RT Journal
A1 Trimble JW, Mendelson DS, Fetter BF, Ingram P, Gallagher JJ, Shelburne JD
T1 CUtaneous pigmentation secondary to amiodarone therapy
JF Archives of Dermatology
JO Archives of Dermatology
YR 1983
FD November 1
VO 119
IS 11
SP 914
OP 918
DO 10.1001/archderm.1983.01650350042012
UL http://dx.doi.org/10.1001/archderm.1983.01650350042012
AB • Amiodarone (Cordarone) is an iodinated cardiac antiarrhythmic drug that causes a slate-gray discoloration of the sun-exposed skin and a yellow-brown stippling of the cornea. Histopathologically, biopsy specimens of aminodarone pigmentation sites disclose yellow-brown refractile granules in the reticular dermis. These granules were characterized by transmission electron microscopy as being concentrically arranged intralysosomal inclusions ("myelinlike" bodies) in dermal endothelial cells and perivascular smooth-muscle cells. Electron probe x-ray analysis of these same inclusions disclosed definite peaks for iodine, evidence for the presence of amiodarone or a metabolite of the drug at these sites. Amiodarone, then, concentrates in lysosomes and causes an accumulation of lipids similar to what has been seen with other cationic amphiphilic compounds, such as the glycosphingolipid stored in Fabry's disease. Amiodarone must be recognized as a cause of a drug-induced lipid storage disease with cutaneous and corneal manifestations.(Arch Dermatol 1983;119:914-918)