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 Showing 1-20 of 99 Articles
Viewpoint 
Katherine L. Baquerizo Nole, MD; Joshua D. Fox, BS; Robert S. Kirsner, MD, PhD
Ideally, resource allocation for biomedical research, especially federal funding, should accurately reflect disease burden, the potential for better understanding of biological processes, and the quality of the research. Disability-adjusted life years (DALYs), a health metric that measures years lost due to premature mortality or disability associated with a health condition, ...
Editorial 
Alon Scope, MD; Ralph P. Braun, MD
The 2-step algorithm in dermosopy was initially developed for the diagnosis of melanoma: The first step aims to decide whether the lesion is a melanocytic or nonmelanocytic neoplasm; the clinician seeks the presence of diagnostic criteria for a melanocytic neoplasm (network, aggregated globules or streaks) or for a specific nonmelanocytic ...
Original Investigation 
Lucy L. Chen, MD; Stephen W. Dusza, DrPH; Natalia Jaimes, MD; Ashfaq A. Marghoob, MD
Includes: Supplemental Content

Importance  The 2-step dermoscopy algorithm aims to guide the decision-making process to biopsy or not biopsy a skin lesion by providing the most probable diagnosis via a systematic approach.

Objective  To evaluate the diagnostic accuracy and potential limitations of the first step (to differentiate melanocytic from ...

Editorial: Recognition Process in Dermoscopy; Alon Scope, MD; Ralph P. Braun, MD
JAMA Dermatology Clinicopathological Challenge 
Cesar Lloret-Ruiz, MD; Paula Moles-Poveda, MD; Juan-Jose Terradez-Raro, MD
This case of a painless leg ulcer in an immunosuppressed patient with diverticulitis, a neutropenic fever, and sepsis due to multidrug-resistant Pseudomonas aeruginosa infection showed a cutaneous ulcer with a raised erythematous border and a base with purulent debris. What is your diagnosis?
Research Letter 
Kyle M. Coleman, MD; Johann E. Gudjonsson, MD, PhD; Michael Stecher, MD
MABp1is a true human monoclonal antibody specific for interleukin 1α (IL-1α), a key proinflammatory cytokine involved in sterile inflammation that is abundantly present in psoriatic skin lesions.1 MABp1 differs from previous generations of therapeutic antibodies in that it was cloned from an Epstein-Barr virus–immortalized human B cell that was isolated ...
Research Letter 
Houda Hammami Ghorbel, MD; Fériel Boukari, MD; Eric Fontas, MD, PhD; Henri Montaudié, MD; Philippe Bahadoran, MD, PhD; Jean-Philippe Lacour, MD; Thierry Passeron, MD, PhD
Includes: Supplemental Content
Recent studies have suggested the potential effectiveness of targeting the vascular component of melasma.1- 4 The copper bromide laser (Dual Yellow; Norseld) is a laser with a concomitant-output dual-wavelength light source comprising 90% yellow light at 578 nm, which targets vascular lesions, and 10% green light at 511 nm, which ...
Notable Notes 
Emily C. Milam, BA; Euphemia W. Mu, MD; Seth J. Orlow, MD, PhD
Culinary allusions are abundant in medicine, which boasts a descriptive buffet of visual signs and findings. With over 450 analogies documented in the medical literature,1 those pertaining to food are the most plentiful.2,3
Notable Notes 
Leyre A. Falto-Aizpurua, MD; Brian J. Simmons, BS; Robert D. Griffith, MD; Fleta N. Bray, BS; Keyvan Nouri, MD
José Gay Prieto, born on January 17, 1905, was one of the most renowned Spanish dermatologists. He greatly contributed to the development of dermatology in Spain and around the world.1- 3 He was trained at the San Carlos Clinical Hospital in Madrid, where he excelled academically and stood out for ...
The study by Wataya-Kaneda et al1 in this issue of JAMA Dermatology examines the response of hypopigmented macules in tuberous sclerosis (TS) to topical rapamycin. The authors found that topical rapamycin, 0.2%, gel led to substantial improvement of hypopigmented macules without systemic absorption and that the improvement was more marked ...
The topical calcineurin inhibitors tacrolimus and pimecrolimus are useful and effective anti-inflammatory immunomodulator adjuncts in managing atopic dermatitis (AD). Unfortunately, because of the increased risk of lymphoma in transplant recipients receiving systemic tacrolimus and because of malignant neoplasms in animal studies with pimecrolimus, their use as topical agents has raised ...
Original Investigation 
Mari Wataya-Kaneda, MD, PhD; Mari Tanaka, MD, PhD; Lingli Yang, MD, PhD; Fei Yang, BS; Daisuke Tsuruta, MD, PhD; Ayumi Nakamura, BPharm; Shoji Matsumoto, PhD; Toshimitsu Hamasaki, PhD; Atushi Tanemura, MD, PhD; Ichiro Katayama, MD, PhD
Includes: Supplemental Content

Importance  Tuberous sclerosis complex (TSC) is an autosomal dominant disorder leading to the aberrant activation of the mammalian target of rapamycin complex 1. Although the efficacy of mammalian target of rapamycin complex 1 inhibitors against tumors in patients with TSC, including facial angiofibroma, has been well investigated, ...

Editorial: Rapamycin, Tuberous Sclerosis, Hypopigmented Macules; Jack L. Arbiser, MD, PhD
Original Investigation  FREE
David J. Margolis, MD, PhD; Katrina Abuabara, MD, MA; Ole J. Hoffstad, MS; Joy Wan, MD; Denise Raimondo, MSEd; Warren B. Bilker, PhD

Importance  A black box warning describes a potential risk of malignancy associated with topical use of pimecrolimus to treat atopic dermatitis due to its similarity to oral calcineurin inhibitors used in solid-organ transplantation and spontaneous reporting of malignancies, including lymphomas and cutaneous malignancies.

Objective  To evaluate ...

Case Report/Case Series 
Jonathan L. Levinsohn, BA; Jennifer M. McNiff, MD; Richard J. Antaya, MD; Keith A. Choate, MD, PhD
Includes: Supplemental Content

Importance  Recent data demonstrated somatic mutations in GJB2 that were present in affected porokeratotic eccrine ostial and dermal duct nevus (PEODDN) tissue but absent in unaffected skin. Recognizing that PEODDN lesions can also appear in individuals with keratitis-ichthyosis-deafness syndrome and finding somatic mutations in their cohort, the ...

JAMA Dermatology Clinicopathological Challenge 
Paula Molés-Poveda, MD; Lucero Noguera, MD; Antonio Torrelo, MD
Research Letter 
Sean Chen, BA; Peter Mattei, MD; Jing You, BS; Nara L. Sobreira, MD, PhD; Ginette A. Hinds, MD
Hidradenitis suppurativa (HS) (acne inversa; OMIM 142690) is a chronic skin condition associated with the formation of painful, suppurative, and scarring nodules that primarily affect the axillary, inguinal, and perineal areas. Heterozygous mutations in the γ-secretase genes have been identified in the pathogenesis of autosomal dominant forms of HS in ...
Notable Notes 
Fleta N. Bray, BS; Brian J. Simmons, BS; Leyre Ainara Falto-Aizpurua, MD; Robert Denison Griffith, MD; Keyvan Nouri, MD
In 19th-century Europe, leading minds of cutaneous disease flocked to the world’s great hubs of medical learning—London, Paris, and Vienna—to celebrate the rise of dermatological moulage. Here, hapless victims of dermatoses were extracted from the clinics of famed European physicians for plaster casting. Moulers poured hot wax into the plaster ...
Original Investigation 
Tianhui Chen, MD, PhD; Mahdi Fallah, MD, PhD; Asta Försti, PhD; Elham Kharazmi, MD, PhD; Kristina Sundquist, MD, PhD; Kari Hemminki, MD, PhD
Includes: Supplemental Content

Importance  The risk of next melanoma in patients with 2 or more previous melanomas stratified by familial and sporadic cases separately has not yet been reported, although a few population-based studies have assessed the risk of second melanoma.

Objective  To assess the risk of next melanoma ...

Original Investigation 
Emilie Bequignon, MD; Tu Anh Duong, MD; Emilie Sbidian, MD, PhD; Laurence Valeyrie-Allanore, MD; Saskia Ingen-Housz-Oro, MD; Veronique Chatelin, MD; André Coste, MD, PhD; Pierre Wolkenstein, MD, PhD; Olivier Chosidow, MD, PhD; Jean François Papon, MD, PhD

Importance  Ear, nose, and throat (ENT) lesions are frequently involved in Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN), although a detailed description is lacking in the literature.

Objectives  To describe ENT lesions at the acute stage and follow-up in a large series of patients with SJS/TEN ...

Case Report/Case Series 
Daniel A. Grabell, MBA; Loderick A. Matthews, MS; Kim B. Yancey, MD; Benjamin F. Chong, MD, MSCS

Importance  Anti–type VII collagen autoantibodies are often detectable in patients with bullous systemic lupus erythematosus (BSLE). However, the timing of their appearance preceding the onset of disease is unknown to date.

Observations  We report the case of a 50-year-old woman with a history of SLE who ...

JAMA Dermatology Clinicopathological Challenge 
Roman Bronfenbrener, MD; Jason Cohen, MD; Jordan B. Slutsky, MD

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