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 Showing 1-20 of 97 Articles
Case Report/Case Series 
Tania M.  Gonzalez Santiago, MD; Andrey Zavialov, PhD; Janna Saarela, MD, PhD; Mikko Seppanen, MD, PhD; Ann M. Reed, MD; Roshini S. Abraham, PhD; Lawrence E. Gibson, MD

Importance  Mutations in the CERC1 gene associated with deficiency in the ADA2 protein (DADA2) have been implicated in the pathogenesis of cutaneous polyarteritis nodosa (cPAN) and early-onset vasculopathy. DADA2 is not only limited to cPAN and vasculopathy but also includes immunodeficiency that affects several cellular compartments, including ...

Research Letter  FREE
Gery P. Guy Jr, PhD, MPH; Zahava Berkowitz, MSc, MSPH; Dawn M. Holman, MPH; Anne M. Hartman, MS, MA

This analysis of data from the National Health Interview Survey reports significant reductions in indoor tanning among US adults from 2010 to 2013.

Observation 
Olushola Akinshemoyin Vaughn, BA; Molly A. Hinshaw, MD; Joyce M. Teng, MD, PhD

This case report describes a possible solution to the challenge of clinically distinguishing acantholytic dyskeratotic epidermal nevus, often a congenital condition, from Darier disease, which is acquired.

Case Report/Case Series  FREE
Brittany G. Craiglow, MD; Brett A. King, MD, PhD

Importance  Vitiligo is a common condition that is often emotionally devastating for patients. At present, no reliably effective treatments are available.

Observations  Recent advances in the understanding of the pathogenesis of vitiligo suggest that Janus kinase inhibitors may be a therapeutic option. We report a case ...

Research Letter 
Joel Hillhouse, PhD; Jerod L. Stapleton, PhD; L. Carter Florence, MPH; Sherry Pagoto, PhD

This survey found that many young women use indoor tanning facilities that are not tanning-only salons and engage in risky tanning behavior.

Research Letter 
Pauline Laly, MD; Saskia Ingen-Housz-Oro, MD; Marie Beylot-Barry, MD, PhD; Laurence Verneuil, MD, PhD; Henri Adamski, MD; Pauline Brice, MD; Martine Bagot, MD, PhD

This retrospective study of patients with cutaneous anaplastic large cell lymphoma reports the efficacy of vinblastine as monotherapy for this condition.

Observation 
Chiaki Murase, MD; Michihiro Kono, MD, PhD; Kazue Nakanaga, PhD; Norihisa Ishii, MD, PhD; Masashi Akiyama, MD, PhD

This case report details successful use of negative-pressure wound therapy for treatment of an advanced Buruli ulcer and suggests that such treatment might be effective in similar future cases.

Viewpoint 
Michael A. Marchetti, MD; Esther Chung, BA; Allan C. Halpern, MD

This Viewpoint discusses the benefits and risks of increased screening for acral lentiginous melanoma in dark-skinned individuals.

JAMA Dermatology Clinicopathological Challenge 
Chien-Ho Chu, MD; Chia-Yu Chou, MD; Yu-Pin Cheng, MD
Research Letter  FREE
Betty Y. Kong, PhD; Sarah L. Sheu, MD; Roopal V. Kundu, MD

UV-A radiation is associated with accelerated skin aging, while UV-B exposure is associated with sunburns.1 Exposure to both types of radiation is a major risk factor for the development of skin cancer.1 By protecting the skin from UV light, sunscreen protects against these negative sequelae of ...

Research Letter 
Esther Chung, BA; Ashfaq A. Marghoob, MD; Cristina Carrera, MD, PhD; Michael A. Marchetti, MD

This review of previously acquired data reports that the use of a 2-step algorithm and pattern analysis in dermoscopy can identify benign cutaneous melanoacanthoma in patients with seborrheic keratosis.

Observation 
Ryan Gillihan, BS; Tony Nguyen, MD; Ryan Fischer, MD; Anand Rajpara, MD; Daniel Aires, MD

We describe a case of compensatory vasodilation in the vasculature surrounding the site of long-term brimonidine use for the treatment of rosacea.

Editorial 
Susan M. Cooper, MD, FRCP; Nina Madnani, MD, DVD; Lynnette Margesson, MD, FRCPC

In this issue, Lee and colleagues1 present the results of the largest prospective clinical cohort study to date concerning 507 women with vulvar lichen sclerosus (VLS). The authors present evidence that poor compliance with topical corticosteroid (TCS) treatment predisposes patients to the development of vulvar cancer and ...

Original Investigation  FREE
Andrew Lee, MBBS; Jennifer Bradford, MBBS; Gayle Fischer, MD

Importance  Adult vulvar lichen sclerosis (VLS) may be complicated by loss of vulvar structure and vulvar carcinoma. There is a lack of evidence as to the ideal method to maintain long-term remission and prevent complications.

Objectives  To determine whether long-term preventive topical corticosteroid (TCS) treatment of ...

Editorial: Reduced Risk of SCC With Adequate Treatment of Vulvar Lichen Sclerosus; Susan M. Cooper, MD, FRCP; Nina Madnani, MD, DVD; Lynnette Margesson, MD, FRCPC
Original Investigation  FREE
Neel Maria Helvind, MD; Lisbet Rosenkrantz Hölmich, MD, DMSc; Sigrun Smith, Bach San Scient Publ; Martin Glud, MD, PhD; Klaus Kaae Andersen, PhD; Susanne Oksbjerg Dalton, MD, PhD; Krzysztof Tadeusz Drzewiecki, MD, DMSc
Includes: Supplemental Content

Importance  In Denmark, the incidence of malignant melanoma (MM) has doubled during the past 25 years, with an incidence of 29.5 and 31.7 per 100 000 person-years in 2012 for men and women, respectively. Understanding the nature of this increase in incidence is important to optimize prevention, early ...

JAMA Dermatology Clinicopathological Challenge 
Samantha Gordon, BS; Jodi J. Speiser, MD; Lily Changchien Uihlein, MD
Research Letter 
Romi Bloom, BS; Kyle T. Amber, MD; Shasa Hu, MD; Robert Kirsner, MD, PhD

Whether there is an association between population inquisitiveness in skin cancer and melanoma incidence, mortality, and the mortality to incidence ratio is unknown. Google Trends quantifies interest in topics at the population level by analyzing all search queries for a specific term, thus serving as an increasingly useful ...

Observation 
Neetu Bhari, MD; Immaculata Xess, MD; Mragnayani Pandey, MSc; Sudheer Arava, MD; M. Ramam, MD

Primary cutaneous trichosporonosis in immunocompetent individuals is very rare.

Original Investigation  FREE
Rob Turrisi, PhD; Brittney Hultgren, MS; Kimberly A. Mallett, PhD; Mary Martini, MD; June K. Robinson, MD
Includes: Supplemental Content

Importance  Early detection of melanoma may improve survival. The present study continued research establishing that in-person training on skin self-examinations (SSEs) was significantly enhanced when delivered to patients with their partners present instead of to patients alone.

Objective  To examine 3 alternative SSE training approaches that ...

Original Investigation  FREE
Catherine M. Olsen, PhD; Bridie S. Thompson, PhD; Adèle C. Green, MBBS, PhD; Rachel E. Neale, PhD; David C. Whiteman, MBBS, PhD; for the QSkin Sun and Health Study Group
Includes: Supplemental Content

Importance  Primary prevention and early detection are integral strategies to reduce the burden of skin cancer.

Objectives  To describe the prevalence of sun protection and skin examination practices in a population exposed to high levels of ambient solar radiation and to identify associated factors.

Design, Setting, ...

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