RT Journal
A1 Schilling LM, Dellavalle RP
T1 DEaling with unanticipated mortality in a large randomized clinical trial of topical tretinoin
JF Archives of Dermatology
JO Archives of Dermatology
YR 2009
FD January 1
VO 145
IS 1
SP 76
OP 76
DO 10.1001/archdermatol.2008.520
UL http://dx.doi.org/10.1001/archdermatol.2008.520
AB 
Millions of people have used topical tretinoin to treat acne and photoaging.2- 4 In this issue, Weinstock et al5 report an unexpected result that led to the premature halt of their randomized, placebo-controlled Department of Veterans Affairs Topical Tretinoin Chemoprevention (VATTC) trial designed to determine whether topical tretinoin, 0.1%, cream prevents basal and squamous cell skin cancer in US veterans. Limited topical tretinoin use (up to twice daily to the face and ears) was associated with increased death (end-of-intervention hazard ratio, 1.54; P = .01).