RT Journal
A1 Schleichert RA, Seliger SL, Zhan M, Gaspari AA
T1 NEphrogenic systemic fibrosis and diabetes mellitus
JF Archives of Dermatology
JO Archives of Dermatology
YR 2012
FD February 1
VO 148
IS 2
SP 255
OP 257
DO 10.1001/archdermatol.2011.1268
UL http://dx.doi.org/10.1001/archdermatol.2011.1268
AB 
Over the past decade, specialists in all areas of medicine have become increasingly aware of and interested in nephrogenic systemic fibrosis (NSF), yet much of this devastating disease's pathogeny remains a mystery. Many risk factors have been implicated, including liver disease,1 erythropoietin,2 proinflammatory and hypercoagulable conditions, dialysis, and gadolinium exposure.3 Diabetes mellitus (DM) and renal failure are both associated with fibrosing disorders. While a strong association exists between kidney disease and NSF, diabetes has never before been proposed as a risk factor. The most common cause of renal failure in the United States is DM.4- 5 Seven percent of the population has diabetes, and every third patient with DM develops nephropathy, accounting for about 45% of end-stage renal disease (ESRD).4 Herein, we review 295 cases of NSF to determine if diabetes could be a risk factor for NSF development.