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Case Report/Case Series 
Lauren Strazzula, BA; Daniel S. Pratt, MD; Janet Zardas, NP; Raymond T. Chung, MD; Michael Thiim, MD; Daniela Kroshinsky, MD, MPH

Importance  Telaprevir, combined with pegylated interferon alfa and ribavirin, is an efficacious approach to treat hepatitis C virus infection. A morbilliform eruption associated with telaprevir is a common adverse effect experienced by patients. Current guidelines mandate telaprevir discontinuation in any patient with a severe, progressive, or unresponsive ...

JAMA Dermatology Clinicopathological Challenge 
Daniel Zaghi, MD, MS; Allison Readinger, MD; Alan Menter, MD
Original Investigation 
Jillian Havey Swary, MD; Erik J. Stratman, MD

Importance  Curriculum and role modeling adjustments are necessary to address patient safety gaps occurring during dermatology residency.

Objective  To identify the source of clinical practices among dermatology residents that affect patient safety and determine the best approach for overcoming gaps in knowledge and practice patterns that ...

Original Investigation 
Weiyun Z. Ai, MD, PhD; Theresa H. Keegan, PhD, MS; David J. Press, MPhil; Juan Yang, PhD, MPH; Laura B. Pincus, MD; Youn H. Kim, MD; Ellen T. Chang, ScD

Importance  Mycosis fungoides and Sézary syndrome (MF/SS) are rare in children and young adults, and thus the incidence and outcomes in this patient population are not well studied.

Objective  To assess the incidence and outcomes of MF/SS in patients diagnosed before 30 years of age.

Design, ...

Roberto A. Novoa, MD; Kord S. Honda, MD; Erica Campagnaro, MD; Meg R. Gerstenblith, MD
POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) is a paraneoplastic syndrome caused by plasma cell dyscrasias. We report hypertensive emergency and acral matlike telangiectasias as novel manifestations of POEMS syndrome (POEMS). Also, to our knowledge, this is the first reported case of calciphylaxis and POEMS occurring in ...
Toshifumi Takahashi, MD; Noriki Fujimoto, MD, PhD; Gen Nakanishi, MD, PhD; Norihisa Ishii, MD, PhD; Toshihiro Tanaka, MD, PhD
Case Report/Case Series 
Margaret I. Sanchez, MD; Harold S. Rabinovitz, MD; Margaret C. Oliviero, RNP; George W. Elgart, MD; Carmen Perez, MD; Susana Puig, MD; Josep Malvehy, MD; James M. Grichnik, MD, PhD
Includes: Supplemental Content

Importance  Mutations driving melanoma growth have diagnostic, prognostic, and therapeutic implications. Traditional classification systems do not correlate optimally with underlying melanoma growth–promoting mutations. Our objective was to determine whether unique dermoscopic growth patterns directly correlate with driving mutations.

Observations  We evaluated common driving mutations in 4 ...

Case Report/Case Series 
Mark G. Kirchhof, MD, PhD; Agnes Y. Y. Lee, MD; Jan P. Dutz, MD

Importance  Biochemical markers of disease allow clinicians to monitor disease severity, progression, and response to treatment. C-reactive protein and erythrocyte sedimentation rate are commonly used biochemical markers of inflammatory disease. We present 2 cases that indicate that D-dimer levels may be useful as a potential biochemical marker ...

Case Report/Case Series 
Phil McClenahan, BSc; Lynlee L. Lin, BSc; Jean-Marie Tan, MB, BCh, BAO (hons); Ross Flewell-Smith, BCom, BEng; Helmut Schaider, MD; Kasturee Jagirdar, MSc; Victoria Atkinson, MBBS, FRACP; Duncan Lambie, BDSc, MBBS, FRCPA; Tarl W. Prow, BS, MSc, PhD; Richard A. Sturm, PhD; H. Peter Soyer, MD, FACD

Importance  Recent advances in targeting BRAFV600E mutations, which occur in roughly 50% of melanomas and 70% of benign nevi, have improved response rates and survival in patients with melanoma. With increased survival, the importance of other comorbidities increases and requires consideration in long-term management. This case ...

Research Letter 
Lauren Becker, MD; Wynnis L. Tom, MD; Karin Eshagh; Latanya T. Benjamin, MD; Amy S. Paller, MD
Includes: Supplemental Content
As for adult psoriasis, pediatric psoriasis has recently been associated with obesity, increased waist circumference percentiles, and waist-to-height ratios, and metabolic laboratory abnormalities1- 3 (eTable in Supplement). Although obesity could theoretically result from the functional limitations and psychosocial impact of psoriasis, adult females self-reported that obesity developed before psoriasis4 and ...
Jonathan I. Silverberg, MD, PhD, MPH
In this issue of JAMA Dermatology, Margolis et al1 report on the natural history of mild to moderate atopic dermatitis (AD) in children and adolescents. They examined data from the Pediatric Eczema Elective Registry (PEER), which is a prospective, 10-year observational registry that included 22 550 person-years of observation. The ...
Topics: eczema
Original Investigation 
Sarah Terras, MD; Thilo Gambichler, MD; Rose K. C. Moritz, MD; Markus Stücker, MD; Alexander Kreuter, MD

Importance  Topical corticosteroids are the current first-line therapy for vulvar lichen sclerosus (VLS). UV-A1 phototherapy may be a promising alternative treatment option, but controlled studies are lacking.

Objective  To compare the efficacy of high-potent topical corticosteroids with UV-A1 phototherapy in the treatment of VLS.

Design, Setting, ...

Original Investigation  FREE
Jacob S. Margolis; Katrina Abuabara, MD; Warren Bilker, PhD; Ole Hoffstad, MS; David J. Margolis, MD, PhD

Importance  Atopic dermatitis (AD) is a common illness of childhood.

Objective  To evaluate the natural history of AD and determine the persistence of symptoms over time.

Design, Setting, and Participants  A cross-sectional and cohort study of a nation-wide long-term registry of children with AD enrolled ...

Case Report/Case Series 
Mélanie Roriz, MD; Annabel Maruani, MD, PhD; Emmanuelle Le Bidre, MD; Marie-Christine Machet, MD; Laurent Machet, MD, PhD; Mahtab Samimi, MD

Importance  Pseudomonas aeruginosa–induced locoregional multiple nodular panniculitis without septicemia is an underreported condition, with only 3 cases reported to date. We report 3 new cases of P aeruginosa–induced multiple nodular panniculitis without septicemia and describe common features among all 6 cases, thus providing the first ...

Case Report/Case Series 
Dominique C. Pichard, MD; Alison M. Boyce, MD; Michael T. Collins, MD; Edward W. Cowen, MD, MHSc

Importance  The differential diagnosis for oral lentigines includes several syndromes with important associated systemic findings. McCune-Albright syndrome (MAS), a mosaic condition associated with café au lait pigmentation, is not typically considered a mucosal lentiginosis syndrome. The clinical phenotype of MAS is variable because of mosaicism, but oral ...

Original Investigation  FREE
Christopher W. Carr, MD; Emir Veledar, PhD; Suephy C. Chen, MD, MS

Importance  Chronic pruritus is a common problem with a deleterious effect on quality of life. The factors mediating the relationship between chronic pruritus and quality of life are poorly understood.

Objective  To determine the factors that mediate the impact of chronic pruritus on quality of life....

JAMA Dermatology Clinicopathological Challenge 
Jeannette Olazagasti, BS; Audrey S. Wang, MD; Rivkah Isseroff, MD
Topics: dermatology
Peter J. Hotez, MD, PhD; Rosannah M. Velasquez, BS; John E. Wolf Jr, MD
In 2005, the concept of a combination of essential medicines—the “rapid-impact” package—was proposed to simultaneously target 7 high-prevalence neglected tropical diseases (NTDs) in sub-Saharan Africa through programs of annual mass drug administration.1 The approach relied on the observation that the major NTDs affecting the poorest people in sub-Saharan Africa, led ...
Naoko Hasunuma, MD, PhD; Yoshihiro Umebayashi, MD, PhD; Motomu Manabe, MD, PhD
Leukonychia is divided into 2 major types: true leukonychia, which involves the nail plate, and apparent leukonychia, which involves the nail bed.1 Herein, we present the first case to our knowledge of true leukonychia successfully treated with selenium substitution.
Maider Pretel, MD, PhD; Mercedes Iñarrairaegui, MD, PhD; José Miguel Lera, MD; Leyre Aguado, MD, PhD; Miguel Angel Idoate, MD, PhD
Sorafenib (Nexavar; Bayer HealthCare AG) is an oral multikinase inhibitor approved by the US Food and Drug Administration for the treatment of unresectable hepatocellular carcinoma and advanced renal cell carcinoma. It inhibits multiple tyrosine kinases, including C-RAF and B-RAF, vascular endothelial growth factor receptors, and platelet-derived growth factor receptor (PDGFR). ...

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