RT Journal
A1 Millikan LE, Harrell E
T1 DRug reactions to the sulfones
JF Archives of Dermatology
JO Archives of Dermatology
YR 1970
FD August 1
VO 102
IS 2
SP 220
OP 224
DO 10.1001/archderm.1970.04000080092020
UL http://dx.doi.org/10.1001/archderm.1970.04000080092020
AB In a brief temporal span, two patients treated with diaminodiphenyl sulfone had significant reactions to the drug. These were severe hemolysis and the hitherto undescribed reaction of cholestatic jaundice. Review of the literature in regards to indications for sulfone therapy and the drug-associated reactions was accomplished. A range of diseases from cystic acne to recurrent carcinoma of the cervix uteri are reported to respond beneficially to these drugs. Among the multifold reactions are included several cutaneous syndromes. The significance of these drug reactions to the practicing dermatologist is increasing, in view of the varied dermatologic indications for their use and the numerous cutaneous manifestations of intolerance to them.