TY  - JOUR
T1  - Sclerosing agents in the treatment of telangiectasia: Comparison of the clinical and histologic effects of intravascular polidocanol, sodium tetradecyl sulfate, and hypertonic saline in the dorsal rabbit ear vein model
AU  - Goldman MP, Kaplan RP, Oki LN, Cavender PA, Strick RA, Bennett RG
Y1  - 1987/09/01
N1  - 10.1001/archderm.1987.01660330107021
JO  - Archives of Dermatology
SP  - 1196
EP  - 1201
VL  - 123
IS  - 9
N2  - • A 0.25-mL quantity of 0.25%, 0.5%, and 1.0% polidocanol (Aethoxysclerol [France]), 0.5% sodium tetradecyl sulfate (Sotradecol Injection), and 23.4% hypertonic saline was injected into the dorsal marginal rabbit ear vein; clinical and histologic thrombosis resulted that lasted between four and eight days. The lowest concentration of polidocanol (0.25%) demonstrated immediate thrombosis; however, no clinical or histologic changes occurred eight days after injection. With all other agents, histologic fibrosis of the vessel correlating with clinical disappearance occurred after eight days. However, 0.5% polidocanol and sodium tetradecyl sulfate developed recanalization through the initially sclerosed vessel between eight and 14 days, with clinical reappearance of the 0.5% polidocanol-injected vessel at 30 days, after injection. Cutaneous necrosis was noted clinically and histologically in three of ten vessels injected with 1.0% polidocanol and in two of ten vessels injected with hypertonic saline. Clinical and histologic evidence of necrosis occurred with and without extravasation of the sclerosants.(Arch Dermatol 1987;123:1196-1201)
SN  - 0003-987X
M3  - doi: 10.1001/archderm.1987.01660330107021
UR  - http://dx.doi.org/10.1001/archderm.1987.01660330107021
ER  -