TY - JOUR T1 - INfliximab-induced lupus erythematosus tumidus in a patient with rheumatoid arthritis AU - Schneider SW, Staender S, Schlüter B, Luger TA, Bonsmann G Y1 - 2006/01/01 N1 - 10.1001/archderm.142.1.115 JO - Archives of Dermatology SP - 109 EP - 116 VL - 142 IS - 1 N2 - Infliximab is a chimeric mouse-human monoclonal antibody targeting tumor necrosis factor α. It is approved for the treatment of refractory rheumatoid arthritis (RA), Crohn disease, ankylosing spondylitis, and psoriatic arthritis. Infliximab usually is well tolerated and has a good safety profile; only rare cases of severe adverse effects, including cardiac failure or mycobacterial infections, have been reported.1 A frequently observed and striking laboratory finding is the development of antinuclear antibodies, usually without clinical lupuslike symptoms.2 SN - 0003-987X M3 - doi: 10.1001/archderm.142.1.115 UR - http://dx.doi.org/10.1001/archderm.142.1.115 ER -