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 Showing 1-20 of 79 Articles
Case Report/Case Series 
Vijay Zawar, MD, DNB, DVD, FAAD; Pravin Bharatia, MD; Antonio Chuh, MD, FRCP, FRCPCH
Includes: Supplemental Content

Importance  Recognition of different clinical presentations of viral and virally triggered (“paraviral”) exanthems is necessary for patients to be appropriately diagnosed and counseled.

Observations  Nine children presented with eruptions of hypopigmented macules following coryzal symptoms. Other diagnostic considerations, such as pityriasis alba, pityriasis versicolor, and progressive ...

Vanessa L. Pascoe, BA; Alexandra B. Kimball, MD, MPH
Hidradenitis suppurativa (HS) is a chronic, destructive, debilitating inflammatory skin disease characterized by recurrent, painful, deep-seated nodules and/or abscesses in intertriginous areas.1 It is also relatively common, with a reported prevalence as high as 1% to 4%.2,3 Nevertheless, HS has historically been an orphan disease, unclaimed by any specialty, owing, ...
Recent postmarketing studies and the US Food and Drug Administration have found that finasteride, 1 mg, for androgenic alopecia has been associated with persistent sexual and nonsexual adverse effects.1 The mechanisms of these symptoms in humans are unknown. Finasteride, 1 mg, has been associated with male infertility, and 5% of ...
Comment & Response 
Baotao Huang, MD; Ran Zhang, MBBS; Mao Chen, MD, PhD
To the Editor We greatly appreciated the article by Wu et al,1 which showed the independent association between long-term hypertension, long-term administration of β-blockers, and incident psoriasis in a large prospective cohort. However, although the study presented new evidence of the association, no management advice was proposed. How should patients ...
Original Investigation 
Iben Marie Miller, MD; Christina Ellervik, MD, PhD; Gabrielle Randskov Vinding, MD; Kian Zarchi, MD; Kristina Sophie Ibler, MD; Kim Mark Knudsen, PhD; Gregor B. E. Jemec, DMSc, MD
Includes: Supplemental Content

Importance  An association between the metabolic syndrome (MetS) and chronic inflammatory diseases, such as psoriasis or rheumatoid arthritis, has been suggested. Hidradenitis suppurativa (HS), a more localized chronic inflammation of the skin, has been speculated to have a similar association. Hidradenitis suppurativa is a substantial burden for ...

Original Investigation 
Henry W. Lim, MD; Pearl E. Grimes, MD; Oma Agbai, MD; Iltefat Hamzavi, MD; Marsha Henderson, MD; Madelaine Haddican, MD; Rita V. Linkner, MD; Mark Lebwohl, MD

Importance  Narrowband UV-B (NB–UV-B) phototherapy is used extensively to treat vitiligo. Afamelanotide, an analogue of α–melanocyte-stimulating hormone, is known to induce tanning of the skin.

Objective  To evaluate the efficacy and safety of combination therapy for generalized vitiligo consisting of afamelanotide implant and NB–UV-B phototherapy.

Design, ...

Lola V. Stamm, PhD
The discovery in July 2014 of 6 heat-sealed glass vials of the smallpox virus along with more than 300 vials of other viral and bacterial pathogens in a cold storage room at the National Institutes of Health campus (Bethesda, Maryland) has received only modest attention.1 Perhaps this is because most ...
Topics: smallpox
Case Report/Case Series  FREE
Iris Spoerri, PhD; Michela Brena, MD; Julie De Mesmaeker, PhD; Nina Schlipf, PhD; Judith Fischer, MD, PhD; Gianluca Tadini, MD; Peter H. Itin, MD; Bettina Burger, PhD
Includes: Supplemental Content

Importance  Ichthyosis with confetti (IWC) is a genodermatosis caused by dominant negative mutations in the gene encoding keratin 10 (KRT10). We investigated clinical and genetic details of a substantial number of patients with IWC in order to define major and minor criteria for diagnosis of ...

Editorial  FREE
Keith A. Choate, MD, PhD; Leonard M. Milstone, MD
Cases of a distinct congenital ichthyosiform erythroderma with evolving white spots were first reported in 1984 and have been assigned a variety of names including ichthyosis en confetti, ichthyosis variegata, congenital reticular ichthyosiform erythroderma (CRIE), and MAUIE syndrome (micropinnae, alopecia universalis, congenital ichthyosis, and ectropion). The first report of this ...
Invited Commentary 
Alan B. Fleischer Jr, MD
Every schoolchild in the United States learns the line from the Declaration of Independence that “all men are created equal.” The aforementioned statement addresses certain inalienable rights. Yet, from a medical standpoint, are we all the same, do we manifest disease the same way, and do we respond to treatments ...
Topics: minority groups
Research Letter 
Tanya Bhattacharya, MD; Jonathan I. Silverberg, MD, PhD, MPH
Includes: Supplemental Content
Most evidence supporting systemic therapy for atopic dermatitis (AD) is derived from randomized clinical trials (RCTs) performed outside the United States, particularly in Europe. However, the US population vastly differs from that of Europe and other regions, with greater racial and ethnic diversity and heterogeneity. This is not a trivial ...
Nahid Y. Vidal, MD; Ronda S. Farah, MD; Karolyn A. Wanat, MD
“Saxophone penis” refers to swelling and deformity of the penile shaft secondary to multiple causes, and we report a novel case of imiquimod-induced acute-onset saxophone penis.
Topics: penis; imiquimod
JAMA Dermatology Clinicopathological Challenge 
Jake E. Turrentine, MD; Olayemi Sokumbi, MD; Nnenna G. Agim, MD
Original Investigation 
Shadi Rashtak, MD; Shahryar Khaleghi, PharmD; Mark R. Pittelkow, MD; Joseph J. Larson, BS; Brian D. Lahr, MS; Joseph A. Murray, MD

Importance  Isotretinoin is the standard treatment for refractory severe nodulocystic acne. A true association between prior isotretinoin use and development of inflammatory bowel disease (IBD) is uncertain. Addressing the reality of this association is important in decision making for both the clinician and the patient when isotretinoin ...

Original Investigation 
Rena C. Zuo, BA; Haley B. Naik, MD; Seth M. Steinberg, PhD; Kristin Baird, MD; Sandra A. Mitchell, CRNP, PhD; Zoya Kuzmina, MD; Steven Z. Pavletic, MD, MS; Edward W. Cowen, MD, MHSc

Importance  Cutaneous manifestations of chronic graft-vs-host disease (GvHD) are highly variable and may recapitulate well-characterized autoimmune diseases, including systemic sclerosis and Sjögren syndrome. However, vitiligo and alopecia areata (AA) have not been well characterized in the chronic GvHD setting.

Objective  To determine laboratory markers, transplant-related factors, ...

Case Report/Case Series 
Christine Guo Lian, MD; Lynette M. Sholl, MD; Labib R. Zakka, MA, MD; Teresa M. O, MD; Cynthia Liu; Shuyun Xu, MD, PhD; Ewelina Stanek; Elizabeth Garcia, PhD; Yonghui Jia, PhD; Laura E. MacConaill, PhD; George F. Murphy, MD; Milton Waner, MD; Martin C. Mihm Jr, MD
Includes: Supplemental Content

Importance  Port-wine stains (PWSs) are common congenital cutaneous capillary malformations. A somatic GNAQ mutation was recently identified in patients with sporadic PWSs and Sturge-Weber syndrome. However, subsequent studies to confirm or extend this observation are lacking.

Observations  We report a long-standing, unilateral facial PWS of a ...

Case Report/Case Series 
Sander van Boheemen, MSc; Terry Jones, PhD; Barbara Muhlemann, BSc; Mariet C. Feltkamp, PhD; Ron A. M. Fouchier, PhD; Enes Hajdarbegovic, MD

Importance  The cause of follicular spicules in multiple myeloma (MM) is not known.

Observations  We present a case of follicular spicules in a patient with MM, which is very reminiscent of trichodysplasia spinulosa caused by a polyomavirus. No trichodysplasia spinulosa–associated polyomavirus could be isolated from the ...

Editor's Note 
June K. Robinson, MD; Jeffrey P. Callen, MD
In December 1999, Michael Bigby, MD, introduced the Evidence-Based Dermatology Section of this journal. The purpose was to alert clinicians to important advances in dermatology by selecting articles with results most likely to be true and useful to the busy physician when making decisions about patient care. For 15 years, ...
Research Letter 
Arash Taheri, MD; Parisa Mansoori, MD; Hossein Alinia, MD; Robin Lewallen, MD; Steven R. Feldman, MD, PhD
Ingrown toenails can be due to trauma, improper nail cutting, and/or anatomic abnormalities of the nail apparatus. In the setting of normal anatomy, they are usually treated conservatively, but the presence of a sharp edge of the nail in the ulcer may prevent wound healing. Isolation of the nail plate ...
Comment & Response 
Brian Poligone, MD, PhD
To the Editor I read with interest the article by Hurley et al1 that sets out to describe the relationship between free drug samples and dermatologists’ prescribing patterns. The authors duly note their study limitations, including its restriction to a single academic medical center, its representation of the nonacademic pool ...

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