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 Showing 1-20 of 69 Articles
Editorial 
Mehdi Rashighi, MD; John E. Harris, MD, PhD

In this issue of JAMA Dermatology, Speeckaert and colleagues1 report that levels of the soluble CD25 and CD27 molecules (sCD25 and sCD27) are elevated in the serum of patients with active vitiligo compared with patients with stable disease. In addition, sCD25 levels were found to be ...

Original Investigation  FREE
Reinhart Speeckaert, MD, PhD; Jo Lambert, MD, PhD; Nanja van Geel, MD, PhD

Importance  It is difficult to determine disease activity in vitiligo owing to the absence of inflammatory signs, such as erythema or scaling. A biomarker that could confirm active disease and indicate likely future disease progression would therefore be of considerable value.

Objective  To investigate whether soluble ...

Original Investigation  FREE
Bobbak Mansouri, MD; Dario Kivelevitch, MD; Balaji Natarajan, MD; Aditya A. Joshi, MD; Caitriona Ryan, MD; Katie Benjegerdes, BS; Jeffrey M. Schussler, MD; Daniel J. Rader, MD; Muredach P. Reilly, MBBCH, MSCE; Alan Menter, MD; Nehal N. Mehta, MD, MSCE
Includes: Supplemental Content

Importance  Psoriasis is associated with an increased risk of cardiovascular diseases. Subclinical atherosclerosis in patients with psoriasis has not been compared with other conditions associated with increased cardiovascular risk and more rigorous cardiovascular disease screening, such as type 2 diabetes.

Objective  To assess the burden of ...

JAMA Dermatology Clinicopathological Challenge 
Dustin Y. Yoon, MD; Melanie A. Clark, MD; Heron E. Rodriguez, MD

A woman in her 30s had discrete clustered painful blue papules on her face and extremities; the lesions had been present since childhood, but the size and intensity of pain had recently increased. What is your diagnosis?

Original Investigation 
Nathaniel H. Fleming, BA; Barbara M. Egbert, MD; Jinah Kim, MD, PhD; Susan M. Swetter, MD

Importance  Controversy persists regarding the appropriate management of incompletely excised, biopsy-proven, mild and moderate dysplastic nevi (DN).

Objective  To determine long-term risk of associated melanoma in biopsied mild or moderate DN with positive histologic margins that were clinically observed vs reexcised with negative margins.

Design, Setting, ...

Original Investigation 
Eulalia Baselga, MD; Esther Roe, MD; Julien Coulie, MD; Fania Z. Muñoz, MD; Laurence M. Boon, MD; Catherine McCuaig, MD; Angela Hernandez-Martín, MD; Ignasi Gich, MD; Luis Puig, MD

Importance  Infantile hemangiomas involute to some extent, but they often leave sequelae that may cause disfigurement. Factors determining the risk of permanent sequelae after regression are of crucial importance in treatment decision making.

Objectives  To describe the sequelae left by infantile hemangiomas after natural involution and ...

Brief Report 
Jorre S. Mertens, MD; Manon C. Zweers, MD, PhD; Wietske Kievit, PhD; Hanneke K. A. Knaapen, MD; Martijn Gerritsen, MD, PhD; Timothy R. D. J. Radstake, MD, PhD; Frank H. J. van den Hoogen, MD, PhD; Marjonne C. W. Creemers, MD, PhD; Elke M. G. J. de Jong, MD, PhD
Includes: Supplemental Content

Importance  Eosinophilic fasciitis (EF) is a connective tissue disorder in which conventional treatment leads to disappointing results in a proportion of patients. Therefore, we investigated high-dose intravenous (IV) pulse methotrexate (MTX) as a treatment for EF.

Objective  To examine safety and effects of monthly high-dose IV ...

JAMA Dermatology Clinicopathological Challenge 
Adam S. Aldahan, BS; Alyx C. Rosen, MD; Shasa Hu, MD

A man in his 20s presented with a large, verrucous plaque on his right calf; the lesion initially appeared as a small, bluish plaque at a young age and had gradually increased in size with subsequent development of wart-like features. What is your diagnosis?

Original Investigation 
An-Wen Chan, MD, DPhil; Kinwah Fung, MSc; Jennifer M. Tran, MD; Jessica Kitchen, MEpi; Peter C. Austin, PhD; Martin A. Weinstock, MD, PhD; Paula A. Rochon, MD, MPH
Includes: Supplemental Content

Importance  Keratinocyte carcinoma (nonmelanoma skin cancer) accounts for substantial burden in terms of high incidence and health care costs but is excluded by most cancer registries in North America. Administrative health insurance claims databases offer an opportunity to identify these cancers using diagnosis and procedural codes submitted ...

Original Investigation 
Michael J. Bax, MD; Timothy M. Johnson, MD; Paul W. Harms, MD, PhD; Jennifer L. Schwartz, MD; Lili Zhao, PhD; Douglas R. Fullen, MD; May P. Chan, MD

Importance  It is unclear why some patients with in situ melanoma develop metastases. Few reports demonstrate occult invasion with immunohistochemistry staining, which were discordant with reports interpreting such staining as false-positive.

Objective  To investigate the occurrence of occult invasive disease within in situ melanoma by using ...

JAMA Dermatology Clinicopathological Challenge 
W. C. Cole Claiborne, MD, MPH; Ashley E. Morgan, MD; Andrea Tesvich Murina, MD

An African American woman in her 30s with no medical history presented with a 4-year history of diffuse progressive proliferation of dark papules with first onset several weeks after a sunburn. What is your diagnosis?

Observation 
Eseosa Asemota, MD, MPH; Yunyoung Claire Chang, MD; Lynne J. Goldberg, MD

This case report describes the use of an innovative technique to manage recalcitrant dissecting cellulitis.

Original Investigation 
Jerry D. Brewer, MD; Alexandra B. Gonzalez, MD; Christian L. Baum, MD; Christopher J. Arpey, MD; Randall K. Roenigk, MD; Clark C. Otley, MD; Patricia J. Erwin, MLS
Includes: Supplemental Content

Importance  Whether the use of sterile vs nonsterile gloves in outpatient cutaneous procedures affects the rate of postoperative wound infection is unknown.

Objective  To explore rates of surgical site infection (SSI) with the use of sterile vs nonsterile gloves in outpatient cutaneous surgical procedures.

Data Sources...

Brief Report 
Béatrice Vergier, MD, PhD; Elodie Laharanne, PhD; Martina Prochazkova-Carlotti, PhD; Arnaud de la Fouchardière, MD; Jean-Philippe Merlio, MD, PhD; Natacha Kadlub, MD; Marie-Françoise Avril, MD; Christine Bodemer, MD; Caroline Lacoste, MD; Franck Boralevi, MD, PhD; Alain Taieb, MD, PhD; Khaled Ezzedine, MD, PhD; Sylvie Fraitag, MD
Includes: Supplemental Content

Importance  The differential diagnosis between proliferative nodules (PNs) and melanoma arising in congenital melanocytic nevi (CMN) is crucial, as patients with PNs most often experience no increased risk of melanoma with metastases and death.

Objective  To analyze the utility of immunohistochemistry and fluorescence in situ hybridization ...

JAMA Dermatology Clinicopathological Challenge 
Shari R. Lipner, MD, PhD; Richard K. Scher, MD, FACP

A man in his 70s presented with a split in the right fifth fingernail with paroxysmal, intermittent pain that was exacerbated by cold weather for the past 10 years. What is your diagnosis?

Observation 
Allison Zarbo, MD; Ouathek Ouerfelli, PhD; Mark Klang, PhD; Mario E. Lacouture, MD

This case report describes an incident of increased airport scrutiny by the Transportation Security Administration of a patient-passenger carrying ammonium lactate–containing moisturizer.

Importance  Accurate estimation of the incidence and prevalence of each subtype of epidermolysis bullosa (EB) is essential before clinical trials can be designed and sufficient funding allocated by government agencies and third-party insurers for the care of these individuals.

Objective  To determine the incidence and prevalence ...

Original Investigation 
Alexander Kreuter, MD; Christos Siorokos, MD; Frank Oellig, MD; Steffi Silling, PhD; Herbert Pfister, PhD; Ulrike Wieland, MD
Includes: Supplemental Content

Importance  Human papillomavirus (HPV)-induced anogenital lesions are very frequent in men who have sex with men (MSM) who are HIV-positive (HIV+). Anogenital warts (AGWs) are considered benign lesions caused by low-risk HPV-types, whereas anogenital dysplasias are potential cancer precursors associated with high-risk HPV-types. Both types of lesions ...

Research Letter 
Marie Perier-Muzet, MD; Amélie Boespflug, MD; Nicolas Poulalhon, MD; Julie Caramel, PhD; Anne-Laure Breton, MD; Luc Thomas, MD, PhD; Stephane Dalle, MD, PhD

This observational study investigates nevi changes after combined BRAF inhibitor and mitogen-activated protein kinase pathway inhibitor therapy in patients with metastatic melanoma.

Observation 
Chi-Feng Yen, MD; Hung-Bun Lam, MD

This case report describes the use of CMF chemotherapy to treat triple-negative breast cancer with carcinoma erysipelatoides.

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