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 Showing 1-20 of 75 Articles
Case Report/Case Series 
Rameez Kabani, BSc; Alain Brassard, MD, FRCPC

Importance  Complex regional pain syndrome (CRPS) is a chronic pain condition usually affecting the extremities. It mostly occurs in 3 distinct stages with intense pain being the hallmark feature in every stage. Skin abnormalities are common, and often necessary, in the clinical findings required to diagnose CRPS....

Matthias Scholz, MDSc; Susanne Buder, MD; Katrin Kerl, MD; Reinhard Dummer, MD; Claus Garbe, MD
Transepidermal melanocytic migration (TEM) is a histological feature that is frequently observed in malignant melanoma but may also occur in nevi (eg, Spitz nevi, acral nevi). Pagetoid TEM is considered a key indicator of malignant disease. We refer to an unusual case report by Kerl et al1 in a young ...
Topics: diagnosis
Rei Watanabe, MD, PhD; Jessica E. Teague, PhD; David C. Fisher, MD; Thomas S. Kupper, MD; Rachael A. Clark, MD, PhD
Includes: Supplemental Content
Low-dose alemtuzumab (LDA) therapy is highly effective and generally well tolerated for refractory cutaneous T-cell lymphoma (CTCL) with peripheral blood disease.1 Treatment with LDA is effective in patients with blood involvement (leukemic disease) but ineffective in mycosis fungoides (MF), reflecting the fact that these lymphomas derive from distinct T-cell subsets. ...
Ozan Haase, MD; Alexander J. von Thomsen, MD; Detlef Zillikens, MD; Werner Solbach, MD; Birgit Kahle, MD
Tuberculosis of the skin has become a rare disease in industrialized countries. Polymerase chain reaction (PCR) is a powerful diagnostic tool for mycobacterial infections of the skin, but it can fail, as demonstrated in this case.
JAMA Dermatology Clinicopathological Challenge 
Joshua A. Grosshandler, MD; Maria El-Charif, MD; H. Nicholas Shamma, MD
Chante Karimkhani, BA; Laura S. Huff, MD; Robert P. Dellavalle, MD, PhD, MSPH
Appearance-based interventions can have a positive impact on individual skin health and protection behaviors.1 The UV camera now provides 3-dimensional, multispectral imaging and analysis and has become an invaluable tool in dermatologic practices. Mounting evidence suggests that UV photography may be the most effective intervention to affect sun exposure behavior.1- ...
Case Report/Case Series 
Reuven Bergman, MD; Mariela Judith Nevet, MD, PhD; Hadas Gescheidt-Shoshany, MD; Allen L. Pimienta, BSc; Eyal Reinstein, MD, PhD

Importance  Marfan syndrome (MFS) is a dominantly inherited disorder of connective tissue caused by mutations in the fibrillin 1 gene (FBN1). The most common skin finding in MFS is striae distensae. Particular individuals referred for suspected MFS who do not completely fulfill the MFS diagnostic ...

Case Report/Case Series 
Gefei A. Zhu, BS; Uma Sundram, MD, PhD; Anne Lynn S. Chang, MD

Importance  Vismodegib is a Hedgehog signaling pathway inhibitor recently approved by the US Food and Drug Administration for advanced basal cell carcinoma. We present 2 cases of clinically significant squamous cell carcinoma within the tumor bed of locally advanced basal cell carcinoma found during vismodegib treatment.


Kenneth A. Katz, MD, MSc, MSCE; Erika E. Reid, MD; Mary-Margaret Chren, MD
Is drug sampling—when physicians give samples of prescription medicines provided by pharmaceutical companies to their patients—good or bad? Is the answer different for dermatologists than it is for other physicians?
Topics: dermatology
Ross J. Brothers, MS; Marla N. Jahnke, MD; Steven Daveluy, MD
A certain degree of earlobe drooping, known as earlobe ptosis, occurs with normal aging of the skin. We report the case of a woman with exaggerated earlobe ptosis due to habitually pulling the earlobes.
Simin Hellriegel, MD; Hans P. Bertsch, MD; Steffen Emmert, MD; Michael P. Schön, MD; Holger A. Haenssle, MD
JAMA Dermatology Clinicopathological Challenge 
Amanda L. Elam, MD; Patrick E. McCleskey, MD
Original Investigation 
Michael P. Hurley, MS; Randall S. Stafford, MD, PhD; Alfred T. Lane, MD, MA
Includes: Supplemental Content

Importance  Describing the relationship between the availability of free prescription drug samples and dermatologists’ prescribing patterns on a national scale can help inform policy guidelines on the use of free samples in a physician’s office.

Objectives  To investigate the relationships between free drug samples and dermatologists’ ...

Case Report/Case Series 
Lauren Strazzula, BA; Daniel S. Pratt, MD; Janet Zardas, NP; Raymond T. Chung, MD; Michael Thiim, MD; Daniela Kroshinsky, MD, MPH

Importance  Telaprevir, combined with pegylated interferon alfa and ribavirin, is an efficacious approach to treat hepatitis C virus infection. A morbilliform eruption associated with telaprevir is a common adverse effect experienced by patients. Current guidelines mandate telaprevir discontinuation in any patient with a severe, progressive, or unresponsive ...

Roberto A. Novoa, MD; Kord S. Honda, MD; Erica Campagnaro, MD; Meg R. Gerstenblith, MD
POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) is a paraneoplastic syndrome caused by plasma cell dyscrasias. We report hypertensive emergency and acral matlike telangiectasias as novel manifestations of POEMS syndrome (POEMS). Also, to our knowledge, this is the first reported case of calciphylaxis and POEMS occurring in ...
Toshifumi Takahashi, MD; Noriki Fujimoto, MD, PhD; Gen Nakanishi, MD, PhD; Norihisa Ishii, MD, PhD; Toshihiro Tanaka, MD, PhD
JAMA Dermatology Clinicopathological Challenge 
Daniel Zaghi, MD, MS; Allison Readinger, MD; Alan Menter, MD
Original Investigation 
Jillian Havey Swary, MD; Erik J. Stratman, MD

Importance  Curriculum and role modeling adjustments are necessary to address patient safety gaps occurring during dermatology residency.

Objective  To identify the source of clinical practices among dermatology residents that affect patient safety and determine the best approach for overcoming gaps in knowledge and practice patterns that ...

Original Investigation 
Weiyun Z. Ai, MD, PhD; Theresa H. Keegan, PhD, MS; David J. Press, MPhil; Juan Yang, PhD, MPH; Laura B. Pincus, MD; Youn H. Kim, MD; Ellen T. Chang, ScD

Importance  Mycosis fungoides and Sézary syndrome (MF/SS) are rare in children and young adults, and thus the incidence and outcomes in this patient population are not well studied.

Objective  To assess the incidence and outcomes of MF/SS in patients diagnosed before 30 years of age.

Design, ...

Case Report/Case Series 
Margaret I. Sanchez, MD; Harold S. Rabinovitz, MD; Margaret C. Oliviero, RNP; George W. Elgart, MD; Carmen Perez, MD; Susana Puig, MD; Josep Malvehy, MD; James M. Grichnik, MD, PhD
Includes: Supplemental Content

Importance  Mutations driving melanoma growth have diagnostic, prognostic, and therapeutic implications. Traditional classification systems do not correlate optimally with underlying melanoma growth–promoting mutations. Our objective was to determine whether unique dermoscopic growth patterns directly correlate with driving mutations.

Observations  We evaluated common driving mutations in 4 ...

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