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 Showing 1-20 of 84 Articles
Joel M. Gelfand, MD, MSCE

Psoriasis is a common, chronic inflammatory disease that is associated with an increased risk of cardiovascular, metabolic, and renal disease in a manner that varies with the severity of psoriasis and is often independent of traditional risk factors for these other diseases.1,2 The clinical significance ...

Original Investigation 
Ann Sophie Lønnberg, MD; Lone Skov, MD, DMSc, PhD; Axel Skytthe, MSc, PhD; Kirsten Ohm Kyvik, MD, PhD, MPM; Ole Birger Pedersen, MD, PhD; Simon Francis Thomsen, MD, DMSc, PhD

Importance  Psoriasis has been shown to be associated with overweight and type 2 diabetes mellitus. The genetic association is unclear.

Objective  To examine the association among psoriasis, type 2 diabetes mellitus, and body mass index (BMI) (calculated as weight in kilograms divided by height in meters ...

Editorial: Psoriasis, Type 2 Diabetes Mellitus, and Obesity; Joel M. Gelfand, MD, MSCE
Review  FREE
Jannett Nguyen, BS; Dorota Z. Korta, MD, PhD; Lance Chapman, MD, MBA; Kristen M. Kelly, MD

Importance  Although cutaneous warts are common lesions, full remission is not always achieved with conventional therapies. Laser modalities including carbon dioxide (CO2), erbium:yttrium-aluminum-garnet (Er:YAG), pulsed dye (PDL), and Nd:YAG have been investigated as alternative treatments for warts.

Objective  To review the use and efficacy ...

JAMA Dermatology Clinicopathological Challenge 
Amanda J. Laska, MD; William A. Miller, MD; Arturo R. Dominguez, MD

A 32-year-old male with a history of end-stage liver disease secondary to alcoholic cirrhosis presented with a 2-week history of a skin rash that developed at a facility where he was being treated for hepatic encephalopathy; the lesions began on his face, spread to his thighs, and were ...

Research Letter 
Drew J. B. Kurtzman, MD; Natalie A. Wright, MD; Janice Lin, MD; Alisa N. Femia, MD; Joseph F. Merola, MD, MMSc; Mital Patel, MD; Ruth Ann Vleugels, MD, MPH

This case series of 3 patients evaluates the utility of tofacitinib treatment for cutaneous dermatomyositis.

Original Investigation 
Audrey A. Jacobsen, BA; Adam S. Aldahan, BS; Olivia B. Hughes, BS; Vidhi V. Shah, BA; John Strasswimmer, MD, PhD

Importance  Hedgehog pathway inhibitors (HPIs) were made available by US Food and Drug Administration approval in 2012 for vismodegib and 2015 for sonidegib. Both target the Smoothened molecule and are indicated for locally advanced basal cell carcinoma (laBCC) and metastatic basal cell carcinoma (mBCC).

Objective  To ...

Original Investigation 
Rajiv Kumar, MPharm, PhD; Sunil Dogra, MD, DNB, FRCP; Basant Amarji, MPharm, PhD; Bhupinder Singh, MPharm, PhD; Suresh Kumar;  Sharma, MSc, MPhil, PhD; Keshavamurthy Vinay, MD; Rahul Mahajan, MD; O. P. Katare, MPharm, PhD
Includes: Supplemental Content

Importance  Attempts to use topical cyclosporine in treatment of psoriasis have failed because of unfavorable physicochemical properties and inappropriate formulation design of the conventional dosage forms.

Objective  To evaluate the efficacy of topical cyclosporine using liposomal nanocarriers (lipogel) in limited chronic plaque psoriasis.

Design, Setting, and, ...

Brief Report 
Akiko Arakawa, MD, PhD; Thomas Ruzicka, MD; Jörg C. Prinz, MD

Importance  Generalized pustular psoriasis von Zumbusch type (GPP) is the most severe manifestation of psoriasis. The etiology of GPP is only partially understood, and GPP lacks approved treatments. Loss-of-function mutations in the interleukin 36 (IL-36) receptor antagonist (IL36RN), an inhibitor of innate immune activation in ...

JAMA Dermatology Clinicopathological Challenge 
Nicole Knöpfel, MD; Ana Martín-Santiago, MD; Elsa Puerto-Carranza, MD

An adolescent girl with no relevant family history was referred to the dermatology pediatric unit for evaluation of multiple asymptomatic lesions on her tongue that gradually developed since the first years of life; both lips were enlarged and felt nodular. What is your diagnosis?

Research Letter 
Andrew J. Marek, MS; Michael E. Ming, MD, MSCE; Edmund K. Bartlett, MD; Giorgos C. Karakousis, MD; Emily Y. Chu, MD, PhD

This study analyzes sentinel lymph node biopsy in a subset of patients with melanomas smaller than 1 mm.

Original Investigation 
Cristina Carrera, MD, PhD; Michael A. Marchetti, MD; Stephen W. Dusza, DrPH; Giuseppe Argenziano, MD; Ralph P. Braun, MD; Allan C. Halpern, MD; Natalia Jaimes, MD; Harald J. Kittler, MD; Josep Malvehy, MD; Scott W. Menzies, MBBS, PhD; Giovanni Pellacani, MD; Susana Puig, MD; Harold S. Rabinovitz, MD; Alon Scope, MD; H. Peter Soyer, MD; Wilhelm Stolz, MD; Rainer Hofmann-Wellenhof, MD; Iris Zalaudek, MD; Ashfaq A. Marghoob, MD

Importance  The comparative diagnostic performance of dermoscopic algorithms and their individual criteria are not well studied.

Objectives  To analyze the discriminatory power and reliability of dermoscopic criteria used in melanoma detection and compare the diagnostic accuracy of existing algorithms.

Design, Setting, and Participants  This was ...

Centaine Snoswell, BPharm, MPH; Anna Finnane, PhD; Monika Janda, PhD; H. Peter Soyer, MD; Jennifer A. Whitty, PhD

Importance  Teledermatology is a topical clinical approach being tested in Australia and elsewhere. With most dermatologists residing in metropolitan areas, teledermatology provides an apparent low-cost and convenient means of access for individuals living outside these areas. It is important that any proposed new addition to a health ...

JAMA Dermatology Clinicopathological Challenge 
Hannah Song, BA; Kristina J. Liu, MD; Jennifer T. Huang, MD

A teenage girl presented with hand and foot swelling and pain in areas of sun exposure after playing golf; she had a 2-year history of similar but milder skin eruptions. What is your diagnosis?

Howa Yeung, MD; Kevin Man-Hin Luk, BS; Suephy C. Chen, MD, MS

This case report describes a patient who used a baseball cap for scalp photoprotection.

Elisabeth M. Roider, MD; David E. Fisher, MD, PhD

A key gene that regulates pigmentation in humans is the melanocortin-1-receptor gene (MC1R; OMIM 155555), which encodes a 7-transmembrane G-protein–coupled receptor that regulates adenosine 3′, 5′ cyclic monophosphate (cAMP) levels in melanocytes. MC1R is activated by melanocyte stimulating hormone (MSH), which is secreted by UV-irradiated ...

The American Board of Dermatology (ABD) launched its Maintenance of Certification (MOC) program for board-certified dermatologists in 2006 in response to the American Board of Medical Specialties mandate that participating boards create and oversee a MOC program for certified diplomates. The purpose behind MOC was and continues to ...

Original Investigation 
Judith Wendt, MD, PhD; Sabine Rauscher, MSc; Sebastian Burgstaller-Muehlbacher, PhD; Ingrid Fae, MSc; Gottfried Fischer, MD; Hubert Pehamberger, MD; Ichiro Okamoto, MD
Includes: Supplemental Content

Importance  Despite the unquestioned relationship of UV radiation (UVR) exposure and melanoma development, UVR-independent development of melanoma has only recently been described in mice. These findings in mice highlight the importance of the genetic background of the host and could be relevant for preventive measures in humans....

Editorial: Red Hair, Light Skin, and UV-Independent Risk for Melanoma; Elisabeth M. Roider, MD; David E. Fisher, MD, PhD
JAMA Dermatology Clinical Evidence Synopsis 
Daihung Do, MD; April W. Armstrong, MD, MPH

Clinical Question  What are the screening guidelines for hepatitis B virus (HBV) infection for asymptomatic, nonpregnant adolescents and adults in the United States?

Bottom Line  Patients with a high risk of infection, such as those with human immunodeficiency virus (HIV), who use injection drugs, or who ...

JAMA Dermatology Clinicopathological Challenge 
Lawrence Feigenbaum, MD; Kiran Motaparthi, MD; Mark Fradin, MD

A man in his 70s presented with a 4.0-cm linear plaque with an 8.0-mm erythematous nodule on one end on his right upper abdomen; the lesion appeared 2 months prior and had been mildly itchy. What is your diagnosis?

Original Investigation 
Joslyn S. Kirby, MD, MS, MEd; Amber Delikat, BS; Douglas Leslie, PhD; Jeffrey J. Miller, MD, MBA
Includes: Supplemental Content

Importance  Recent legislation encourages alternative payment models, such as bundled payments. There are no clear recommendations on bundled payment design, and research on bundled payments for dermatologic care is limited.

Objective  To investigate several methods to develop bundled payment models for actinic keratosis (AK) management and ...

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