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 Showing 1-20 of 86 Articles
Case Report/Case Series 
Tomoko Nakahara, MD; Atsushi Takagi, MD, PhD; Jun Yamagami, MD, PhD; Koji Kamiya, MD, PhD; Yumi Aoyama, MD, PhD; Keiji Iwatsuki, MD, PhD; Shigaku Ikeda, MD, PhD
Includes: Supplemental Content

Importance  Pemphigus vulgaris (PV) is a disease that features blistering of the skin and mucous membranes caused by autoantibodies directed against desmoglein 3 (Dsg3) and/or desmoglein 1 (Dsg1). Indirect immunofluorescence (IIF) and enzyme-linked immunosorbent assay (ELISA) are 2 methods that are widely used to measure Dsg3 or ...

Case Report/Case Series 
Katie S. Payne, BS; Karen Schilli, MS; Katlyn Meier; Ryan K. Rader, BS; Jonathan A. Dyer, MD; James W. Mold, MD, MPH; Jonathan A. Green, PhD; William V. Stoecker, MD, MS

Importance  Bites from the brown recluse spider (BRS) can cause extreme pain. We propose cytokine release as a cause of the discomfort and a central mechanism through glial cell upregulation to explain measured pain levels and time course.

Observations  Twenty-three BRS bites were scored at a ...

Case Report/Case Series 
Joseph F. Sobanko, MD; John Fischer, MD; Jeremy R. Etzkorn, MD; Christopher J. Miller, MD
Includes: Supplemental Content

Importance  Appropriate coverage of defects that expose tendon, joints, and/or neurovascular structures is necessary to preserve optimal hand function. Local, random-pattern flaps and skin grafts may be inadequate because of the hand’s finite skin reservoir or the presence of a poorly vascularized and mobile wound bed. Described ...

Research Letter 
Sheila Krishna, MD; Eric Ambrecht, PhD; Ian A. Maher, MD
More than 3 million nonmelanoma skin cancers (NMSCs) are diagnosed annually in the United States.1,2 The incidence of malignant melanoma (MM) has increased annually by 2.4%.3 Open field activities in youth are a major source of sun exposure, which leads to skin cancer later in life.4- 6 Few studies exist ...
Topics: soccer; cyclic amp
Observation 
Karolyn A. Wanat, MD; Erika Reid, MD; William Kamiyango, MD; Nader Kim El-Mallawany, MD; Carrie L. Kovarik, MD
Bacillary angiomatosis (BA) is a life-threatening infection caused by gram-negative organisms of the genus Bartonella that can be cured with appropriate therapy. The clinical manifestations of this infection are diverse, and a high index of suspicion and histopathologic analysis are often required to make the diagnosis.1
Observation 
Piotr Brzezinski, MD, PhD; Anca Chiriac, MD, PhD
Observation 
A. Bianca Stashak, BS; Rachel Laarman, MD; Garth R. Fraga, MD; Deede Y. Liu, MD
We report the case of a patient with a history of malignant melanoma who presented to our clinic with a “new brown spot” on her heel.
Case Report/Case Series 
Mark Tye Haeberle, MD; Patricia Todd, MD; Jeffrey P. Callen, MD; Soon Bahrami, MD

Importance  Nontuberculous mycobacterial infections of the skin can be seen in cases of immunosuppression and/or traumatic implantation of contaminated objects. Surgical settings with appropriate sterilization techniques have been immune to these types of infections. We report a case of nosocomially derived infection from a sterile procedure.

Observations...

Research Letter 
Sarah Yagerman, MD; Eileen Flores, MPH; Klaus Busam, MD; Mario Lacouture, MD; Ashfaq A. Marghoob, MD
Includes: Supplemental Content
Patients taking BRAF inhibitors develop new primary melanomas and nevi. Many of these neoplasms are BRAF wild-type,1 which may be due to the paradoxical activation of the RAF/MEK/ERK pathway via an alternative driver mutation, similar to the mechanism involved in inducing the development of squamous cell carcinomas in these patients.2 ...
Research Letter 
Bobbye J. Thompson, MD; Megan Furniss, DO; Wenjing Zhao, PhD; Bibhas Chakraborty, PhD; Julian Mackay-Wiggan, MD, MS
Includes: Supplemental Content
Rosacea is a chronic skin disorder characterized by facial flushing, persistent erythema, telangiectasias, and inflammatory papules and pustules. In addition to the physical manifestations, rosacea may contribute to lower self-esteem, thereby having significant psychosocial implications.1 Some patients do not respond to conventional treatments for rosacea or are unable to tolerate ...
Observation 
Justin D. Richey, MD; Thomas A. Graham, MD, PhD; Terrence Katona, DO; Jeffrey B. Travers, MD, PhD
Vismodegib is approved by the US Food and Drug Administration for the treatment of unresectable basal cell carcinoma (BCC) as well as for Gorlin syndrome (basal cell nevus syndrome).1,2
Observation 
David Khalil, MD; Brett King, MD, PhD
Orbital fat herniation frequently presents as a prominent unilateral mass near the lateral canthus of the eye, where it poses a fundamental question: benign or malignant? As dermatologists, we will encounter this seldom-described benign mass. The differential diagnosis, pathophysiology, and treatment options are discussed in the context of a patient ...
Topics: hernias; orbital fat; eye
JAMA Dermatology Clinicopathological Challenge 
Harjot Singh Maan, MD; Glynis Scott, MD; Mary Gail Mercurio, MD
Original Investigation 
Anne Pham-Ledard, MD; Marie Beylot-Barry, MD, PhD; Coralie Barbe, MD; Marion Leduc, MS; Tony Petrella, MD; Béatrice Vergier, MD, PhD; Fabian Martinez, MS; David Cappellen, PhD; Jean-Philippe Merlio, MD, PhD; Florent Grange, MD, PhD

Importance  The activating mutation of MYD88 L265P is a frequent feature of primary cutaneous diffuse large B-cell lymphoma, leg-type (PCLBCL-LT), reported in up to 69% of the cases. Whether patients with MYD88 mutation display specific clinical and evolutive features has not been evaluated.

Objective  To identify ...

Original Investigation 
Gil Yosipovitch, MD; Kyle C. Mills, MD; Leigh A. Nattkemper, MS; Ashley Feneran, DO; Tey Hong Liang, MD; Brett M. Lowenthal, MD; Daniel J. Pearce, MD; Phillip M. Williford, MD; Omar P. Sangueza, MD; Ralph B. D’Agostino Jr, PhD
Includes: Supplemental Content

Importance  This study highlights a simple bedside evaluation of itch and pain for suspicious skin lesions.

Objective  To examine the correlation of pain and itch with histologic features of skin cancers.

Design, Setting, and Participants  This large, prospective, clinicopathologic study enrolled patients who filled out ...

Case Report/Case Series 
Nicole M. Cassler, MD; Ashley M. Burris, BS; Josephine C. Nguyen, MD

Importance  Asteatotic eczema (eczema craquelé, xerotic eczema) occurs most frequently in areas of dehydrated skin, most often during the winter months when decreased humidity results in increased water loss from the stratum corneum. We present 5 cases in which asteatotic eczema was found outside of its normal ...

Consensus Statement  FREE
Joyce M. C. Teng, MD, PhD; Edward W. Cowen, MD, MHSc; Mari Wataya-Kaneda, MD, PhD; Elizabeth S. Gosnell, DMD; Patricia M. Witman, MD; Adelaide A. Hebert, MD; Greg Mlynarczyk, DDS; Keyoumars Soltani, MD; Thomas N. Darling, MD, PhD

Importance  The 2012 International Tuberous Sclerosis Complex Clinical Consensus Conference was convened to update the last consensus statement in 1998. Skin and dental lesions are common in tuberous sclerosis complex (TSC) and are a frequent concern for patients. Recognition of these lesions is imperative for early diagnosis, ...

The volunteer members of the Dermatology and Dentistry Subcommittee of the 2012 International Tuberous Sclerosis Complex Clinical Consensus Conference reviewed publications over a 15-year period ending in 2012 (Figure). By recognizing the transformative use of mammalian target of rapamycin inhibitors and placing it into the context of other treatments, this ...
Observation 
Gabriela Cobos, BS; Inbal Braunstein, MD; Katrina Abuabara, MD; Emily Y. Chu, MD, PhD; William James, MD
Mucinous nevus is a rare entity characterized by mucin deposition in the papillary dermis. Herein we present a case and review the available literature.
Topics: nevus
Observation 
Sarah I. Jawed, BA; Klaus Busam, MD; Xuan Wang, MD, PhD; Steven Horwitz, MD; Christiane Querfeld, MD, PhD
Alemtuzumab, a CD52 monoclonal antibody, is increasingly used for treating advanced cutaneous T-cell lymphomas including Sézary syndrome (SS). While injection site reactions are common, the finding of localized cutaneous hemophagocytosis at the injection site without systemic hemophagocytosis is rare.

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