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 Showing 1-20 of 83 Articles
Case Report/Case Series 
Claudia Günther, MD; Nicole Berndt, MSc; Christine Wolf, MSc; Min Ae Lee-Kirsch, MD
Includes: Supplemental Content

Importance  Familial chilblain lupus is a rare, autosomal dominant form of lupus erythematosus characterized by cold-induced inflammatory lesions at acral locations presenting in early childhood. Familial chilblain lupus is usually caused by a mutation in TREX1 (3′ repair exonuclease 1).

Observations  We report on a family ...

April W. Armstrong, MD, MPH; Jerry Bagel, MD; Abby S. Van Voorhees, MD; Andrew D. Robertson, PhD; Paul S. Yamauchi, MD

Importance  While monotherapy with biologic agents is effective for many patients with psoriasis, some patients require combination therapy. Evidence-based recommendations on combination therapy provide guidance for treating appropriately selected patients with psoriasis.

Objective  To make evidence-based, best-practice recommendations regarding combining biologics with other systemic treatments, including ...

Elizabeth Yim, MPH; Robert S. Kirsner, MD, PhD; Robert S. Gailey, PhD, PT; David W. Mandel, PhD, PT; Suephy C. Chen, MD, MS; Marjana Tomic-Canic, PhD

Importance  Patients with venous leg ulcers (VLUs) have calf muscle pump dysfunction, which is associated with reduced ankle range of motion (ROM). Physical therapy or exercise that targets ankle joint mobility may lead to improvement in calf muscle pump function and subsequent healing. However, little is known ...

JAMA Dermatology Clinicopathological Challenge 
Karen Itumeleng Mosojane, MSV; Lara Wine Lee, MD, PhD; Carrie L. Kovarik, MD
Research Letter 
Martina Sanlorenzo, MD; Igor Vujic, MD; Christian Posch, MD; James E. Cleaver, PhD; Pietro Quaglino, MD; Susana Ortiz-Urda, MD, PhD
Recently, a meta-analysis reported an increased incidence of melanoma in pilots and cabin crew, which was possibly due to occupational exposures.1 Cabin crews’ exposure to cosmic radiation was assessed in different studies and always found below the allowed dose limit.2 However, the cumulative exposure of pilots and cabin crew to ...
Invited Commentary 
Joseph McCulloch, PT, PhD, CWS, FAPTA; Edward Mahoney, PT, DPT, CWS; Stanley McCallon, PT, DPT, CWS
The role of the calf muscle pump in addressing complications associated with ambulatory venous hypertension and venous leg ulcers (VLUs) has received a great deal of attention in recent years. Any serious look at the rehabilitation of individuals with calf muscle pump dysfunction should logically include the expertise of a ...
Brian J. Simmons, BS; Robert D. Griffith, MD; Leyre A. Falto-Aizpurua, MD; Keyvan Nouri, MD
Envenomation by jellyfish is a common occurrence affecting millions of individuals yearly. Little literature exists on jellyfish stings caused by the “moon jellyfish,” Aurelia aurita. The main objective of the present report is to illustrate that A aurita stings are not as benign as once thought and to propose a ...
Original Investigation 
Jonathan I. Silverberg, MD, PhD, MPH; Amy S. Paller, MD, MS
Includes: Supplemental Content

Importance  Atopic dermatitis (eczema) is a chronic inflammatory disorder that is associated with other chronic diseases (eg, asthma), major quality-of-life impairment, sleep disturbance, and the use of potent topical and sometimes systemic corticosteroids, all of which might affect growth in childhood and adolescence. However, previous smaller-scale studies ...

The Cutting Edge 
Savita Yadav, MD; Sunil Dogra, MD, DNB; Dipankar De, MD; Uma Nahar Saikia, MD
Includes: Supplemental Content
Orofacial granulomatosis (OFG), also termed granulomatous cheilitis, oral granulomatosis, and cheilitis granulomatosa, is an uncommon disorder. The presentation can be very varied; pathogenesis is not very clear; and the treatment result is often disappointing. It is characterized by persistent enlargement of the soft tissues of the lip, oral mucosa, and ...
JAMA Dermatology Clinicopathological Challenge 
Guillermo Solano-López, MD; María José Concha-Garzón, MD; Javier Sánchez-Pérez, MD
Research Letter 
Susan A. Oliveria, ScD, MPH; Nandini Selvam, PhD, MPH; Darius Mehregan, MD; Michael A. Marchetti, MD; Hozefa A. Divan, PhD; Bahar Dasgeb, MD; Allan C. Halpern, MD, MS
The increase in incidence and mortality of melanoma over the past 30 years has heightened public and physician awareness. It is suggested that the combination of increasing detection pressure and poor specificity of current diagnostic strategies is driving biopsy rates to alarming levels in younger individuals despite a low risk ...
Daphné Denis, MD; Nathalie Franck, MD; Fanny Fichel, MD; Charlène Levi, MD; Nicolas Dupin, MD
Vemurafenib is a BRAF inhibitor approved by the US Food and Drug Administration as treatment for patients with unresectable or metastatic melanoma harboring the BRAF V600 mutation.1 Recently, vemurafenib-associated renal toxic effects have been reported.2- 4 We describe herein a patient exhibiting Fanconi syndrome as a new renal adverse event ...
Original Investigation 
Girish C. Mohan, MD; Jonathan I. Silverberg, MD, PhD, MPH
Includes: Supplemental Content

Importance  Previous studies found conflicting results as to whether atopic dermatitis (AD) is increased in patients with vitiligo and alopecia areata (AA).

Objective  To compare the prevalence of AD between patients with either vitiligo or AA and those without these disorders by performing a meta-analysis of ...

Case Report/Case Series 
Francesco Lacarrubba, MD; Anna Elisa Verzì, MD; Giuseppe Micali, MD

Importance  Recent studies have reported “comma hairs” as a typical dermoscopic feature of tinea capitis observed at low magnification (×10). The aim of this study was to evaluate the dermoscopic aspects of tinea capitis at high magnification (×150) and its diagnostic role.

Observations  Five children (2 ...

Consensus Statement  FREE
Jeffrey J. Crowley, MD; Jeffrey M. Weinberg, MD; Jashin J. Wu, MD; Andrew D. Robertson, PhD; Abby S. Van Voorhees, MD

Importance  Nail psoriasis can be difficult to treat and has a significant effect on quality of life. Relatively few controlled trials evaluating treatments for nail psoriasis have been published. There is an unmet need for treatment recommendations to guide therapeutic decisions.

Objective  To develop treatment recommendations ...

JAMA Dermatology Clinicopathological Challenge 
Eduardo Rozas-Muñoz, MD; Maria Pilar García-Muret, MD; Lluís Puig, MD
Comment & Response 
Gregory A. Hosler, MD, PhD; Lisa Weibel, MD; Richard C. Wang, MD, PhD
To the Editor Hyperkeratotic spicules may develop as a paraneoplastic syndrome of multiple myeloma. These follicular spicules in multiple myeloma (FSMM) are composed of precipitates of monoclonal dysproteins identical to the serum protein found in these patients.1 Light microscopy of the affected follicular epithelium shows intercellular deposits of eosinophilic material ...
Comment & Response 
Ingrid Lopez-Lerma, MD, PhD; Jordi Mollet, MD; Vicente Garcia-Patos, MD, PhD
To the Editor We read with interest the article by Richey and colleagues1 that described a patient treated with vismodegib who developed multiple erythematous, pruritic perioral papules with white spicules. A diagnosis of trichodysplasia spinulosa (TS) was established exclusively by clinical and histopathologic findings. This diagnosis should be confirmed by ...
Comment & Response 
Sander van Boheemen, PhD; Ron A. M. Fouchier, PhD; Enes Hajdarbegovic, MD
In Reply We are grateful to our colleagues for their contribution in consolidating the available knowledge on follicular spicules in multiple myeloma (FSMM). Gathering evidence on rare disorders is hampered by nonuniform terminology and variations in methodology in addition to the limited number of cases. The great similarity between the ...
Comment & Response 
Justin D. Richey, MD; Terrence Katona, DO; Jeffrey B. Travers, MD, PhD
In Reply We appreciate the letter in response to our case report. We acknowledge the limitations in making a diagnosis of trichodysplasia spinulosa (TS) using only clinical and histologic findings.

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