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TREATMENT OF PYODERMAS WITH PENICILLIN 92: Title and subTitle BreakComparison with Neomycin and Bacitracin

HERBERT RATTNER, M.D.; H. HAROLD RODIN, M.D.
[+] Author Affiliations

Read before the Seventy-First Annual Meeting of the American Dermatological Association, Hot Springs, Va., May 23 to 26, 1951.


CHICAGO

From the Hektoen Institute, Cook County Hospital, and the Department of Dermatology, Northwestern University Medical School.


Arch Dermatol. 1952;65(6):656-662. doi:10.1001/archderm.1952.01530250020002
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SOME TIME ago the director of the Hektoen Institute, which is the division of research of the Cook County Hospital in Chicago, enlisted our cooperation for a study of several new antibiotic agents. The Institute was interested particularly in a new type of penicillin, l-ephenamine penicillin G (penicillin 92).1 It has an antibacterial spectrum which in vitro parallels that of penicillin G, but which differs from it in one important respect. l-Ephenamine penicillin G is thought to have hypoallergenic properties similar to those attributed to penicillin O.2

Although there are many excellent agents available for the topical treatment of pyogenic infections of the skin, each of them has certain limitations. The better ones are the broad-spectrum antibiotics, but even among these there is none that has proved to be effective in all cases. All the antibacterial drugs on occasion may produce allergic reactions, while some

REFERENCES

Kadison, E. R.; Ishihara, S. J., and Walters, T.:  A New Form of Penicillin with Anti-Allergic Properties , Am. Pract. & Digest Treat. 2:411 ( (May) ) 1951;.
Volini, I. F.; Shlaes, W. H., and Felsenfeld, O.:  Use of Penicillin O in Patients Hypersensitive to Penicillin G , J. A. M. A. 143:794 ( (July 1) ) 1950;.
The l-ephenamine penicillin G (``compenamine'') used in this study was supplied by Commercial Solvents Corporation, New York 17.
Johnson, B. A.; Anker, H., and Meleney, F. L.:  Bacitracin: A New Antibiotic Produced by a Member of the B. Subtilis Group , Science 102:376 ( (Oct. 12) ) 1945;.
Waksman, S. A., and Lechevalier, H. A.:  Neomycin, A New Antibiotic Active Against Streptomycin-Resistant Bacteria, Including Tuberculosis Organisms , Science 109:305 ( (March 25) ) 1949;.
Waisbren, B. A., and Spink, W. W.:  A Clinical Appraisal of Neomycin , Ann. Int. Med. 33:1099 ( (Nov.) ) 1950;.
Swart, E. A.; Romano, A. H., and Waksman, S. A.:  Fradicin, An Antifungal Agent Produced by Streptomyces Fradiae , Proc. Soc. Exper. Biol. & Med. 73:376 ( (March) ) 1950;.
Ishihara, S. J.:  Microbial Sensitivity Determinations in Small Laboratories , Laborat. Digest 14:8 ( (March) ) 1951;.
Tests were performed by S. J. Ishihara, B. S.
Leifer, W., and Steiner, K.:  Diiodohydroxyquinoline in Dermatologic Therapy , Arch. Dermat. & Syph. 62:46 ( (July) ) 1950;.
Sulzberger, M. B.; Baer, R. L.; Kanof, A., and Lowenberg, C.:  Methods for the Rapid Evaluation of the Beneficial and Harmful Effects of Agents Applied to the Human Skin , J. Invest. Dermat. 7:227 ( (Oct.) ) 1946;.

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Kadison, E. R.; Ishihara, S. J., and Walters, T.:  A New Form of Penicillin with Anti-Allergic Properties , Am. Pract. & Digest Treat. 2:411 ( (May) ) 1951;.
Volini, I. F.; Shlaes, W. H., and Felsenfeld, O.:  Use of Penicillin O in Patients Hypersensitive to Penicillin G , J. A. M. A. 143:794 ( (July 1) ) 1950;.
The l-ephenamine penicillin G (``compenamine'') used in this study was supplied by Commercial Solvents Corporation, New York 17.
Johnson, B. A.; Anker, H., and Meleney, F. L.:  Bacitracin: A New Antibiotic Produced by a Member of the B. Subtilis Group , Science 102:376 ( (Oct. 12) ) 1945;.
Waksman, S. A., and Lechevalier, H. A.:  Neomycin, A New Antibiotic Active Against Streptomycin-Resistant Bacteria, Including Tuberculosis Organisms , Science 109:305 ( (March 25) ) 1949;.
Waisbren, B. A., and Spink, W. W.:  A Clinical Appraisal of Neomycin , Ann. Int. Med. 33:1099 ( (Nov.) ) 1950;.
Swart, E. A.; Romano, A. H., and Waksman, S. A.:  Fradicin, An Antifungal Agent Produced by Streptomyces Fradiae , Proc. Soc. Exper. Biol. & Med. 73:376 ( (March) ) 1950;.
Ishihara, S. J.:  Microbial Sensitivity Determinations in Small Laboratories , Laborat. Digest 14:8 ( (March) ) 1951;.
Tests were performed by S. J. Ishihara, B. S.
Leifer, W., and Steiner, K.:  Diiodohydroxyquinoline in Dermatologic Therapy , Arch. Dermat. & Syph. 62:46 ( (July) ) 1950;.
Sulzberger, M. B.; Baer, R. L.; Kanof, A., and Lowenberg, C.:  Methods for the Rapid Evaluation of the Beneficial and Harmful Effects of Agents Applied to the Human Skin , J. Invest. Dermat. 7:227 ( (Oct.) ) 1946;.

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