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June 1968, Vol 97, No. 6 >
Article | June 1968

The Role of Immunologic Aberrations in the Pathogenesis of Lymphoma: Title and subTitle BreakWith Particular Reference to Mycosis Fungoides and Exfoliative Erythroderma

Stanley M. Bierman, MD
[+] Author Affiliations

Accepted for publication Jan 8, 1968.

Reprint requests to 1100 Glendon Ave, Los Angeles, 90024 (Dr. Bierman).


Los Angeles

From the Department of Medicine, Division of Dermatology, University of California, Los Angeles Medical Center and the divisions of dermatology, Wadsworth General and Long Beach Veterans hospitals.


Arch Dermatol. 1968;97(6):699-711. doi:10.1001/archderm.1968.01610120089014
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Comments

AUNITARIAN theory of the pathogenesis of malignant lymphoma seems improbable considering the multiplicity of morphologic types, histopathologic distinctions and variable clinical courses suggesting that there are multiple etiologic determinants of lymphoid malignancies. The induction of lymphoma in mice by oncogenic viruses1-4 and chemical carcinogens,5-8 epidemiologic9 and hereditary influences10-12 in Hodgkin's disease, the development of lymphomas as a consequence of the administration of anticonvulsant drugs13 and exposure to x-radiation,14,15 and studies of Burkitt's lymphoma16 all bespeak a great diversity of inductive influences. During the past decade persuasive insight into the pathogenesis of lymphoid malignancies has been advanced by the revelation that immunologic aberrations predispose to, are inductive, or are important associated features of malignant lymphoproliferative disease. The purpose of this paper is to review the experimental studies and clinical research relevant to the determinant role of abnormalities of immune mechanisms in the pathogenesis

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Gross, L.: Oncogenic Viruses , New York: Pergamon Press, 1961;.
2 +
Law, L.W.:  Studies of Thymic Function With Emphasis on the Role of the Thymus in Oncogenesis , Cancer Res 26:551, 1966;.
3 +
Rauscher, F.J.; Carrese, L.M.; and Baker, C.G.:  Survey of Viral Oncology With Particular Reference to Lymphoma , Cancer Res 26:1176, 1966;.
4 +
Stanley, N.F., et al:  The Association of Murine Lymphoma With Reovirus Type 3 Infections , Proc Soc Exp Biol 121:90, 1966;.
5 +
Berenbaum, M.C.:  Effect of Carcinogen on Immune Mechanisms , Brit Med Bull 20:159, 1964;.
6 +
 British Medical Bulletin: Mechanism of Carcinogenesis: Chemical , Physical and Viral , vol 20 (No. (2) ) 1964;.
7 +
Fiore-Donati, L., et al:  Induction of Malignant Lymphoma by Urethane in Adult Mice Bearing Syngeneic Thymic Grafts , Nature 208:398, 1965;.
8 +
Pietra, G.; Spencer, K.; and Shubek, P.:  Response of Newly Born Mice to a Chemical Carcinogen , Nature 183:1689, 1963;.
9 +
McMahon, B.:  Epidemiology in Hodgkin's Disease , Cancer Res 26:1189, 1966;.
10 +
Luden, F., et al:  Temporal Relationship of Leukemia and Lymphoma in Neighborhoods , J Nat Cancer Inst 37:123, 1966;.
11 +
Razes, D.V.; Diamond, H.D.; and Carver, L.F.:  Familial Hodgkin's Disease: Its Significance and Implications , Ann Intern Med 51:933, 1959;.
12 +
Reigby, P.G., et al:  Leukemia and Lymphoma , JAMA 197:25-30 ( (July 4) ) 1966;.
13 +
Hyman, G.A., et al:  The Development of Hodgkin's Disease and Lymphoma During Anticonvulsant Therapy , Blood 28:416, 1966;.
14 +
Anderson, R.E., and Ishida, K.:  Malignant Lymphoma in Survivors of the Atomic Bomb in Hiroshima , Ann Intern Med 61:853, 1964;.
15 +
Lamerton, L.F.:  Radiation Carcinogenesis , Brit Med Bull 20:134, 1964;.
16 +
Burkitt, H.D., and O'Conner, G.T.:  Malignant Lymphoma in African Children: A Clinical Syndrome , Cancer 14:258, 1961;.
17 +
Aisenberg, A.C.:  Studies in Delayed Hypersensitivity in Hodgkin's Disease , J Clin Invest 41:1964, 1962;.
18 +
Aisenberg, A.C., and Leskowitz, A.:  Antibody Formation in Hodgkin's Disease , New Eng J Med 268:1269, 1963;.
19 +
Aisenberg, A.C.:  Hodgkin's Disease: Diagnosis, Prognosis, Etiology and Immunologic Considerations , New Eng J Med 270:508, 565, 617, 1964;.
20 +
Aisenberg, A.C.:  Immunologic Aspects of Hodgkin's Disease , Medicine 43:189, 1964;.
21 +
Aisenberg, A.C.:  Manifestations of Immune Unresponsiveness in Hodgkin's Disease , Cancer Res 26:1189, 1966;.
22 +
Chase, M.:  Delayed-Type Hypersensitivity and the Immunology of Hodgkin's Disease With a Parallel Example of Sarcoidosis , Cancer Res 26:1077, 1966;.
23 +
Good, R.A., et al:  Immune Deficiency Diseases , Progr Allerg 6:187, 1962;.
24 +
Brown, R.S., et al:  Hodgkin's Disease: Immunologic, Clinical and Histologic Features of 50 Untreated Patients , Ann Intern Med 67:291, 1967;.
25 +
Hersch, E., and Oppenheim, J.J.:  Impaired "In Vitro" Lymphocyte Transfer in Hodgkin's Disease , New Eng J Med 273:1106, 1965;.
26 +
Fazio, M., and Calciata, A.:  Transfer of Antibody of Delayed Tuberculin Type in Lymphogranuloma , Panminerva Med 4:164, 1962;.
27 +
Muftuoglu, A., and Balkuv, S.:  Passive Transfer of Tuberculin Sensitivity to Patients With Hodgkin's Disease , New Eng J Med 277:126, 1967;.
28 +
Sheagren, J.N.; Block, J.B.; and Wolf, S.M.:  Reticuloendothelial System Phagocytic Function in Patients With Hodgkin's Disease , J Clin Invest 46:855, 1967;.
29 +
Blaylock, W., et al:  Normal Immunologic Reaction in Patients With the Lymphoma, Mycosis Fungoides , Cancer 19:233, 1966;.
30 +
Blaylock, W.; Oppenheim, J.; and Malmgren, R.:  Immunologic Studies of Mycosis Fungoides , J Invest Derm 46:28, 1966;.
31 +
Clendenning, W.E., and van Scott, E.J.:  Skin Autografts and Homografts in Patients With the Lymphoma Mycosis Fungoides , Cancer Res 25:1844, 1965;.
32 +
Waldorf, D.S.; Hynes, H.A.; and van Scott, E.J.:  Cutaneous Hypersensitivity and Desensitization in Patients With Mycosis Fungoides Lymphoma , Ann Intern Med 67:282, 1967;.
33 +
Rivers, M., and Horsfall, F L.: Virus and Rickettsial Infections of Man , ed, Philadelphia: J. B. Lippincott, 1959;, p 742.
34 +
Burchenal, J.H.:  Summary of Informal Discussion on: Immunology of Hodgkin's Disease , Cancer Res 26:1170, 1966;.
35 +
Citron, K.M., and Scadding, J.G.:  The Effect of Cortisone Upon the Reaction of the Skin to Tuberculin in Tuberculosis and Sarcoidosis , Quart J Med 26:277, 1957;.
36 +
Urbach, F.; Sones, M.; and Israel, H.L.:  Passive Transfer of Tuberculin Sensitivity in Patients With Sarcoidosis , New Eng J Med 247:794, 1952;.
37 +
Atwood, W.G.; Miller, R.C.; and Nelson, C.T.:  Sarcoidosis and the Malignant Lymphocytic Diseases , Arch Derm 94:144-151 ( (Aug) ) 1967;.
38 +
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39 +
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40 +
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41 +
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42 +
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43 +
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44 +
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45 +
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46 +
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47 +
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48 +
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49 +
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50 +
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51 +
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52 +
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53 +
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54 +
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55 +
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56 +
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57 +
Walford, R.L.:  Incidence of Lymphomas After Injection of Mice With Cells Differing at Weak Histocompatible Loci , Science 152:78, 1966;.
58 +
Joske, R.A., et al:  Murine Infection With Reovirus: IV. Late Chronic Disease and the Induction of Lymphoma After Reovirus 3 Infection , Brit J Exp Path 47:337, 1966;.
59 +
Kadowaki, J., et al:  XX/XY Lymphoid Chimerism in Congenital Immunologic Deficiency Disease With Thymic Alymphoplasia , Lancet 2:1152, 1965;.
60 +
Mathe, G.; Amiel, J.L.; and Schwarzenberg, L.:  Treatment of Total Body Irradiation in Man , NY Acad Sci 114:368, 1964;.
61 +
Schwarzenberg, L., et al:  White Blood Cell Transfusions , Israel J Med Sci 1:925, 1965;.
62 +
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63 +
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64 +
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65 +
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66 +
McIntire, K.R.; Sell, S.; and Miller, J.:  Pathogenesis of Post-Neonatal Thymectomy Wasting Syndrome , Nature 204:151, 1964;.
67 +
Good, R.A., et al:  The Role of the Thymus and Bursa of Fabricius in the Development of Effective Immune Mechanisms , NY Acad Sci 129:130, 1966;.
68 +
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70 +
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71 +
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72 +
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73 +
Law, L.W., and Potter, M.:  The Behavior of Transplants of Lymphoid Neoplasms in Irradiated Thymectomized Hybrid Mice , Proc Nat Acad Sci 42:160, 1956;.
74 +
Kunii, A., and Furth, J.:  Inhibition of Lymphoma Induction in Virus-Infected Rats by Thymectomy , Cancer Res 24:493, 1964;.
75 +
Dent, P.D., et al:  Chediak-Higashi Syndrome and Observations on the Nature of the Associated Malignancy , Lab Invest 15:1634, 1966;.
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77 +
Kough, R.H., Barnes, W.T.:  Thymoma in Association With Erythroid Aplasia, Bullous Skin Eruption and L.E. Phenomena, Report of a Case , Ann Intern Med 61:308, 1964;.
78 +
Maberry, J.D., and Stone, O.J.:  Kaposi's Sarcoma and Thymoma , Arch Derm 95:210-213 ( (Feb) ) 1967;.
79 +
Bierman, S.M., et al:  Farber's Disease: A Disorder of Mucopolysaccharide Metabolism With Articular, Respiratory and Neurologic Manifestations , Arthritis Rheum 9:620, 1966;.
80 +
Baer, R.L.; Bart, R.S.; and Michaelides, P.:  Exfoliative Erythroderma and Thymoma: Simultaneous Appearance of Unusual Generalized Dermatitis, "Universal" Candidiasis and Thymoma , Hautarzt 15:413, 1964;.
81 +
Bierman, S.M.:  Prelymphoma, Lymphoma and Pseudolymphoma Cutis , J Wadsworth Gen Hosp 9:113, 1966;.
82 +
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83 +
Krauss, S., and Sokal, J.E.:  Paraproteinemia in the Lymphomas , Amer J Med 40:400, 1966;.
84 +
Ranstrom, A.:  Malignant Lymphoma of the Thyroid and its Relationship to Hashimota's and Brill-Symmer's Disease , Acta Chir Scand 113:185, 1957;.
85 +
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86 +
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87 +
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89 +
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90 +
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91 +
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92 +
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93 +
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106 +
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120 +
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