TY  - JOUR
T1  - Allergic contact dermatitis due to ingredients of vehicles: A "vehicle tray" for patch testing
AU  - Fisher AA, Pascher F, Kanof NB
Y1  - 1971/09/01
N1  - 10.1001/archderm.1971.04000210060011
JO  - Archives of Dermatology
SP  - 286
EP  - 290
VL  - 104
IS  - 3
N2  - One hundred patients suspected of having allergic eczematous contact dermatitis due to topically administered medications were patch tested with a "vehicle tray" composed of 15 substances commonly found in vehicles of current preparations. Positive tests were obtained in 30 of 100 patients. There were 18 reactions to ethylenediamine; 6 to lanolin; 3 to parabens; 2 each to phenylmercuric acetate, thimerosal, dichlorophene, propylene glycol monostearate, and triethanolamine; 1 to sorbic acid for a total of 40 positive reactions. Vehicles play a significant role in producing sensitization and allergic contact dermatitis. The importance of testing with a standard concentration of each ingredient in preference to the total formulation is shown by the sizable incidence of false-negative reactions with the total formulation.
SN  - 0003-987X
M3  - doi: 10.1001/archderm.1971.04000210060011
UR  - http://dx.doi.org/10.1001/archderm.1971.04000210060011
ER  -