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 Showing 1-20 of 84 Articles
Case Report/Case Series 
Carrie Ann Cusack, MD; Rohit Nijhawan, MD; Brett Miller, MD; Mira Henien, BS; Gregory Malat, PharmD; Alden Doyle, MD; Mark Abdelmalek, MD

Importance  Immunosuppressed patients with solid organ transplants have an increased risk for nonmelanoma skin cancer. Vismodegib has been reported to be effective for select locally advanced or metastatic basal cell carcinomas. However, there is no data documenting the use and safety of vismodegib in immunosuppressed organ transplant ...

Research Letter 
Michael T. Cosulich, MD; Matthew A. Molenda, MD; Eliot Mostow, MD, MPH; Ashish C. Bhatia, MD; Robert T. Brodell, MD
Lipomas are benign proliferations of mature fat that are occasionally tender. Common treatment approaches include elliptical excision, liposuction, and injection lipolysis. For most lipomas, we favor the minimal incision or “squeeze” technique, whereby lipomas are expressed through a small scalpel or punch incision.1,2 To our knowledge, the utilization rate of ...
Topics: lipoma
Research Letter 
Jennifer L. Hay, PhD; Mallorie Gordon, MA; Yuelin Li, PhD
First-degree relatives (FDRs) of patients with melanoma may be among the first to seek melanoma genetic risk information.1 Testing may subsequently prompt useful discussions regarding melanoma risk, early detection, and prevention with multiple family members. To explore this potential, this study examined the intended discussions of FDRs of patients with ...
Observation 
Cristina Thomas, BA; Pedram Yazdan, MD; Jonathan A. Cotliar, MD
We report a case of adult staphylococcal scalded skin syndrome (SSSS) superimposed on acute graft-vs-host disease (GVHD) and discuss the unique histologic features of both conditions seen on skin biopsy.
Observation 
Peiqi Su, MBBS (UK, Imperial College), MRCP(UK); Taige Cao, MBBS; Mark B. Y. Tang, MBBS, FRCP, FAMS; Hong Liang Tey, MBBS, MRCP(UK)
Optical coherence tomography (OCT) is a noninvasive imaging technique that allows real-time high-definition cross-sectional visualization of tissues. Conventional OCT was introduced in dermatology in 1997 and has shown benefit in evaluating malignant neoplasms and inflammatory skin disorders.1,2 High-definition OCT (HD-OCT) scanners have recently been developed; they provide a higher resolution ...
JAMA Dermatology Clinicopathological Challenge 
Corinne Atty, DO; Victoria M. Alagiozian-Angelova, MD; Areta Kowal-Vern, MD
Topics: dermatology; burns
Original Investigation  FREE
April W. Armstrong, MD, MPH; Mary Ann Johnson, MD; Steven Lin, MD; Emanual Maverakis, MD; Nasim Fazel, MD, DDS; Fu-Tong Liu, MD, PhD

Importance  New models of health care delivery for dermatological care have the potential to increase access and improve patient-centered outcomes.

Objective  To compare effectiveness of a direct-access, online model for follow-up dermatologic care in pediatric and adult patients with atopic dermatitis with that of in-person office ...

Case Report/Case Series 
Shirwa Sheik Ali, BSc; Allison L. Goddard, MD; Jason J. Luke, MD; Hilary Donahue, PA; Derrick J. Todd, MD, PhD; Andrew Werchniak, MD; Ruth Ann Vleugels, MD, MPH

Importance  Ipilimumab, a human monoclonal antibody targeted against cytotoxic T-lymphocyte antigen 4, has shown promise in the treatment of metastatic melanoma. However, given its mechanism of action, immune-related adverse effects have been reported with this therapy. Despite increasing reports of immune-related adverse effects related to ipilimumab therapy, ...

Comment & Response 
Vanessa L. Pascoe, BA; Alexandra B. Kimball, MD, MPH
To the Editor In their recent article, “Scope of Physician Procedures Independently Billed by Mid-Level Providers in the Office Setting,” Coldiron and Ratnarathorn1 describe the expanding scope of dermatologic mid-level practitioners. Specifically, in 2012 physician assistants (PAs) and nurse practitioners (NPs) performed and billed independently for more than 4 million ...
JAMA Dermatology Clinicopathological Challenge 
Syril Keena T. Que, MD; Brett Sloan, MD; Soheil Sam Dadras, MD
Original Investigation 
Junko Takeshita, MD, PhD; Shuwei Wang, MD; Daniel B. Shin, MS; Nehal N. Mehta, MD, MSCE; Stephen E. Kimmel, MD, MSCE; David J. Margolis, MD, PhD; Andrea B. Troxel, ScD; Joel M. Gelfand, MD, MSCE

Importance  Hypertension is prevalent among patients with psoriasis. The effect of psoriasis and its severity on hypertension control is unknown.

Objective  To determine the association between uncontrolled blood pressure and psoriasis, both overall and according to objectively measured psoriasis severity, among patients with diagnosed hypertension.

Design, ...

Case Report/Case Series 
Marina Vita, PhD; Julie C. Tisserand, MSCI; Isaure Chauvot de Beauchêne, PhD; Nicolas Panel, MSCI; Luba Tchertanov, PhD; Julie Agopian, MSCI; Lenaïg Mescam-Mancini, MD; Bernard Fouet, MD; Béatrice Fournier, MD; Patrice Dubreuil, PhD; François Bertucci, MD, PhD; Paulo De Sepulveda, PhD
Includes: Supplemental Content

Importance  The KIT receptor is mutated in approximately 15% of acral, mucosal, and chronic, sun-damaged melanomas. The status of KIT mutations is of interest because they usually are mutually exclusive with N-RAS and B-RAF mutations and because of the availability of KIT kinase inhibitors in the clinic. ...

Case Report/Case Series 
Loren Gorcey, BA; Elizabeth A. Gordon Spratt, MD; Marie C. Leger, MD, PhD

Importance  Alopecia universalis is an uncommon form of alopecia areata (AA) involving hair loss over the entire scalp and body and is often difficult to treat. Tumor necrosis factor (TNF) inhibitors have been largely unsuccessful in treating AA and have been reported to induce or worsen AA ...

Case Report/Case Series 
Tarun Mehra, MD; Kristian Ikenberg, MD; Rudolf Maria Moos, MD; Rudolf Benz, MD; Gayathri Nair, MD; Urs Schanz, MD; Eugenia Haralambieva, MD; Wolfram Hoetzenecker, MD, PhD; Reinhard Dummer, MD; Lars Einar French, MD; Emmanuella Guenova, MD, PhD; Antonio Cozzio, MD, PhD
Includes: Supplemental Content

Importance  The prognosis of advanced cutaneous T-cell lymphoma (CTCL), including Sézary syndrome and mycosis fungoides (MF), is poor. So far, no curative option apart from allogeneic stem cell transplantation is available. Large cell transformation often hallmarks cases with a more aggressive clinical course, and large tumor cells ...

The Cutting Edge 
Heather K. Hamilton, MD; Jeffrey S. Dover, MD, FRCPC; Kenneth A. Arndt, MD
Observation 
G. Thomas Brown, MD, PhD; Edward W. Cowen, MD, MHSc; Chyi-chia Richard Lee, MD
Multiple endocrine neoplasia type 1 (MEN-1) is an autosomal dominant syndrome consisting of endocrine tumors of the parathyroid gland, pituitary gland, and pancreas. MEN-1 is caused by loss of function mutations in the MEN1 gene, which encodes the tumor suppressor protein menin. Cutaneous collagenomas and facial angiofibromas also have been ...
JAMA Dermatology Clinicopathological Challenge 
Daniel Zaghi, MD, MS; Daniel Witheiler, MD; Alan M. Menter, MD
Case Report/Case Series 
Curtis Lamar Hardy, DO; Jonathan S. Glass, MD; Timothy Sorrells, MD; Luke C. Nicholas, MD

Importance  The breakdown of previously inserted intravascular devices can lead to microemboli that can clinically mimic the symptoms of common disorders, such as senile purpura, and have subtle histologic findings. However, device failure can occur gradually and start months after placement. If not identified early, microemboli to ...

The Cutting Edge 
Michael Kasperkiewicz, MD; Sven Süfke, MD; Enno Schmidt, MD, PhD; Detlef Zillikens, MD
JAMA Dermatology Clinicopathological Challenge 
Michael Cunningham, MS; Ryan Rogers, MD; Laura Greene, MD

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