TY  - JOUR
T1  - PHarmacogenomics and dermatological therapeutics
AU  - Lowitt MH, Shear NH
Y1  - 2001/11/01
N1  - 10.1001/archderm.137.11.1512
JO  - Archives of Dermatology
SP  - 1512
EP  - 1514
VL  - 137
IS  - 11
N2  - 
Advances in the understanding of the structure and function of the human genome offer an opportunity to reexamine some old questions about the interplay between genetics and individual reactions to drugs. Pharmacogenetics examines questions related to individual variations in drug efficacy as well as drug toxicity. Why is it that a drug affects one individual in one way, while it may lead to a more blunted or a more dramatic therapeutic effect in another individual, or cause a serious untoward reaction in another? Why is it that the same drug can affect a person in one way on one occasion, but in a different way at another point in time? Although exogenous factors such as concomitant viral infection and multiple drug interactions may account for some variation in drug response, genetic variability in drug metabolism, drug clearance, or end-organ effect, accounts for much of the variation that previously was considered to be "idiopathic."1- 2

SN  - 0003-987X
M3  - doi: 10.1001/archderm.137.11.1512
UR  - http://dx.doi.org/10.1001/archderm.137.11.1512
ER  -