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 Showing 1-20 of 91 Articles
Case Report/Case Series 
Curtis Lamar Hardy, DO; Jonathan S. Glass, MD; Timothy Sorrells, MD; Luke C. Nicholas, MD

Importance  The breakdown of previously inserted intravascular devices can lead to microemboli that can clinically mimic the symptoms of common disorders, such as senile purpura, and have subtle histologic findings. However, device failure can occur gradually and start months after placement. If not identified early, microemboli to ...

The Cutting Edge 
Michael Kasperkiewicz, MD; Sven Süfke, MD; Enno Schmidt, MD, PhD; Detlef Zillikens, MD
JAMA Dermatology Clinicopathological Challenge 
Michael Cunningham, MS; Ryan Rogers, MD; Laura Greene, MD
JAMA Dermatology Clinicopathological Challenge 
Amanda J. Tschetter, MD; Mary S. Stone, MD; Marta J. VanBeek, MD
Lola V. Stamm, PhD
This Viewpoint gives an overview of the mosquito-transmitted disease caused by the chikungunya virus, describes why it will likely become more common in the United States, and suggests several measures that can be taken to protect the US population from this emerging threat.
Research Letter 
Raja K. Sivamani, MD, MS, CAT; J. Eileen Morley, MD; Balvinder Rehal, MD, MAS; April W. Armstrong, MD, MPH
Includes: Supplemental Content
Previous studies suggest that people with skin diseases use complementary and alternative medicine (CAM)1,2; however, it is not known whether CAM was used specifically to treat their skin disease. We conducted a survey to determine differences in CAM use for skin diseases between patients attending dermatology clinics and those attending ...
Research Letter 
Sheila Krishna, MD; Jean-Phillip Okhovat, BS; Jenny Kim, MD, PhD; Christina N. Kim, MD
The effect of ω-3 fatty acid (ω-3FA) supplementation on triglyceride levels was assessed in a retrospective study of patients taking isotretinoin for acne. Oral isotretinoin (13-cis-retinoic acid) is commonly used in the treatment of severe and recalcitrant acne.1- 3 This treatment commonly results in complete clearance of acne with long-term ...
Charlotte Pernet, MD; Georges-Philippe Pageaux, MD, PhD; Bernard Guillot, MD, PhD; Olivier Dereure, MD, PhD; Didier Bessis, MD
Since its approval in 2011, a novel serine protease inhibitor, telaprevir, has been increasingly used in combination with pegylated interferon and ribavirin as an effective treatment for chronic hepatitis C virus (HCV) infection. However, it was found to cause cutaneous eruption, mostly pruritic eczematous dermatitis, in 56% of patients as ...
Maira Fonseca, BS; Michael A. Marchetti, MD; Maija H. Kiuru, MD; Ashfaq A. Marghoob, MD; Allan C. Halpern, MD
Cutaneous melanoma metastases can be categorized into satellite (≤2 cm from primary melanoma), in-transit (>2 cm from primary melanoma but not beyond the regional nodal basin), and distant metastases (>2 cm from primary melanoma and beyond the regional nodal basin). The presence of cutaneous melanoma metastases is a component of ...
Michael S. Graves, MD; Mary E. Hardin, BS; Loretta S. Davis, MD
Acrokeratosis paraneoplastica, or Bazex syndrome, is a unique cutaneous eruption associated with internal malignant conditions, most commonly squamous cell carcinoma of the aerodigestive tract. While classic stages and sites of involvement are most often reported, atypical presentations must not be overlooked.
Evelyn Lilly, MD; Matthew Burke, MBA, RN, MSN, APRN-BC; Harriet Kluger, MD; Jennifer Choi, MD
Cutaneous adverse effects are one of the most frequent adverse events (AEs) associated with the use of BRAF inhibitors, reported in 92% to 95% of patients.1 Such dermatologic reactions include maculopapular eruptions, photosensitivity, verrucous keratoses, keratosis pilaris–like eruptions, keratoacanthomas, and melanocytic proliferations.2 Hand-foot skin reaction (HFSR) occurs in 19% to ...
Frederick William Danby, MD, FRCPC
Dermatologists provide care for perimenopausal and menopausal women with hormone-related complaints: hair loss, acne climacterica, acne rosacea, acne inversa (hidradenitis suppurativa), dry skin, wrinkling, hirsutism, pruritus vulvae, and other vulvar dermatoses. The question, “Should I take hormone replacement therapy (HRT)?” is usually unspoken. The answer was complicated in 2002 by ...
Case Report/Case Series 
Vijay Zawar, MD, DNB, DVD, FAAD; Pravin Bharatia, MD; Antonio Chuh, MD, FRCP, FRCPCH
Includes: Supplemental Content

Importance  Recognition of different clinical presentations of viral and virally triggered (“paraviral”) exanthems is necessary for patients to be appropriately diagnosed and counseled.

Observations  Nine children presented with eruptions of hypopigmented macules following coryzal symptoms. Other diagnostic considerations, such as pityriasis alba, pityriasis versicolor, and progressive ...

Vanessa L. Pascoe, BA; Alexandra B. Kimball, MD, MPH
Hidradenitis suppurativa (HS) is a chronic, destructive, debilitating inflammatory skin disease characterized by recurrent, painful, deep-seated nodules and/or abscesses in intertriginous areas.1 It is also relatively common, with a reported prevalence as high as 1% to 4%.2,3 Nevertheless, HS has historically been an orphan disease, unclaimed by any specialty, owing, ...
Recent postmarketing studies and the US Food and Drug Administration have found that finasteride, 1 mg, for androgenic alopecia has been associated with persistent sexual and nonsexual adverse effects.1 The mechanisms of these symptoms in humans are unknown. Finasteride, 1 mg, has been associated with male infertility, and 5% of ...
Comment & Response 
Baotao Huang, MD; Ran Zhang, MBBS; Mao Chen, MD, PhD
To the Editor We greatly appreciated the article by Wu et al,1 which showed the independent association between long-term hypertension, long-term administration of β-blockers, and incident psoriasis in a large prospective cohort. However, although the study presented new evidence of the association, no management advice was proposed. How should patients ...
Original Investigation 
Iben Marie Miller, MD; Christina Ellervik, MD, PhD; Gabrielle Randskov Vinding, MD; Kian Zarchi, MD; Kristina Sophie Ibler, MD; Kim Mark Knudsen, PhD; Gregor B. E. Jemec, DMSc, MD
Includes: Supplemental Content

Importance  An association between the metabolic syndrome (MetS) and chronic inflammatory diseases, such as psoriasis or rheumatoid arthritis, has been suggested. Hidradenitis suppurativa (HS), a more localized chronic inflammation of the skin, has been speculated to have a similar association. Hidradenitis suppurativa is a substantial burden for ...

Original Investigation 
Henry W. Lim, MD; Pearl E. Grimes, MD; Oma Agbai, MD; Iltefat Hamzavi, MD; Marsha Henderson, MD; Madelaine Haddican, MD; Rita V. Linkner, MD; Mark Lebwohl, MD

Importance  Narrowband UV-B (NB–UV-B) phototherapy is used extensively to treat vitiligo. Afamelanotide, an analogue of α–melanocyte-stimulating hormone, is known to induce tanning of the skin.

Objective  To evaluate the efficacy and safety of combination therapy for generalized vitiligo consisting of afamelanotide implant and NB–UV-B phototherapy.

Design, ...

Lola V. Stamm, PhD
The discovery in July 2014 of 6 heat-sealed glass vials of the smallpox virus along with more than 300 vials of other viral and bacterial pathogens in a cold storage room at the National Institutes of Health campus (Bethesda, Maryland) has received only modest attention.1 Perhaps this is because most ...
Topics: smallpox
Case Report/Case Series  FREE
Iris Spoerri, PhD; Michela Brena, MD; Julie De Mesmaeker, PhD; Nina Schlipf, PhD; Judith Fischer, MD, PhD; Gianluca Tadini, MD; Peter H. Itin, MD; Bettina Burger, PhD
Includes: Supplemental Content

Importance  Ichthyosis with confetti (IWC) is a genodermatosis caused by dominant negative mutations in the gene encoding keratin 10 (KRT10). We investigated clinical and genetic details of a substantial number of patients with IWC in order to define major and minor criteria for diagnosis of ...

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