RT Journal
A1 Rasmussen JE
T1 LIndane toxicity
JF Archives of Dermatology
JO Archives of Dermatology
YR 1980
FD November 1
VO 116
IS 11
SP 1226
OP 1226
DO 10.1001/archderm.1980.01640350016002
UL http://dx.doi.org/10.1001/archderm.1980.01640350016002
AB To the Editor.— 
    Pramanik and Hansen1 have presented an unusual case of an ill infant (who was premature, had a ventriculoseptal defect, pneumonia, congestive heart failure, and marasmus) with scabies. After treatment with crotamiton failed, the patient was treated liberally with lindane, followed by "increased muscle tone, poor orientation to a visual animate stimulus, and frequent side-to-side head movements." Forty-six hours after lindane treatment, the level of lindane was 0.10 μg/mL, 17 times the mean 48-hour posttherapy results reported by Ginsburg et al.2 Pramanik and Hansen stress that rats on proteindeficient diets are also more sensitive to lindane. Decreased fat depots were no longer available to store the percutaneously absorbed lindane, which therefore exposed the CNS to toxic levels.They condluded that "case 1 raises the question of whether 1% gamma benzene hexachloride can be safely applied topically even once to small infants" and suggest sulfur, crotami