TY  - JOUR
T1  - Acquired epidermodysplasia verruciformis syndrome in hiv-infected pediatric patients: Prospective treatment trial with topical glycolic acid and human papillomavirus genotype characterization
AU  - Moore RL, de Schaetzen V, Joseph M, et al
Y1  - 2012/01/01
N1  - 10.1001/archdermatol.2011.268
JO  - Archives of Dermatology
SP  - 128
EP  - 130
VL  - 148
IS  - 1
N2  - 
Many children with human immunodeficiency virus (HIV) also have diffuse flat warts, which occur primarily on the face and dorsal surface of the hands and are often recalcitrant to multiple treatments. Alpha-hydroxy acids have demonstrated some effectiveness in the treatment of flat warts.1 Flat warts in the general population are usually caused by infection with human papillomavirus (HPV) types 3 and 10.2 However, flat warts in epidermodysplasia verruciformis (EV), a rare genodermatosis associated with a profound susceptibility to HPV infection, are caused by EV-HPV types 5, 8, 9, 12, 14, 15, 17, 19 through 25, and 96.3- 4 Acquired EV-like clinical disease has been described in immunosuppressed patients, including patients with HIV,4 but it is unknown if EV-HPV types cause flat warts in this setting. We sought to characterize HPV types and evaluate the efficacy, safety, and tolerability of glycolic acid, 15%, lotion for treatment of flat warts in HIV-positive children.

SN  - 0003-987X
M3  - doi: 10.1001/archdermatol.2011.268
UR  - http://dx.doi.org/10.1001/archdermatol.2011.268
ER  -