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 Showing 1-20 of 72 Articles

Importance  Accurate estimation of the incidence and prevalence of each subtype of epidermolysis bullosa (EB) is essential before clinical trials can be designed and sufficient funding allocated by government agencies and third-party insurers for the care of these individuals.

Objective  To determine the incidence and prevalence ...

Original Investigation  FREE
Alexander Kreuter, MD; Christos Siorokos, MD; Frank Oellig, MD; Steffi Silling, PhD; Herbert Pfister, PhD; Ulrike Wieland, MD
Includes: Supplemental Content

Importance  Human papillomavirus (HPV)-induced anogenital lesions are very frequent in men who have sex with men (MSM) who are HIV-positive (HIV+). Anogenital warts (AGWs) are considered benign lesions caused by low-risk HPV-types, whereas anogenital dysplasias are potential cancer precursors associated with high-risk HPV-types. Both types of lesions ...

Research Letter 
Marie Perier-Muzet, MD; Amélie Boespflug, MD; Nicolas Poulalhon, MD; Julie Caramel, PhD; Anne-Laure Breton, MD; Luc Thomas, MD, PhD; Stephane Dalle, MD, PhD

This observational study investigates nevi changes after combined BRAF inhibitor and mitogen-activated protein kinase pathway inhibitor therapy in patients with metastatic melanoma.

Observation 
Chi-Feng Yen, MD; Hung-Bun Lam, MD

This case report describes the use of CMF chemotherapy to treat triple-negative breast cancer with carcinoma erysipelatoides.

Comment & Response 
Roshini S. Abraham, PhD; Lawrence E. Gibson, MD

To the Editor The authors would like to notify the editors and readers of an inadvertent error recently noted in the description of the CECR1 mutations provided in our report.1 The genetic testing was performed as a clinical test at a reference laboratory and the complementary DNA ...

Correction  FREE

In the Case Report titled “Dermatologic Features of ADA2 Deficiency in Cutaneous Polyarteritis Nodosa”1 published in the November issue of JAMA Dermatology, an error was reported in the description of one of the CECR1 mutations. The correct mutation description is c.984C>A, and not c.1159C>A as originally ...

Editorial  FREE
Susan M. Swetter, MD; Alan C. Geller, MPH, RN; Allan C. Halpern, MD

This Editorial discusses the US Preventive Services Task Force recommendation statement on screening for skin cancer and what it means for primary care clinicians and dermatologists.

Original Investigation 
G. Thomas Ray, MBA; Martin Kulldorff, PhD; Maryam M. Asgari, MD, MPH

Importance  Rates of skin cancer, including basal cell carcinoma (BCC), the most common cancer, have been increasing over the past 3 decades. A better understanding of geographic clustering of BCCs can help target screening and prevention efforts.

Objective  Present a methodology to identify spatial clusters of ...

Brief Report 
Mark G. Kirchhof, MD, PhD; Aaron Wong, MD; Jan P. Dutz, MD
Includes: Supplemental Content

Importance  Drug-induced hypersensitivity syndrome (DIHS), also known as drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, is a potentially life-threatening reaction to medications with a mortality rate up to 10%. Standard therapy involves the use of systemic corticosteroids with tapering doses extending up to 9 months ...

Brief Report 
Tracy Funk, MD; Young Lim, BS; Ann M. Kulungowski, MD; Lori Prok, MD; Timothy M. Crombleholme, MD, MA; Keith Choate, MD, PhD; Anna L. Bruckner, MD
Includes: Supplemental Content

Importance  Congenital hemangiomas are uncommon benign vascular tumors that present fully formed at birth. They are rarely associated with transient hematologic abnormalities, which are typically less severe than the Kasabach-Merritt phenomenon associated with kaposiform hemangioendotheliomas. Congenital hemangiomas are typically solitary and have not been reported to occur ...

Research Letter 
Alessandra Haskin, BA; Alexander H. Fischer, MPH; Ginette A. Okoye, MD

This study examines the prevalence of Firmicutes in bacterial cultures of purulent drainage from hidradenitis suppurativa lesions and explores its potential association with body mass index.

Observation 
Laure Frumholtz, MD; Jennifer Roux, MD; Martine Bagot, MD, PhD; Michel Rybojad, MD; Jean-David Bouaziz, MD, PhD

This case report describes the treatment of generalized deep morphea with everolimus.

Correction  FREE

In the Systematic Review titled “Laser Treatment of Nongenital Verrucae,”1 published online April 27, 2016, an author’s middle initial was omitted. The correct spelling is “Lance W. Chapman.” This article was corrected online.

Original Investigation 
Veronica J. Shi, MD; Nemanja Rodic, MD, PhD; Scott Gettinger, MD; Jonathan S. Leventhal, MD; Julia P. Neckman, MD; Michael Girardi, MD; Marcus Bosenberg, MD, PhD; Jennifer N. Choi, MD

Importance  Antagonist antibodies to programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) have shown remarkable activity in multiple tumor types. Recent US Food and Drug Administration approval of such agents for advanced melanoma, non–small cell lung cancer, and renal cell carcinoma has hastened ...

Brief Report 
Joanna H. Tu, BA; Sarah L. Sheu, MD; Joyce M. Teng, MD, PhD

Importance  Erythropoietic protoporphyria (EPP) is a rare hereditary disease of heme biosynthesis that manifests as severe photosensitivity and hepatotoxicity. There have been no effective treatments to date. Cimetidine has been shown to inhibit heme biosynthesis and results in symptomatic improvement in patients with acute intermittent porphyria (AIP) ...

Research Letter 
Melissa Shive, MD, MPH; Derek Ho, BS; Olivia Lai, BS; Andrew Mamalis, MS; Kevin M Miller, MD; Jared Jagdeo, MD, MS

This case study examines the visual phenomenon associated with why blue nevi appear blue.

Original Investigation 
Kasper Fjellhaugen Hjuler, MD; Morten Bøttcher, MD, PhD; Christian Vestergaard, MD, PhD, DMSc; Hans Erik Bøtker, MD, PhD; Lars Iversen, MD, DMSc; Knud Kragballe, MD, DMSc
Includes: Supplemental Content

Importance  Inflammatory pathways of psoriasis share similarities with the mechanisms identified in atherosclerosis, and the association between psoriasis and cardiovascular disease due to accelerated coronary artery disease is well established. The effect of anti-inflammatory drugs on the development of coronary atherosclerosis remains essentially unknown.

Objective  To ...

Original Investigation 
Gary S. Chuang, MD; William Farinelli, BA; David C. Christiani, MD; Robert F. Herrick, ScD; Norman C. Y. Lee, PhD; Mathew M. Avram, MD

Importance  Potentially harmful chemicals are released when tissues are vaporized. Laser hair removal (LHR) causes heating and often vaporization of hairs, producing both a signature malodorous plume and visible particulates.

Objective  To characterize the chemical composition and quantify the ultrafine particle content of the plume generated ...

Original Investigation 
Shuai Xu, MD, MSc; Michael Kwa, BA; Ashwin Agarwal, MD; Alfred Rademaker, PhD; Roopal V. Kundu, MD
Includes: Supplemental Content

Importance  Sunscreen use is a modifiable behavior that can help reduce the risk for skin cancer, prevent sunburns, mitigate photoaging, and treat photosensitive dermatoses. A better understanding of consumer sunscreen preferences would inform dermatologists in their own recommendations.

Objective  To determine the characteristics and the most ...

Brief Report 
Iana Turcan, MD; Anna M. G. Pasmooij, PhD; Peter C. Van den Akker, MD, PhD; Henny Lemmink, PhD; Richard J. Sinke, PhD; Marcel F. Jonkman, MD, PhD

Importance  Epidermolysis bullosa simplex (EBS) is a group of clinically and genetically diverse mechanobullous genodermatoses characterized by the fragility of skin and mucous membranes. Recently, mutations in EXPH5 encoding exophilin-5 (also known as Slac2-b, an effector protein involved in intracellular vesicle trafficking and exosome secretion) have been ...

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