RT Journal
A1 Wile UJ
T1 DEtroit dermatological society
JF Archives of Dermatology and Syphilology
JO Archives of Dermatology and Syphilology
YR 1925
FD December 1
VO 12
IS 6
SP 915
OP 919
DO 10.1001/archderm.1925.02370120145015
UL http://dx.doi.org/10.1001/archderm.1925.02370120145015
AB Ichthyosis Hystrix. Presented by Dr. Wile. 
    M. S., a schoolgirl, aged 12, said that the skin condition had been present since birth; it was asymptomatic and not progressive. There was a generalized, dry, noninflammatory scaling of the skin, the scales being closely adherent over the extremities. The entire trunk, and especially the neck and axillae, presented some hyperpigmentation, which was definitely linear over the abdomen. There were minute, pinhead-sized, papillary excrescences about the neck, axillae and abdomen, and the histologic picture was that of a papillomatous hyperplasia with hyperkeratosis. No active chromatophores were found.Acanthosis Nigricans, Juvenile Type. Presented by Dr. Wile. 
    L. S., a schoolgirl, aged 14, in 1920 first noticed an increase in pigmentation about the neck, axillae and other normally pigmented areas. This condition had progressed and become generalized, varying from brown to black, and being especially pronounced in the flexures, about the nipples and the external