TY  - JOUR
T1  - Dapsone-induced motor polyneuropathy: A complication of prolonged treatment of subcorneal pustular dermatosis
AU  - Fredericks EJ, Kugelman TP, Kirsch N
Y1  - 1976/08/01
N1  - 10.1001/archderm.1976.01630320064020
JO  - Archives of Dermatology
SP  - 1158
EP  - 1160
VL  - 112
IS  - 8
N2  - • A motor polyneuropathy developed in a woman with subcorneal pustular dermatosis of 16 years' duration, who had received at least 300 gm of dapsone over a five-year period and 80 gm during the four-month period of progression of her neurologic symptoms. Although the patient believed her muscle power had returned to normal four months after the drug was stopped, a slight peripheral neuropathy remained. Electrodiagnostic and clinical features during the period of greatest weakness and the subsequent 16 months were consistent with a polyneuropathy of the axonal type. The neurotoxicity of dapsone appears to be dosedependent, but the mechanism by which it occurs is unknown.(Arch Dermatol 112:1158-1160, 1976)
SN  - 0003-987X
M3  - doi: 10.1001/archderm.1976.01630320064020
UR  - http://dx.doi.org/10.1001/archderm.1976.01630320064020
ER  -