H. Nelson, PhD; Rehana L. Ahmed, MD, PhD; Marianne Berwick, PhD

Importance  In the United States and Minnesota, melanoma incidence is rising more steeply among women than men younger than 50 years. To our knowledge, no study has examined age- and sex-specific associations between indoor tanning and melanoma to determine if these trends could be due to greater ...

Editorial: Reducing Indoor Tanning ; Gery P. Guy Jr, PhD, MPH; Meg Watson, MPH; Lisa C. Richardson, MD, MPH; Boris D. Lushniak, MD, MPH
Original Investigation 
Alexander Egeberg, MD, PhD; Peter R. Hansen, MD, PhD, DMSci; Gunnar H. Gislason, MD, PhD; Jacob P. Thyssen, MD, PhD, DMSci
Includes: Supplemental Content

Importance  Rosacea, a common facial skin disorder, has a poorly understood pathogenesis in which increased matrix metalloproteinase activity might play an important role. Glioma accounts for 80% of all primary malignant tumors in the central nervous system, and these tumors also show upregulation of certain matrix metalloproteinases....

Case Report/Case Series 
Iana Turcan, MD; Anna M. G. Pasmooij, PhD; Peter C. van den Akker, MD, PhD; Henny Lemmink, PhD; Gyorgy B. Halmos, MD, PhD; Richard J. Sinke, PhD; Marcel F. Jonkman, MD, PhD

Importance  Epidermolysis bullosa (EB) is a group of mechanobullous genodermatoses characterized by the fragility of skin and mucous membranes. Mutations in the ITGA6 and ITGB4 genes, encoding the hemidesmosomal protein α6β4-integrin, have been involved in the pathogenesis of EB. To date, the inheritance ...

Editorial: Genotype and Inheritance in Epidermolysis Bullosa; Jouni Uitto, MD, PhD; Hassan Vahidnezhad, MSc; Leila Youssefian, MSc
JAMA Dermatology Clinicopathological Challenge 
Mona Ascha, BS; Mahwish Irfan, MD; Melissa Piliang, MD

A 50-year-old woman presented with a slowly progressive red to brown pruritic hyperkeratotic papules and reticulated hyperpigmentation involving her face, neck, chest, back, and upper and lower extremities; she had been previously diagnosed with Darier disease. What is your diagnosis?

Research Letter 
Joshua D. Fox, BS; Katherine L. Baquerizo-Nole, MD; Jeremy B. Freedman, BA; Sophia Liu, BS; Freya Van Driessche, MD; Elizabeth Yim, MD; Robert S. Kirsner, MD, PhD

This pilot study examines the effectiveness of compression therapy in treating pain, neuropathy, and reduced ankle range of motion in patients with venous leg ulcers.

Observation 
Weston Wall, BS; Caren Campbell, MD; Soon Bahrami, MD; Cindy Owen, MD

This case report describes the cutaneous presentation of methicillin-resistant Staphylococcus aureus sepsis in a healthy child.

Original Investigation 
Pritesh S. Karia, MPH; Jamil R. Azzi, MD; Eliot C. Heher, MD; Victoria M. Hills, BA; Chrysalyne D. Schmults, MD, MSCE
Includes: Supplemental Content

Importance  Solid-organ transplant recipients (OTRs) are at an increased risk for skin cancer. Prior studies have demonstrated a reduced incidence of skin cancer in renal OTRs treated with sirolimus. However, little information exists on the use of sirolimus for the prevention of skin cancer in nonrenal OTRs ...

Original Investigation 
Cristián Navarrete-Dechent, MD; Shirin Bajaj, BA; Michael A. Marchetti, MD; Harold Rabinovitz, MD; Stephen W. Dusza, DrPH; Ashfaq A. Marghoob, MD

Importance  Basal cell carcinoma (BCC) is the most common type of skin cancer and is usually nonpigmented. Shiny white structures (SWSs) are frequently present in BCC.

Objective  To determine the diagnostic accuracy of various morphologies of SWSs for diagnosis of nonpigmented BCC.

Design, Setting, and Participants...

JAMA Dermatology Clinicopathological Challenge 
William E. Damsky, MD, PhD; Brittany G. Craiglow, MD; Jaehyuk Choi, MD, PhD

A male neonate born prematurely at 27 weeks’ gestational age had a erythematous eruption at birth, exhibiting 100 to 200 pink papules, 0.05 to 0.2 cm in size, distributed on the trunk, extensor upper arms, and upper legs. What is your diagnosis?

Research Letter 
Mariya Miteva, MD; Mariana Lima, MD; Antonella Tosti, MD

This study reviews the trichoscopic images in the scalps of elderly women and assesses them for dirty dots.

Research Letter 
Myra A. Sendelweck, ME; Eric Bell, MPH; Amy Marie Anderson, MPH; Kurt Ashack, BA; Talia Pindyck, MD; Cate Townley, MURP, MUD; Robert P. Dellavalle, MD, PhD, MSPH

This study analyzes results from a survey of Colorado high school students to examine state-level associations between substance use and indoor tanning.

Observation 
Ian D. Odell, MD, PhD; Evelyn Lilly, MD; Katharine Reeve, DPM; Marcus W. Bosenberg, MD, PhD; Leonard M. Milstone, MD

This case report describes well-differentiated syringofibrocarcinoma in a patient with Clouston syndrome.

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