RT Journal
A1 Brown RJ, Rother KI, Artman H, et al
T1 MInocycline-induced drug hypersensitivity syndrome followed by multiple autoimmune sequelae
JF Archives of Dermatology
JO Archives of Dermatology
YR 2009
FD January 1
VO 145
IS 1
SP 63
OP 66
DO 10.1001/archdermatol.2008.521
UL http://dx.doi.org/10.1001/archdermatol.2008.521
AB Background 
    Drug hypersensitivity syndrome (DHS) is a severe, multisystem adverse drug reaction that may occur following the use of numerous medications, including anticonvulsants, sulfonamides, and minocycline hydrochloride. Long-term autoimmune sequelae of DHS have been reported, including hypothyroidism.Observations 
    A 15-year-old female adolescent developed DHS 4 weeks after starting minocycline therapy for acne vulgaris. Seven weeks later she developed autoimmune hyperthyroidism (Graves disease), and 7 months after discontinuing minocycline therapy she developed autoimmune type 1 diabetes mellitus. In addition, she developed elevated titers of several markers of systemic autoimmune disease, including antinuclear, anti-Sjögren syndrome A, and anti-Smith antibodies.Conclusions 
    Minocycline-associated DHS may be associated with multiple autoimmune sequelae, including thyroid disease, type 1 diabetes mellitus, and elevated markers of systemic autoimmunity. Long-term follow-up is needed in patients with DHS to determine the natural history of DHS-associated sequelae.