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 Showing 1-20 of 96 Articles
Editorial  FREE
Victor Neel, MD, PhD
Wouldn’t it be great to have a device in your examination room to perform an “optical biopsy”? The human eye alone can get you just so far in dermatology. Even the finest morphologist often requires an invasive biopsy and histopathologic evaluation to arrive at a conclusive diagnosis. Apart from simple ...
Original Investigation  FREE
Mihaela Balu, PhD; Christopher B. Zachary, MD; Ronald M. Harris, MD; Tatiana B. Krasieva, PhD; Karsten König, PhD; Bruce J. Tromberg, PhD; Kristen M. Kelly, MD
Includes: Supplemental Content

Importance  Basal cell carcinomas (BCCs) are diagnosed by clinical evaluation, which can include dermoscopic evaluation, biopsy, and histopathologic examination. Recent translation of multiphoton microscopy (MPM) to clinical practice raises the possibility of noninvasive, label-free in vivo imaging of BCCs that could reduce the time from consultation to ...

Original Investigation 
Amélie Boespflug, MD; José Guerra, MD, MPH; Stéphane Dalle, MD, PhD; Luc Thomas, MD, PhD

Importance  Dermoscopy permits the detection of early-stage melanomas but is difficult to learn. It is important to develop effective teaching methods. Spaced education is a methodology within the field of adaptive learning that uses online tools to reinforce long-term retention.

Objectives  To determine whether a spaced ...

Case Report/Case Series 
Yong He, MD; Michiko Shimoda, PhD; Yoko Ono, MD; Itzel Bustos Villalobos, MD, PhD; Anupam Mitra, MD; Thomas Konia, MD; Sergei A. Grando, MD; John J. Zone, MD; Emanual Maverakis, MD

Importance  Immunobullous diseases mediated by IgA are often difficult to manage, but to date no mechanism has been proposed. Rituximab is an anti-CD20 monoclonal antibody that has demonstrated good efficacy in the treatment of refractory mucous membrane pemphigoid. However, not all cases of mucous membrane pemphigoid respond ...

Jennifer L. DePry, DO; Ritva Vyas, MBChB, FRACP; Hillard M. Lazarus, MD; Paolo F. Caimi, MD; Meg R. Gerstenblith, MD; Jeremy S. Bordeaux, MD, MPH

Importance  Hematopoietic cell transplantation has increased the survival of patients with several types of malignant hematologic disease and hematologic disorders; however, these patients have an increased risk of posttransplant cutaneous malignant neoplasms. Physicians should be aware of associated risk factors to provide appropriate patient screening and long-term ...

Research Letter 
Pedro Redondo, MD, PhD; Ana Gímenez de Azcarate, MD; Jorge M. Núñez-Córdoba, MD, MPH, PhD; Enrique J. Andreu, PhD; María García-Guzman, BSChem; Leyre Aguado, MD, PhD; Felipe Prosper, MD, PhD
This randomized clinical trial finds efficacy of cultured epidermal cell suspension and amniotic membrane–cultured epidermal cell grafting in treatment of vitiligo.
Mark A. Braswell, BS; Matthew W. Morrissey, MD; Simon A. Ritchie, MD; Robert L. Reddick, MD; Todd T. Kobayashi, MD
We present a case of vaccinia folliculitis that we term sycosis vaccinatum to correctly identify its etiology and scope of infection.
John M. Strasswimmer, MD, PhD
Basal cell carcinoma (BCC), when untreated, causes significant morbidity and mortality. Challenging tumors are regularly reviewed in multimodality tumor boards and are classified not by metastatic risk (inherently very low) but by histologic type and other tumor characteristics. Tumors are thus triaged appropriately to destruction, excision, topical therapy, Mohs surgery, ...
Original Investigation 
Trenton Custis, MD; April W. Armstrong, MD; Thomas H. King, MD; Victoria R. Sharon, MD, DTMH; Daniel B. Eisen, MD
Includes: Supplemental Content

Importance  Although applying adhesive strips to a wound closure has been shown to have outcomes equivalent to those with cuticular suturing, it is unknown whether adhesive strips provide additional benefit compared with dermal suturing alone.

Objective  To determine whether the addition of adhesive strips to a ...

Case Report/Case Series 
Erqi L. Pollom, MD; Timothy T. Bui, BS; Anne Lynn S. Chang, MD; A. Dimitrios Colevas, MD; Wendy Y. Hara, MD

Importance  Vismodegib is a targeted agent recently approved for treating patients who develop recurrent or locally advanced basal cell carcinoma (BCC), and will inevitably be integrated into existing therapy for advanced BCC as it becomes increasingly used. Improved understanding of how vismodegib interacts with other treatment modalities, ...

Editorial: Synergy of Irradiation With Vismodegib Treatment; John M. Strasswimmer, MD, PhD
Research Letter 
Peter R. Chai, MD, MMS; Roger Y. Wu, MD, MBA; Megan L. Ranney, MD, MPH; Jayne Bird, MD; Sandy Chai, MD; Brian Zink, MD; Paul S. Porter, MD, MBA
Emergency department (ED)–based teledermatology has become more common in recent years because patients who present to the ED with skin concerns often require prompt diagnosis and treatment. Skin concerns make up 3.3% of ED visits; most of these patients wait months to see a dermatologist.1 Recent studies have demonstrated the ...
Research Letter 
Tarun Narang, MD; Gitesh U. Sawatkar, MD; Muthu Sendhil Kumaran, MD; Sunil Dogra, MD, FRCP
Erythema nodosum leprosum (ENL) is an immune-mediated complication of leprosy, with an overall prevalence of 24% to 50%.1,2 In this pilot study, we evaluate the role of minocycline in recurrent and/or chronic ENL.
Mikio Ohtsuka, MD; Takako Miura, MD; Tatsuhiko Mori, MD; Masato Ishikawa, MD; Toshiyuki Yamamoto, MD
The immunoinhibitory receptor programmed death 1 (PD-1) is expressed on antigen-stimulated T cells. The interaction between PD-1 and its ligands, which are expressed on dendritic cells, macrophages, and cancer cells, inhibits antitumor activity of cytotoxic T cells.1 A fully human anti–PD-1 antibody, nivolumab, has been approved in Japan for unresectable ...
Joseph C. Pierson, MD; Laura K. Ferris, MD; Eleanor B. Schwarz, MD
This Viewpoint calls attention to the failure of the iPLEDGE program, which is intended to reduce fetal exposure to the teratogenic acne medication isotretinoin, and suggests ways to overhaul iPLEDGE.
Original Investigation 
Jason P. Lott, MD, MHS, MSHP; Deepak Narayan, MD; Pamela R. Soulos, MPH; Jenerius Aminawung, MD, MPH; Cary P. Gross, MD, MPH
Includes: Supplemental Content

Importance  Timely delivery of surgery for cancer affects health care quality and outcomes. However, population-based studies characterizing the delay of surgery for melanoma in the United States have not been performed.

Objective  To assess the delay of surgery for melanoma by tumor-, patient-, and physician-level characteristics....

Invited Commentary: Timely Surgical Follow-up for Melanoma Among Medicare Beneficiaries; Elaine Lin, BS; Jerry D. Brewer, MD
Invited Commentary 
Elaine Lin, BS; Jerry D. Brewer, MD
The incidence of melanoma is increasing worldwide and is rising faster than that of any other cancer in white individuals. Early detection of and treatment aids in identifying less advanced tumors plus prompt surgical treatment could alleviate stress and anxiety. The study by Lott et al1 in this issue of ...
Girish C. Mohan, BS; Peter A. Lio, MD

Importance  Atopic dermatitis (AD) is a common skin condition treated by dermatologists, allergists, pediatricians, and primary care physicians. Several treatment guidelines and therapeutic parameters exist for the management of this disease. Health care professionals may be unaware of guidelines created by specialty organizations other than their own....

JAMA Dermatology Clinicopathological Challenge 
Evan W. Piette, MD; Karolyn A. Wanat, MD; Douglas J. Pugliese, MD, MPH
This case study describes a woman with an ulcerated plaque on the forearm after a hospital admission for congestive heart failure. Histopathologic examination of a 4-mm punch biopsy specimen demonstrated marked superficial and deep inflammation composed predominantly of neutrophils with associated tissue necrosis. What is the diagnosis?
Research Letter 
Robert Denison Griffith, MD; Brian J. Simmons, BSc; Mohammad-Ali Yazdani Abyaneh, BSc; Fleta N. Bray, BSc; Leyre A. Falto-Aizpurua, MD; Keyvan Nouri, MD
The use of silver for medicinal purposes dates back to the eighth century ce and is still in use today.1- 3 Generalized argyria is characterized by slate-gray to blue discoloration of the skin caused by cutaneous deposits of silver particles after long-term ingestion of solutions containing colloidal silver ingredients or ...
Mustafa Abbass, MS; Firass Abiad, MD; Ossama Abbas, MD
Prurigo pigmentosa (PP) is a rare idiopathic inflammatory dermatosis that typically presents as pruritic erythematous papulovesicles in a reticular pattern predominantly on the trunk of young women.1- 3 The lesions then resolve with residual hyperpigmentation. The pathogenesis of PP is not completely clear. However, it has mainly been associated with ...

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