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CLINICAL EXPERIENCE WITH ``POLYCIN,'' A POLYMYXIN-BACITRACIN OINTMENT

FRANK M. GASTINEAU, M.D.; H. J. FLORESTANO, Ph.D.
[+] Author Affiliations

``Polycin'' is a trade name of Pitman-Moore Company, Division of Allied Laboratories, Inc., Indianapolis 6.

Chairman, Department of Dermatology and Syphilology, Indiana University School of Medicine (Dr. Gastineau).


INDIANAPOLIS


Arch Dermatol. 1952;66(1):70-75. doi:10.1001/archderm.1952.01530260073007
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RECENT years have witnessed the advent of a number of new agents for local therapy in pyogenic infections of the skin. Certain of these, however, are not without disadvantages. Topical use of the sulfonamides and penicillin, while very effective, has resulted in sensitization in at least 5 and 10% of the cases, respectively,1 with indications that reactions to penicillin are increasing both in frequency and in severity. The use of nitrofurazone (furacin®) has likewise resulted in a significant degree of sensitization, reactions occurring in about 5% of the cases.2 Good results have been reported3 for dihydrostreptomycin in topical therapy, with sensitization manifested in 3.7% of patients treated. Prolonged use of this drug was not recommended, however, because of the rapid development of drug-fastness. The incidences of reactions obtained with the sulfonamides, penicillin, and dihydrostreptomycin thus become of importance, especially since these drugs are intended

REFERENCES

Miller, J. L.; Slatkin, M. H., and Johnson, B. A.:  Evaluation of Bacitracin in Local Treatment of Pyogenic Infections , Arch. Dermat. & Syph. 60:106 ( (July) ) 1949;.
Downing, J. G.; Hanson, M. C., and Lamb, M.:  Use of 5-Nitro-2-Furaldehyde Semicarbazone in Dermatology , J.A.M.A. 133:299 ( (Feb. 1) ) 1947;.
Downing, J. G., and Brecker, F. W.:  Further Studies in the Use of Furacin in Dermatology , New England J. Med. 239:862 ( (Dec. 2) ) 1948;.
Miller, J. L.; Slatkin, M. H.; Wechsler, H. L., and Johnson, B. A.:  Dihydrostreptomycin in Topical Therapy , Arch. Dermat. & Syph. 61:648 ( (April) ) 1950;.
Sulzberger, M. B., in discussion on Miller and others.3
Kile, R. L.; Welsh, A. L., and McAfee, G. D.:  Topical Use of Neomycin , Arch. Dermat. & Syph. 62:911 ( (Dec.) ) 1950;.
Hobby, G. L.; Lenert, T. F., and Dougherty, N.:  Newer Antibiotics: Factors Influencing Their Antimicrobial Activity , Ann. New York Acad. Sc. 53:27 ( (Aug. 30) ) 1950;.
Duncan, G. G.; Clancy, C. F.; Wolgamot, J. R., and Beidleman, B.:  Neomycin: Results of Clinical Use in 10 Cases , J. A. M. A. 145:75 ( (Jan. 13) ) 1951;.
Derzavis, J. L.; Rice, J. S., and Leland, L. S.:  Topical Bacitracin Therapy of Pyogenic Dermatoses , J. A. M. A. 141:191 ( (Sept. 17) ) 1949;.
Meleney, F. L., and Johnson, B. A.:  Bacitracin Therapy: The First 100 Cases of Surgical Infections Treated Locally with the Antibiotic , J. A. M. A. 133:675 ( (March 8) ) 1947;.
Johnson, B. A.; Anker, H., and Meleney, F. L.:  Bacitracin: A New Antibiotic Produced by a Member of the B. Subtilis Group , Science 102:376 ( (Oct. 12) ) 1945;.
Eagle, H.; Musselman, A. D., and Fleischman, R.:  The Action of Bacitracin and Subtilin on Treponema Pallidum in Vitro and in Vivo , J. Bact. 55:347 ( (March) ) 1948;.
Stansly, P. G.; Shepherd, R. G., and White, H. J.:  Polymyxin: A New Chemotherapeutic Agent , Bull. Johns Hopkins Hosp. 81:43 ( (July) ) 1947;.
Brownlee, G.:  Antibiotics Derived from Bacillus Polymyxa , Ann. New York Acad. Sc. 51:875 ( (June 22) ) 1949;.
Jones, T. S. G.:  Chemical Evidence for the Multiplicity of the Antibiotics Produced by Bacillus Polymyxa , Ann. New York Acad. Sc. 51:909 ( (June 22) ) 1949;.
Serri, F.:  Antifungal Activity of Aerosporin on Eight Species of Dermatomycetes , Compt. rend. Soc. biol. 143:362 ( (March 26) ) 1949;.
Schoenbach, E. B.; Bryer, M. S.; Bliss, E. A., and Long, P. H.:  Polymyxin: A Note on Experimental and Clinical Investigations , J. A. M. A. 136:1096 ( (April 24) ) 1948;.
Kagan, B. M.:  Influenzal Meningitis: Recovery of Case of 4 Weeks' Duration with Use of New Drug, Polymyxin B (Aerosporin) , Pediatrics 4:319 ( (Sept.) ) 1949;.
Ross, S.; Burke, F. G.; Rice, E. C.; Bischoff, H., and Washington, J. A.:  Treatment of Shigella Enteritis with Oral Streptomycin , J. A. M. A. 141:183 ( (Sept. 17) ) 1949;.
Kagan, B. M.; Krevsky, D.; Milzer, A., and Locke, M.:  Polymyxin B and Polymyxin E: Clinical and Laboratory Studies , J. Lab. & Clin. Med. 37:402 ( (March) ) 1951;.
Pulaski, E. J.; Baker, H. J.; Rosenberg, M. L., and Connell, J. F., Jr.:  Laboratory and Clinical Studies of Polymyxin B and E , J. Clin. Invest. 28:1028 ( (Sept.) ) 1949;.
Jeffries, S. F.; Nash, H. A.; Harmon, R. L.; Reynolds, D. C., and Bunde, C. A.:  A New Antibiotic Ointment Base , J. Am. Pharm. A. (Scient. Ed.), to be published.

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Miller, J. L.; Slatkin, M. H., and Johnson, B. A.:  Evaluation of Bacitracin in Local Treatment of Pyogenic Infections , Arch. Dermat. & Syph. 60:106 ( (July) ) 1949;.
Downing, J. G.; Hanson, M. C., and Lamb, M.:  Use of 5-Nitro-2-Furaldehyde Semicarbazone in Dermatology , J.A.M.A. 133:299 ( (Feb. 1) ) 1947;.
Downing, J. G., and Brecker, F. W.:  Further Studies in the Use of Furacin in Dermatology , New England J. Med. 239:862 ( (Dec. 2) ) 1948;.
Miller, J. L.; Slatkin, M. H.; Wechsler, H. L., and Johnson, B. A.:  Dihydrostreptomycin in Topical Therapy , Arch. Dermat. & Syph. 61:648 ( (April) ) 1950;.
Sulzberger, M. B., in discussion on Miller and others.3
Kile, R. L.; Welsh, A. L., and McAfee, G. D.:  Topical Use of Neomycin , Arch. Dermat. & Syph. 62:911 ( (Dec.) ) 1950;.
Hobby, G. L.; Lenert, T. F., and Dougherty, N.:  Newer Antibiotics: Factors Influencing Their Antimicrobial Activity , Ann. New York Acad. Sc. 53:27 ( (Aug. 30) ) 1950;.
Duncan, G. G.; Clancy, C. F.; Wolgamot, J. R., and Beidleman, B.:  Neomycin: Results of Clinical Use in 10 Cases , J. A. M. A. 145:75 ( (Jan. 13) ) 1951;.
Derzavis, J. L.; Rice, J. S., and Leland, L. S.:  Topical Bacitracin Therapy of Pyogenic Dermatoses , J. A. M. A. 141:191 ( (Sept. 17) ) 1949;.
Meleney, F. L., and Johnson, B. A.:  Bacitracin Therapy: The First 100 Cases of Surgical Infections Treated Locally with the Antibiotic , J. A. M. A. 133:675 ( (March 8) ) 1947;.
Johnson, B. A.; Anker, H., and Meleney, F. L.:  Bacitracin: A New Antibiotic Produced by a Member of the B. Subtilis Group , Science 102:376 ( (Oct. 12) ) 1945;.
Eagle, H.; Musselman, A. D., and Fleischman, R.:  The Action of Bacitracin and Subtilin on Treponema Pallidum in Vitro and in Vivo , J. Bact. 55:347 ( (March) ) 1948;.
Stansly, P. G.; Shepherd, R. G., and White, H. J.:  Polymyxin: A New Chemotherapeutic Agent , Bull. Johns Hopkins Hosp. 81:43 ( (July) ) 1947;.
Brownlee, G.:  Antibiotics Derived from Bacillus Polymyxa , Ann. New York Acad. Sc. 51:875 ( (June 22) ) 1949;.
Jones, T. S. G.:  Chemical Evidence for the Multiplicity of the Antibiotics Produced by Bacillus Polymyxa , Ann. New York Acad. Sc. 51:909 ( (June 22) ) 1949;.
Serri, F.:  Antifungal Activity of Aerosporin on Eight Species of Dermatomycetes , Compt. rend. Soc. biol. 143:362 ( (March 26) ) 1949;.
Schoenbach, E. B.; Bryer, M. S.; Bliss, E. A., and Long, P. H.:  Polymyxin: A Note on Experimental and Clinical Investigations , J. A. M. A. 136:1096 ( (April 24) ) 1948;.
Kagan, B. M.:  Influenzal Meningitis: Recovery of Case of 4 Weeks' Duration with Use of New Drug, Polymyxin B (Aerosporin) , Pediatrics 4:319 ( (Sept.) ) 1949;.
Ross, S.; Burke, F. G.; Rice, E. C.; Bischoff, H., and Washington, J. A.:  Treatment of Shigella Enteritis with Oral Streptomycin , J. A. M. A. 141:183 ( (Sept. 17) ) 1949;.
Kagan, B. M.; Krevsky, D.; Milzer, A., and Locke, M.:  Polymyxin B and Polymyxin E: Clinical and Laboratory Studies , J. Lab. & Clin. Med. 37:402 ( (March) ) 1951;.
Pulaski, E. J.; Baker, H. J.; Rosenberg, M. L., and Connell, J. F., Jr.:  Laboratory and Clinical Studies of Polymyxin B and E , J. Clin. Invest. 28:1028 ( (Sept.) ) 1949;.
Jeffries, S. F.; Nash, H. A.; Harmon, R. L.; Reynolds, D. C., and Bunde, C. A.:  A New Antibiotic Ointment Base , J. Am. Pharm. A. (Scient. Ed.), to be published.

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