RT Journal
A1 Wu W, Robinson-Bostom L, Kokkotou E, Jung H, Kroumpouzos G
T1 Dyslipidemia in granuloma annulare: A case-control study
JF Archives of Dermatology
JO Archives of Dermatology
YR 2012
FD October 1
VO 148
IS 10
SP 1131
OP 1136
DO 10.1001/archdermatol.2012.1381
UL http://dx.doi.org/10.1001/archdermatol.2012.1381
AB Objectives 
                  To estimate the prevalence of dyslipidemia (DLP) among individuals with idiopathic granuloma annulare and to examine associations with disease characteristics and comorbidities, such as metabolic syndrome.Design 
                  Case-control study using review of medical records from January 2002 through December 2010.Setting 
                  A university hospital and a health care system.Participants 
                  Adults consisting of 140 patients and 420 individuals serving as controls matched for age, sex, race/ethnicity, hypertension, type 2 diabetes mellitus, and hypothyroidism.Main Outcome Measures 
                  Prevalence of DLP and its associated components (hypercholesterolemia, hypertriglyceridemia, elevated low-density lipoprotein cholesterol, and low high-density lipoprotein cholesterol) in idiopathic granuloma annulare, as well as odds ratio of DLP after adjusting for confounding variables.Results 
                  The prevalence of DLP was 79.3% among granuloma annulare cases and 51.9% among controls (P < .001). Granuloma annulare was associated with DLP (odds ratio, 4.04; 95% CI, 2.53-6.46) after adjusting for confounding variables. Statistically significant differences between patient and control groups were found for levels of total cholesterol, triglycerides, and low-density lipoprotein cholesterol (P < .001 for all variables). A statistically significant association between the extent of disease and DLP (P = .02) was shown. Annular lesion morphology was associated with hypercholesterolemia (P = .02) and DLP (P = .01).Conclusions 
                  This study indicates an association between granuloma annulare and DLP. Dyslipidemia is more common in generalized than in localized/disseminated disease, and the annular lesion morphology is associated with hypercholesterolemia and DLP. Physicians should be aware of these important associations and consider them in the management of granuloma annulare.