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 Showing 1-20 of 81 Articles

Partial histological tumor regression in primary melanoma is a rather frequent event and has been reported in 10% to 35% of primary melanomas. Partial histological tumor regression is defined as an area within the tumor where melanoma cells have disappeared and are substituted by scarring and melanophages.1...

Original Investigation  FREE
Simone Ribero, MD, PhD; Maria Rosaria Gualano, MD; Simona Osella-Abate, ScD; Giacomo Scaioli, MD; Fabrizio Bert, MD; Martina Sanlorenzo, MD; Elena Balagna, MD; Maria Teresa Fierro, MD; Giuseppe Macripò, MD; Anna Sapino, MD; Roberta Siliquini, MD; Pietro Quaglino, MD

Importance  The prognostic significance of regression in primary melanoma has been debated for many years. There is no consensus regarding the need for sentinel lymph node (SLN) biopsy when regression is present within the primary tumor.

Objective  To review the evidence that regression may affect SLN ...

Original Investigation 
Ikumi Nakamura, MD; Yoshiyuki Kariya, MD, PhD; Etsuko Okada, MD, PhD; Masahito Yasuda, MD, PhD; Shigetaka Matori, MD; Osamu Ishikawa, MD, PhD; Hiroshi Uezato, MD, PhD; Kenzo Takahashi, MD, PhD
Includes: Supplemental Content

Importance  Dermatofibrosarcoma protuberans (DFSP) is a rare skin cancer that develops in the deep dermis to subcutaneous adipose tissues. A COL1A1-PDGFB gene fusion, leading to the constitutive expression of PDGFB, is the tumorigenic mechanism in most DFSP cases.

Objectives  To evaluate the specificity of PDGFB expression ...

Case Report/Case Series 
Nika Cyrus, MD; Adam B. Blechman, MD; Matthew Leboeuf, MD; Elizaveta A. Belyaeva, MD; Maurits N. C. de Koning, PhD; Koen D. Quint, MD, PhD; John J. Stern, MD

Importance  Cutaneous verruca vulgaris lesions (warts) and oral squamous cell papillomas are common lesions caused by human papillomavirus (HPV). Multiple reports have described cases of wart resolution following quadrivalent HPV vaccination. We report the case of a patient with chronic oral papillomas with resolution after quadrivalent HPV ...

JAMA Dermatology Clinicopathological Challenge 
Yuxin Evelyn Tay, MBBS, MRCP; Inny Busmanis, MBBS, FRCPA, FAMS; Haur Yueh Lee, MRCP

An elderly woman with progressive, painful blisters, ulcers of the groin, and enlargement of the tongue was found to have circinate purpuric patches with erosions on the natal cleft and buttocks. What is the diagnosis?

Chiho Horie, MD; Yoko Kano, MD, PhD; Takayo Mitomo, MD; Tetsuo Shiohara, MD, PhD

This case report describes the possible involvement of Mycoplasma fermentans in the development of nonsexually acquired genital ulceration (Lipschütz ulcers) in 3 young female patients.

Original Investigation  FREE
Nely Aldrich, MD; Meg Gerstenblith, MD; Pingfu Fu, PhD; Marie S. Tuttle, MD; Priya Varma, BS; Erica Gotow, BS; Kevin D. Cooper, MD; Margaret Mann, MD; Daniel L. Popkin, MD, PhD

Importance  To our knowledge, this is the first study on rosacea to formally define genetic and environmental contributions.

Objectives  To study a cohort of identical and fraternal twins to determine whether genetic factors contribute to rosacea development and, if genetic factors are present, quantitatively estimate the ...

JAMA Dermatology Clinicopathological Challenge 
Maria Encarnacion Gomez Sánchez, MD; Joaquin Bartolomé Alvarez, MD; Silvia Herrera León, MD

A 12-year-old boy presents with a 3-month history of ulcerated lesions on the dorsal aspect of his feet after traveling. What is your diagnosis?

Research Letter 
Jerome Goddard, PhD; J. Santos Portugal, BS

This study demonstrates the development of itchy erythematous papules and vesicles within 48 hours of larval Amblyomma americanum (lone star tick) attachment to human volunteers.

Hwee Chyen Lee, MRCP; Khor Jia Ker, MRCP; Wei-Sheng Chong, FRCP

This case report describes a case of oral malignant acanthosis nigricans and tripe palms associated with renal urothelial carcinoma.

Original Investigation  FREE
Shirin Bajaj, BA; Stephen W. Dusza, DrPH; Michael A. Marchetti, MD; Xinyuan Wu, BA; Maira Fonseca, BS; Kivanc Kose, PhD; Johanna Brito, MD; Cristina Carrera, MD; Vanessa P. Martins de Silva, MD; Josep Malvehy, MD; Susana Puig, MD, PhD; Sarah Yagerman, MD; Tracey N. Liebman, MD; Alon Scope, MD; Allan C. Halpern, MD, MSc; Ashfaq A. Marghoob, MD
Includes: Supplemental Content

Importance  Although nevi with a peripheral rim of globules (peripheral globular nevi [PGN]) observed with dermoscopy are associated with enlarging melanocytic nevi, their actual growth dynamics remain unknown. Because change is a sensitive but nonspecific marker for melanoma, beginning to understand the growth patterns of nevi may ...

JAMA Dermatology Clinicopathological Challenge 
Julia A. Curtis, MD; Scott R. Florell, MD; Jamie Zussman, MD

A woman in her 70s presented with rough sandpapery skin that had been present for 2½ years. What is the diagnosis?

Research Letter 
Alexander Skojec, BS; Galen Foulke, MD; Joslyn S. Kirby, MD, MS

This database analysis shows that the mean average wholesale price and copayment for generic topical corticosteroids are not proportional to potency and that larger units are more cost effective.

Li-Yu Lin, MD, MPH; Chao-Chun Yang, MD, PhD; Jau-Yn Wan, BS; Tsung Chain Chang, PhD; Julia Yu-Yun Lee, MD

This case report describes the occurrence of a cutaneous infection caused by plant pathogen Colletotrichum gloeosporioides that was successfully treated with oral itraconazole.

Original Investigation  FREE
Howa Yeung, MD; Sara Farber, BA; Belinda K. Birnbaum, MD; Jonathan Dunham, MD; Alexis Ogdie, MD, MSCE; Karen C. Patterson, MD; Aimee S. Payne, MD, PhD; Mary K. Porteous, MD; Milton D. Rossman, MD; Rebecca Sharim, MD; Junko Takeshita, MD, PhD; Victoria P. Werth, MD; Daniel B. Shin, MS; Sarah Price, BA; Misha Rosenbach, MD
Includes: Supplemental Content

Importance  Dermatologists, pulmonologists, and rheumatologists study and treat patients with sarcoidosis with cutaneous manifestations. The validity of cutaneous sarcoidosis outcome instruments for use across medical specialties remains unknown.

Objective  To assess the reliability and validity of cutaneous sarcoidosis outcome instruments for use by dermatologists and nondermatologists ...

Case Report/Case Series 
Kian Eftekhari, MD; Richard L. Anderson, MD; Gita Suneja, MD, MSHP; Anneli Bowen, MD; Thomas J. Oberg, MD; Glen M. Bowen, MD

Importance  Various treatment options exist for nonmelanoma skin cancer (NMSC), including topical agents, surgery, or definitive or adjuvant radiation therapy. Recently, electronic surface brachytherapy (ESB) has been described as a noninvasive option for NMSC. We report a case of local recurrence of basal cell carcinoma (BCC) and ...

JAMA Dermatology Clinicopathological Challenge 
Ellen N. Pritchett, MD, MPH; Emily Hejazi, MD, MS; Carrie Ann Cusack, MD

A woman in her 40s with a medical history of pulmonary embolism and deep venous thrombosis presented with a 6-month history of pruritic, pink scaling plaques on her face and neck with subsequent lesions on the chest, abdomen, and back that flared with sun exposure. What is your ...

Julie K. Kim, MD; Adeel Ahmad, MD; M. Angelica Selim, MD; Elise A. Olsen, MD; Adela R. Cardones, MD

This case report describes the occurrence of disseminated cutaneous cytomegalovirus infection in an immunocompromised patient following total body electron beam irradiation for mycosis fungoides.

Original Investigation  FREE
Haley B. Naik, MD, MHSc; Seth M. Steinberg, PhD; Lindsay A. Middelton, RN, CGC; Stephen M. Hewitt, MD, PhD; Rena C. Zuo, BA; W. Marston Linehan, MD; Heidi H. Kong, MD, MHSc; Edward W. Cowen, MD, MHSc
Includes: Supplemental Content

Importance  Cutaneous leiomyomas can be associated with severe paroxysmal pain in which nerve conduction may have a key role. Medical management of painful cutaneous leiomyomas is generally unsatisfactory.

Objective  To assess the efficacy of intralesional botulinum toxin A in the management of pain associated with cutaneous ...

JAMA Dermatology Clinicopathological Challenge 
Felicia E. Ekpo, DO; Thomas L. Cibull, MD; Edidiong Celestine Ntuen Kaminska, MD, MBS

A man in his 50s of Indian descent presented with a pruritic eruption on his scalp, arms, neck, and feet. What is your diagnosis?

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