TY  - JOUR
T1  - Dyslipidemia in granuloma annulare: A case-control study
AU  - Wu W, Robinson-Bostom L, Kokkotou E, Jung H, Kroumpouzos G
Y1  - 2012/10/01
N1  - 10.1001/archdermatol.2012.1381
JO  - Archives of Dermatology
SP  - 1131
EP  - 1136
VL  - 148
IS  - 10
N2  - Objectives 
                  To estimate the prevalence of dyslipidemia (DLP) among individuals with idiopathic granuloma annulare and to examine associations with disease characteristics and comorbidities, such as metabolic syndrome.Design 
                  Case-control study using review of medical records from January 2002 through December 2010.Setting 
                  A university hospital and a health care system.Participants 
                  Adults consisting of 140 patients and 420 individuals serving as controls matched for age, sex, race/ethnicity, hypertension, type 2 diabetes mellitus, and hypothyroidism.Main Outcome Measures 
                  Prevalence of DLP and its associated components (hypercholesterolemia, hypertriglyceridemia, elevated low-density lipoprotein cholesterol, and low high-density lipoprotein cholesterol) in idiopathic granuloma annulare, as well as odds ratio of DLP after adjusting for confounding variables.Results 
                  The prevalence of DLP was 79.3% among granuloma annulare cases and 51.9% among controls (P < .001). Granuloma annulare was associated with DLP (odds ratio, 4.04; 95% CI, 2.53-6.46) after adjusting for confounding variables. Statistically significant differences between patient and control groups were found for levels of total cholesterol, triglycerides, and low-density lipoprotein cholesterol (P < .001 for all variables). A statistically significant association between the extent of disease and DLP (P = .02) was shown. Annular lesion morphology was associated with hypercholesterolemia (P = .02) and DLP (P = .01).Conclusions 
                  This study indicates an association between granuloma annulare and DLP. Dyslipidemia is more common in generalized than in localized/disseminated disease, and the annular lesion morphology is associated with hypercholesterolemia and DLP. Physicians should be aware of these important associations and consider them in the management of granuloma annulare.
SN  - 0003-987X
M3  - doi: 10.1001/archdermatol.2012.1381
UR  - http://dx.doi.org/10.1001/archdermatol.2012.1381
ER  -