TY  - JOUR
T1  - Topical tretinoin for treatment of photodamaged skin: A multicenter study
AU  - Weinstein GD, Nigra TP, Pochi PE, et al
Y1  - 1991/05/01
N1  - 10.1001/archderm.1991.01680040067005
JO  - Archives of Dermatology
SP  - 659
EP  - 665
VL  - 127
IS  - 5
N2  - • The clinical and histologic effects of a new emollient cream formulation of topical tretinoin at concentrations of 0.05% and 0.01% were examined in 251 subjects with mild to moderate photodamaged facial skin in a randomized, doubleblind, vehicle-controlled, multicenter study. Seventy-nine percent of the subjects who received 0.05% tretinoin for 24 weeks showed overall improvement in photodamaged skin compared with improvement in 48% of the vehicle-treated control subjects. Significant reductions were found in fine wrinkling, mottled hyperpigmentation, roughness, and laxity after 0.05% tretinoin therapy when compared with controls. In addition, histologic changes of increased epidermal thickness, decreased melanin content, and stratum corneum compaction provide independent evidence supporting clinical improvement. Side effects of erythema, peeling, and stinging were usually mild and well tolerated.(Arch Dermatol. 1991;127:659-665)
SN  - 0003-987X
M3  - doi: 10.1001/archderm.1991.01680040067005
UR  - http://dx.doi.org/10.1001/archderm.1991.01680040067005
ER  -