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 Showing 1-20 of 80 Articles
Case Report/Case Series 
Frank W. Chen, MD; Diane Tseng, MD, PhD; Sunil Reddy, MD; Adil I. Daud, MD; Susan M. Swetter, MD

Importance  Eruptive melanocytic nevi (EMN) are characterized by the sudden onset of numerous melanocytic nevi and have been traditionally described in the setting of immunosuppression. Selective BRAF inhibitors, such as vemurafenib cause multiple cutaneous adverse effects, including the formation of cutaneous squamous cell carcinoma, as well as ...

Editorial 
Samuel J. Balin, MD, PhD; Raymond L. Barnhill, MD, MSc
Reason dictates that rapidly growing melanomas carry a worse prognosis than those that are quiescent. Indeed, much focus has been given to calculating the growth index of melanomas as defined by their mitotic rate1,2—a process that requires counting the number of mitoses in several high-power fields. As expected, mitotic rate ...
Topics: melanoma
We have all experienced the patient with red legs, referred for refractory “cellulitis” not responding to systemic antibiotics. Primary care, urgent care, hospitalist, and emergency department physicians are on the front line seeing these patients; however, they often lack the training that allows them to recognize cellulitis mimickers. This constitutes ...
JAMA Dermatology Clinicopathological Challenge 
Katherine M. Hunt, BS; Rebecca Kissel, MD; Lucia Seminario-Vidal, MD, PhD
Original Investigation  FREE
Sarah Shen, MBBS, BMedSci; Rory Wolfe, BSc, PhD; Catriona A. McLean, FRCPA, MD; Martin Haskett, FACD; John W. Kelly, FACD, MD
Includes: Supplemental Content

Importance  Mitotic rate is now recognized as having independent prognostic significance in melanoma survival. However, its clinicopathologic associations have not been the focus of any previous study.

Objective  To identify a set of patient and tumor characteristics associated with high-mitotic-rate melanoma with the aim of facilitating ...

Original Investigation 
Ryan Y. Arakaki, MD; Lauren Strazzula, BA; Elaine Woo, MD; Daniela Kroshinsky, MD, MPH

Importance  Cellulitis is a common and costly problem, often diagnosed in the outpatient setting. Many cutaneous conditions may clinically mimic cellulitis, but little research has been done to assess the magnitude of the problem.

Objective  To determine if obtaining dermatology consultations in the outpatient primary care ...

Case Report/Case Series 
John T. O’Malley, MD, PhD; Vivette D. D’Agati, MD; William H. Sherman, MD; Marc E. Grossman, MD
Includes: Supplemental Content

Importance  Acquired cutis laxa is a rare cutaneous manifestation of hematologic malignancy. We report a case of γ heavy chain deposition disease (HCDD) associated with acquired cutis laxa, renal involvement, and hypocomplementemia and propose a mechanism of elastic fiber degradation in the skin of this patient with ...

Case Report/Case Series 
Christoph T. Ellebrecht, MD; Eun J. Choi, BS; David M. Allman, PhD; Donald E. Tsai, MD, PhD; William A. Wegener, MD, PhD; David M. Goldenberg, ScD, MD; Aimee S. Payne, MD, PhD
Includes: Supplemental Content

Importance  B-cell depletion with the anti-CD20 antibody rituximab is highly effective for pemphigus vulgaris (PV) treatment. However, most patients experience relapse, and intravenous rituximab infusions are expensive. Therefore, cost-effective anti-CD20 therapies are desirable.

Observations  A compassionate-use investigational new drug protocol was approved to administer veltuzumab, a ...

Observation 
Davide Altamura, MD; Francesco Simonacci, MD; Torkan Hirbod, MD; Evdokia Arkoumani, MD; Roberto Verdolini, MD, FRCP
Imiquimod is a topical immune response modifier with potent antiviral and antitumor effects. It induces an immune-mediated response, demonstrated by changes in the lymphocytic infiltrate and locally produced cytokines.1,2
JAMA Dermatology Clinicopathological Challenge 
Alicia J. Little, PhD; Antonio Subtil, MD, MBA; Jaehyuk Choi, MD, PhD
Viewpoint 
Joseph C. Pierson, MD
Shortly after I began prescribing certain topical medications in the early 1990s, I started to question the ritual. That universal thrill new clinicians experience when confidently knowing the diagnosis and its treatment was soon tempered by the realization that many patients had arrived already knowing both, and they resented a ...
Editorial 
H. Ray Jalian, MD; Mathew M. Avram, MD, JD
Since the passing of the Congressional Balanced Budget Act in 1997,1 the scope of practice of mid-level health care providers, namely nurse practitioners and physician assistants (hereinafter “mid-level providers”), has rapidly expanded. While originally envisioned to improve access to primary care in underserved areas under the supervision of a physician, ...
Topics: dermatology
Original Investigation  FREE
Brett Coldiron, MD; Mondhipa Ratnarathorn, MD

Importance  Mid-level providers (nurse practitioners and physician assistants) were originally envisioned to provide primary care services in underserved areas. This study details the current scope of independent procedural billing to Medicare of difficult, invasive, and surgical procedures by medical mid-level providers.

Objective  To understand the scope ...

The Cutting Edge 
Nicholas A. Richmond, MD; Sonia A. Lamel, MD; Liza R. Braun, MD; Alejandra C. Vivas, MD; Thomas Serena, MD; Robert S. Kirsner, MD, PhD
Includes: Supplemental Content
Observation 
Viswanath R. Belum, MD; Amanda Hill, RN; Evan Matros, MD; Mario E. Lacouture, MD; Christopher A. Barker, MD
In this case, radiation dermatitis (RD) is characterized by a differential response in 2 developmentally equivalent tissues from distinct anatomic locations.
Observation 
Gang Wang, MD, PhD; Jeremy S. Bordeaux, MD, MPH; David J. Rowe, MD; Kord S. Honda, MD
Includes: Supplemental Content
Lymphoepithelioma-like carcinoma of the skin (LELCS) is a very rare primary skin neoplasm that most frequently occurs on the sun-exposed skin of the head and neck in elderly individuals.1 The histogenesis of LELCS remains controversial between an adnexal origin vs an inflamed squamous cell carcinoma (SCC).2,3 It has a small ...
JAMA Dermatology Clinicopathological Challenge 
Virginia N. Haselden, BA; Janine C. Malone, MD; Courtney R. Schadt, MD
Original Investigation 
Fan Xiang, PhD; Robyn Lucas, PhD; Simon Hales, PhD; Rachel Neale, PhD
Includes: Supplemental Content

Importance  Nonmelanoma skin cancers (NMSCs) are the most common cancers in fair-skinned populations. Their incidence continues to increase in many countries. Exposure to UV radiation (UVR) is the primary cause of NMSC, although the pattern of exposure that gives rise to different types of NMSC appears to ...

Original Investigation  FREE
Pankaj Kumar, MSc; Lalit Dar, MD; Shashi Saldiwal, MA; Sangeeta Varma, MD; Aashish datt Upadhyay, MA; Deepti Talwar, BTec; Vinod Kumar Sharma, MD; Kaushal Kumar Verma, MD; Sada Nand Dwivedi, PhD; Rama Raj, MPhil; Somesh Gupta, MD

Importance  Intralesional antigen therapy has been used in the treatment of anogenital warts (AGWs), but it has not been compared with existing therapies. Evidence of its efficacy is not strong.

Objective  To compare the efficacy and safety of intralesional Mycobacterium w (Mw) vaccine with ...

Viewpoint 
Lola V. Stamm, PhD
Yaws is the most common and severe of the endemic treponematoses (ie, yaws, begel, and pinta).1- 3 This chronic, neglected tropical disease is caused by a noncultivable, spiral-shaped bacterium that is very closely related (approximately 99.8%) to the agent of venereal syphilis, Treponema pallidum subspecies pallidum (Table). Yaws primarily affects ...
Topics: yaws

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