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 Showing 1-20 of 92 Articles
Original Investigation 
Rena C. Zuo, BA; Andrea B. Apolo, MD; John J. DiGiovanna, MD; Howard L. Parnes, MD; Corrine M. Keen, RN, MS; Swati Nanda, BS; William L. Dahut, MD; Edward W. Cowen, MD, MHSc

Importance  Cabozantinib S-malate is a vascular endothelial growth factor receptor 2, c-MET, and RET multitargeted tyrosine kinase inhibitor that has antiangiogenic and antitumorigenic properties with potential efficacy for the treatment of several cancers. Cutaneous reactions, one of the most frequently observed adverse effects associated with tyrosine kinase ...

Case Report/Case Series 
Urvi Patel, MD; Lynn Cornelius, MD; Milan J. Anadkat, MD

Importance  MEK inhibitors are being evaluated in clinical trials for treatment of different malignant neoplasms; trametinib dimethyl sulfoxide was approved by the US Food and Drug Administration for melanoma in 2013. We present 3 cases of patients receiving MEK inhibitors who developed an atypical eruption.

Observations  ...

JAMA Dermatology Clinicopathological Challenge 
Juan Francisco Mir-Bonafe, MD; Eulalia Baselga Torres, MD, PhD; Rogelio Gonzalez Sarmiento, MD, PhD
Alexander A. Navarini, MD, PhD; Michael A. Simpson, PhD; Luca Borradori, MD; Nikhil Yawalkar, MD; Christoph Schlapbach, MD, PhD
Acute generalized exanthematous pustulosis (AGEP) and generalized pustular psoriasis (GPP) show multiple overlapping clinical features. Recently, mutations in the IL36RN gene encoding the interleukin (IL)-36 receptor antagonist (IL-36Ra) have been found to cause increased secretion of inflammatory cytokines in GPP and in a subset of AGEP.1,2 In both conditions, half ...
Original Investigation  FREE
Jeremy A. Brauer, MD; Viktoryia Kazlouskaya, MD, PhD; Hamad Alabdulrazzaq, MBBCh; Yoon Soo Bae, MD; Leonard J. Bernstein, MD; Robert Anolik, MD; Patricia A. Heller, MD; Roy G. Geronemus, MD
Includes: Supplemental Content

Importance  Fractional laser technology is routinely used in the treatment of acne scarring, with thermal injury resulting in collagen synthesis and remodeling. Use of a picosecond pulse duration with a diffractive lens array may be a new technologic advancement in the treatment of acne scarring.

Objective  ...

Case Report/Case Series 
Noriaki Nakai, MD, PhD; Kazumitsu Sugiura, MD, PhD; Masashi Akiyama, MD, PhD; Norito Katoh, MD, PhD

Importance  Acute generalized exanthematous pustulosis (AGEP) is a rare and severe type of drug eruption. Dihydrocodeine phosphate is a semisynthetic opioid analgesic. Recently, recessive mutations in IL36RN have been identified in generalized pustular psoriasis (GPP). To date, 4 cases of AGEP and IL36RN mutation without previous history ...

Consensus Statement 
Caroline C. Kim, MD; Susan M. Swetter, MD; Clara Curiel-Lewandrowski, MD; James M. Grichnik, MD, PhD; Douglas Grossman, MD, PhD; Allan C. Halpern, MD; John M. Kirkwood, MD; Sancy A. Leachman, MD, PhD; Ashfaq A. Marghoob, MD; Michael E. Ming, MD, MSCE; Kelly C. Nelson, MD; Emir Veledar, PhD; Suraj S. Venna, MD; Suephy C. Chen, MD, MS

Importance  The management of clinically atypical nevi/dysplastic nevi (CAN/DN) is controversial, with few data to guide the process. Management recommendations for DN with positive histologic margins were developed by the Delphi method to achieve consensus among members of the Pigmented Lesion Subcommittee (PLS) of the Melanoma Prevention ...

The Cutting Edge 
Sabrina Kindem, MD; Carlos Serra-Guillén, MD; Guillermo Sorní, MD; Carlos Guillén, MD; Onofre Sanmartín, MD
JAMA Dermatology Clinicopathological Challenge 
Oluwatobi A. Ogbechie, BA; A. Brooke Eastham, MD; Ruth Ann Vleugels, MD, MPH
Ellen N. Pritchett, MD, MPH; Jeanyoung Kim, MD; Khyati Patel, MD; Tejesh Patel, MD; Carrie Ann Cusack, MD
Birt-Hogg-Dubé syndrome (BHDS), an autosomal dominant condition caused by mutations in the FLCN gene, is characterized by fibrofolliculomas, spontaneous pneumothorax, and renal cell carcinoma. Herein, we report the first case to our knowledge of BHDS in an African patient.
Ramone F. Williams, MPhil, MSIV; Gideon P. Smith, MD, PhD
This Viewpoint examines Google Trends data to show how search engine query data can reveal temporal variations in public interest that can be used to optimize public health initiatives in dermatology.
In this issue Moye and colleagues1 examine psychological distress in patients with atypical mole syndrome attending a pigmented lesion clinic (PLC) who are receiving biannual total body skin examination using total body digital photography (TBDP). The authors propose that TBDP, which involves high-resolution digital photography with professional lighting and standardized ...
Original Investigation 
Caroline G. Watts, MPH; Anne E. Cust, MPH (Hons), PhD; Scott W. Menzies, MBBS, PhD; Elliot Coates, BSc (Hons), MBBS; Graham J. Mann, MBBS, PhD; Rachael L. Morton, MScMed (ClinEpi) (Hons), PhD
Includes: Supplemental Content

Importance  Regular surveillance of individuals at high risk for cutaneous melanoma improves early detection and reduces unnecessary excisions; however, a cost analysis of this specialized service has not been undertaken.

Objective  To determine the mean cost per patient of surveillance in a high-risk clinic from the ...

Original Investigation 
Molly S. Moye, MD; Sallyann M. C. King, MD, MSc; Zakiya P. Rice, MD; Laura K. DeLong, MD, MPH; Anne M. Seidler, MD, MBA; Emir Veledar, PhD; Clara Curiel-Lewandrowski, MD; Suephy C. Chen, MD, MS
Includes: Supplemental Content

Importance  Cancer worry about developing melanoma in at-risk patients may affect one’s quality of life and adherence to screening. Little is known about melanoma-related worry in patients with atypical mole syndrome (AMS).

Objectives  To quantify levels and elucidate predictors of worry related to developing melanoma in ...

Case Report/Case Series 
Robert M. Gathings, MD; Raveena Reddy, MD; Daniel Santa Cruz, MD; Robert T. Brodell, MD

Importance  A new condition, gadolinium-associated plaques (GAP), is reported in 2 patients. It is related to a particular type of gadolinium (gadodiamide) used for contrast-enhanced radiologic studies.

Observations  Erythematous plaques, 0.5 to 2.5 cm in diameter, were pruritic in one case and asymptomatic in a second ...

Research Letter 
Stephanie Wang, BS; Lynda Shadrake, BS; Milena J. Lyon, MD; Hajwa Kim, MS, MA; Rachel Yudkowsky, MD, MHPE; Claudia Hernandez, MD
Effective physician-patient communication is essential for the delivery of quality dermatologic care. The Accreditation Council for Graduate Medical Education recognizes the importance of physician communication and interpersonal skills (CIS) as proficiency in these skills is identified as a core competency in the Program Requirements for Graduate Medical Education in Dermatology.1 ...
JAMA Dermatology Clinicopathological Challenge 
Corey M. DeWitt, BA; Jose E. Peraza, MD; Daniel M. Peraza, MD
Hong Liang Tey, MRCP; Evelyn Yuxin Tay, MRCP; Taige Cao, MBBS
Miliaria profunda (MP) is a condition of sweat duct obstruction manifesting with generalized papular eruption and anhidrosis.1,2 Using imaging with high-definition optical coherence tomography (HD-OCT), we identified, in vivo, the depth of lesions in MP and the likely location of sweat duct obstruction. To our knowledge, this is the first ...
Ian A. Maher, MD; Scott Fosko, MD; Murad Alam, MD
In this issue of JAMA Dermatology, Joo and colleagues1 report the results of a randomized clinical trial (RCT) comparing purse-string suture closure to secondary intention healing for wounds on the trunk and extremities. By rigorously examining a commonly used dermatologic procedure, their work has the potential to immediately impact the ...
Original Investigation 
Omer Ibrahim, MD; Misbah Khan, MD; Diana Bolotin, MD, PhD; Meghan Dubina, MD; Michael Nodzenski, BA; Wareeporn Disphanurat, MD; Rohit Kakar, MD; Simon Yoo, MD; Dennis Whiting, PA-C; Dennis P. West, PhD; Emily Poon, PhD; Emir Veledar, PhD; Murad Alam, MD, MSCI

Importance  Keratosis pilaris (KP) is a common skin disorder of follicular prominence and erythema that typically affects the proximal extremities, can be disfiguring, and is often resistant to treatment. Shorter-wavelength vascular lasers have been used to reduce the associated erythema but not the textural irregularity.

Objective  ...

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