RT Journal
A1 Hyde MA, Hadley ML, Tristani-Firouzi P, Goldgar D, Bowen GM
T1 A randomized trial of the off-label use of imiquimod, 5%, cream with vs without tazarotene, 0.1%, gel for the treatment of lentigo maligna, followed by conservative staged excisions
JF Archives of Dermatology
JO Archives of Dermatology
YR 2012
FD May 1
VO 148
IS 5
SP 592
OP 596
DO 10.1001/archdermatol.2012.270
UL http://dx.doi.org/10.1001/archdermatol.2012.270
AB Objective 
                  To determine if the complete response rates of lentigo maligna (LM) to imiquimod, 5%, cream can be improved by the addition of a topical retinoid.Design 
                  Prospective randomized study of patients treated with imiquimod alone vs imiquimod plus a topical retinoid, followed by conservative staged excisions.Setting 
                  Mohs surgical clinic in an academic institution.Patients 
                  Ninety patients with biopsy-confirmed LM.Interventions 
                  Ninety patients with 91 LMs were randomized into 2 groups. One group received imiquimod, 5%, cream 5 d/wk for 3 months, while the other group also received tazarotene, 0.1%, gel 2 d/wk for 3 months. Following topical therapy, all patients underwent staged excisions and frozen section analysis with Melan-A immunostaining to confirm negative margins.Main Outcome Measure 
                  The presence or absence of residual LM at the time of staged excision.Results 
                  Forty-six patients with 47 LMs were randomized to receive monotherapy: 42 of 47 LMs reached the intended treatment duration, with 27 complete responses (64%). Forty-four patients with 44 LMs were randomized to receive combined therapy: 37 of 44 LMs reached the intended treatment duration, with 29 complete responses (78%). This difference did not reach statistical significance (P = .17). There have been no recurrences to date, with a mean follow-up period of 42 months.Conclusions 
                  Among patients who received topical imiquimod with vs without tazarotene, 22% (8 of 37) of lesions vs 36% (15 of 42) of lesions showed residual LM on staged excisions. Pretreating LM with imiquimod, 5%, cream may decrease surgical defect sizes; however, total reliance on topical imiquimod as an alternative to surgery may put the patient at increased risk of a local recurrence.Trial Registration 
                  clinicaltrials.gov Identifier: NCT00707174