TY  - JOUR
T1  - HIgh association of human herpesvirus 8 in large-plaque parapsoriasis and mycosis fungoides
AU  - Kreuter A, Bischoff S, Skrygan M, et al
Y1  - 2008/08/01
N1  - 10.1001/archderm.144.8.1011
JO  - Archives of Dermatology
SP  - 1011
EP  - 1016
VL  - 144
IS  - 8
N2  - Objective 
    To investigate the presence of human herpesvirus 8 (HHV-8) in lesional skin of German patients with large-plaque parapsoriasis (LPP) or mycosis fungoides (MF). The pathogenetic relevance of HHV-8 in cutaneous T-cell lymphoma is controversial. Recently, a highly significant association of HHV-8 in LPP was found, which suggests a role in the pathogenesis of this disease.Design 
    Retrospective study of the presence of HHV-8 in German patients with lymphoproliferative diseases.Setting 
    Dermatologic clinic at a university hospital of the Ruhr University Bochum, Bochum, Germany.Patients 
    Fifty-three patients treated for lymphoproliferative skin diseases were included in the study, including 14 patients with LPP, 31 with different stages of MF, and 8 with lymphomatoid papulosis (LyP). Twenty-three patients with Kaposi sarcoma (KS) made up the positive control group, and 10 patients with atopic dermatitis served as negative controls.Main Outcome Measures 
    The presence of HHV-8 was analyzed from paraffin-embedded lesional tissue samples using a nested polymerase chain reaction for the open reading frame (ORF) 26 and with immunohistochemical staining for the latency-associated nuclear antigen (LANA) encoded by ORF 73.Results 
    A high association of HHV-8 infection in both lymphoproliferative skin diseases was observed: 87% of LPP and 70% of MF tissue samples tested positive for HHV-8 DNA from ORF 26. However, HHV-8 was not detectable in LPP and MF by using the immunohistochemical marker LANA.Conclusions 
    A virus unambiguously associated with KS, HHV-8 was frequently detected at low amounts in LPP and MF specimens. However, based on the methods of HHV-8 detection used in this study, no conclusion can be drawn on the etiologic and pathogenetic role of HHV-8 in these diseases.
SN  - 0003-987X
M3  - doi: 10.1001/archderm.144.8.1011
UR  - http://dx.doi.org/10.1001/archderm.144.8.1011
ER  -