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 Showing 1-20 of 86 Articles
Original Investigation 
Martina Sanlorenzo, MD; Igor Vujic, MD; Adil Daud, MD; Alain Algazi, MD; Matthew Gubens, MD; Sara Alcántara Luna, MD; Kevin Lin, BS; Pietro Quaglino, MD; Klemens Rappersberger, MD; Susana Ortiz-Urda, MD, PhD, MBA

Importance  Immunomodulatory anticancer drugs, such as the anti–programmed death-1 drug pembrolizumab, have shown promising results in trials, and more patients will receive such treatments. Little is known about cutaneous adverse events (AEs) caused by these drugs and their possible correlation with treatment response.

Objective  To describe ...

Original Investigation  FREE
Alexander Egeberg, MD; Usman Khalid, MD; Gunnar Hilmar Gislason, MD, PhD; Lotus Mallbris, MD, PhD; Lone Skov, MD, PhD, DMSc; Peter Riis Hansen, MD, PhD, DMSc
Includes: Supplemental Content

Importance  Psoriasis, psoriatic arthritis, and uveitis are inflammatory disorders with significant overlap in their inflammatory pathways. Limited evidence is available about the relationship between psoriatic disease and uveitis.

Objective  To investigate the potential bidirectional relationship between psoriatic disease, including psoriasis and psoriatic arthritis, and uveitis.

Design, ...

JAMA Dermatology Clinicopathological Challenge 
Jennifer C. Aronica, MD, MS; Arash Radfar, MD, PhD; Ali A. Damavandy, MD

This case report of a woman with unilateral stellate purpura of the ankle reveals how a complete skin examination is critical for diagnostic and prognostic purposes.

Original Investigation  FREE
Giuliana Carlos, MBBS; Rachael Anforth, BMed; Arthur Clements, BSc (Med), MBBS; Alexander M. Menzies, MBBS; Matteo S. Carlino, MBBS; Shaun Chou, MBBS; Pablo Fernandez-Peñas, MD, PhD

Importance  The cutaneous adverse effects of the BRAF inhibitors vemurafenib and dabrafenib mesylate in the treatment of metastatic melanoma have been well reported. The addition of a MEK inhibitor to a BRAF inhibitor improves the blockade of the mitogen-activated protein kinase pathway. The combination of dabrafenib with ...

Research Letter 
Mina S. Ally, MD; Jean Y. Tang, MD, PhD; Joselyn Lindgren, MS; Maria Acosta-Raphael, BA; Melika Rezaee, BA; Anita M. Chanana, BS; Ervin H. Epstein Jr, MD

This study of vismodegib-treated patients reports the therapeutic benefit of amlodipine for vismodegib-related muscle cramps.

Observation 
Xu Hua Tang, MD, PhD; Hui Zhou, MD, PhD; Xing Qi Zhang, MD, PhD; Jian De Han, MD; Qian Gao, MD

This case report demonstrates that Emmonsia pasteuriana fungal infection, though uncommon, can affect immunocompromised patients.

Original Investigation 
Danielle E. Levine, MD; Pritesh S. Karia, MPH; Chrysalyne D. Schmults, MD, MSCE

Importance  Patients with multiple cutaneous squamous cell carcinomas (CSCCs) pose a management challenge for physicians, but their prognosis is unknown because outcomes have not been compared between patients who form single vs multiple CSCCs.

Objective  To compare outcomes in patients with 1 vs multiple CSCCs.

Design, ...

JAMA Dermatology Clinical Evidence Synopsis  FREE
Victoria R. Sharon, MD, DTMH; April W. Armstrong, MD, MPH

Clinical Question  Dermatologists diagnose and treat sexually transmitted infections with varying frequency, and have an opportunity to monitor at-risk individuals for chlamydia and gonorrhea. What are the recommended screening guidelines for chlamydia and gonorrhea in men and women in the United States?

Bottom Line  While the ...

Comment & Response 
Bruce G. Haffty, MD; David C. Beyer, MD; Brian D. Kavanagh, MD, MPH

To the Editor As Fellows in the American Society for Radiation Oncology (ASTRO), the world’s leading radiation oncology society, we commend the caution and concern raised by Linos et al1 in “A Sudden and Concerning Increase in the Use of Electronic Brachytherapy for Skin Cancer.”1 The ...

Comment & Response 
Eleni Linos, MD, DrPH; Marta VanBeek, MD, MPH; Jack S. Resneck Jr, MD

In Reply We thank our colleagues at the American Society for Therapeutic Radiology and Oncology (ASTRO) for their letter supporting our Viewpoint on the sudden and concerning rise in use of electronic brachytherapy (EBT).1 Both the American Academy of Dermatology (AAD) position statement2 and ASTRO’s letter ...

Case Report/Case Series  FREE
Pedram Gerami, MD; Oriol Yélamos, MD; Christina Y. Lee, BA; Roxana Obregon, BA; Pedram Yazdan, MD; Lauren M. Sholl, MS; Gerta E. Guitart; Ching-Ni Njauw, MS; Hensin Tsao, MD, PhD

Importance  Several kindreds having germline BAP1 mutations with a propensity for uveal and cutaneous melanomas and other internal malignancies have been described in an autosomal dominant tumor predisposition syndrome. However, clinically atypical moles have not been previously recognized as a component of this syndrome, to our knowledge. ...

Research Letter 
Iris Martin, BA; Porntawee Paul Aphivantrakul, BS; Kuang-Ho Chen, PhD; Suephy C. Chen, MD, MS

This review of teledermatology referral adherence reports that primary health care professionals followed 80% of recommendations and that physicians who attended a dermatology training course were no more likely to follow recommendations.

Observation 
Jordan Leung, BSc; Paul Kuzel, MD; Anil Kurian, MD; Alain Brassard, MD, FRCPC

This case report describes effective treatment of dominant dystrophic epidermolysis bullosa with minocycline.

Case Report/Case Series 
Tania M.  Gonzalez Santiago, MD; Andrey Zavialov, PhD; Janna Saarela, MD, PhD; Mikko Seppanen, MD, PhD; Ann M. Reed, MD; Roshini S. Abraham, PhD; Lawrence E. Gibson, MD

Importance  Mutations in the CERC1 gene associated with deficiency in the ADA2 protein (DADA2) have been implicated in the pathogenesis of cutaneous polyarteritis nodosa (cPAN) and early-onset vasculopathy. DADA2 is not only limited to cPAN and vasculopathy but also includes immunodeficiency that affects several cellular compartments, including ...

Research Letter  FREE
Gery P. Guy Jr, PhD, MPH; Zahava Berkowitz, MSc, MSPH; Dawn M. Holman, MPH; Anne M. Hartman, MS, MA

This analysis of data from the National Health Interview Survey reports significant reductions in indoor tanning among US adults from 2010 to 2013.

Observation 
Olushola Akinshemoyin Vaughn, BA; Molly A. Hinshaw, MD; Joyce M. Teng, MD, PhD

This case report describes a possible solution to the challenge of clinically distinguishing acantholytic dyskeratotic epidermal nevus, often a congenital condition, from Darier disease, which is acquired.

Case Report/Case Series 
Brittany G. Craiglow, MD; Brett A. King, MD, PhD

Importance  Vitiligo is a common condition that is often emotionally devastating for patients. At present, no reliably effective treatments are available.

Observations  Recent advances in the understanding of the pathogenesis of vitiligo suggest that Janus kinase inhibitors may be a therapeutic option. We report a case ...

Research Letter 
Joel Hillhouse, PhD; Jerod L. Stapleton, PhD; L. Carter Florence, MPH; Sherry Pagoto, PhD

This survey found that many young women use indoor tanning facilities that are not tanning-only salons and engage in risky tanning behavior.

Research Letter 
Pauline Laly, MD; Saskia Ingen-Housz-Oro, MD; Marie Beylot-Barry, MD, PhD; Laurence Verneuil, MD, PhD; Henri Adamski, MD; Pauline Brice, MD; Martine Bagot, MD, PhD

This retrospective study of patients with cutaneous anaplastic large cell lymphoma reports the efficacy of vinblastine as monotherapy for this condition.

Observation 
Chiaki Murase, MD; Michihiro Kono, MD, PhD; Kazue Nakanaga, PhD; Norihisa Ishii, MD, PhD; Masashi Akiyama, MD, PhD

This case report details successful use of negative-pressure wound therapy for treatment of an advanced Buruli ulcer and suggests that such treatment might be effective in similar future cases.

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