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SMALLPOX VACCINE IN THE TREATMENT OF RECURRENT HERPES SIMPLEX

PAUL D. FOSTER, M.D.; A. BROOKS ABSHIER, M.D.
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Read at the Sixty-Fifth Annual Session of the Dermatology and Syphilology Section of the California Medical Association, Coronado, Calif., May 25, 1936.


LOS ANGELES; NEW YORK


Arch Dermatol. 1937;36(2):294-301. doi:10.1001/archderm.1937.01480020050006
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Vaccination with smallpox vaccine has been used for reccurrent herpes simplex in Europe for several years, but the treatment has had little publicity in America. When patients with recurrent herpes simplex are vaccinated with ordinary smallpox vaccine, the attack is shortened, and definite immunization to further attacks follows. Observations on thirty-five patients are presented in this paper; five had recurrences.

The effect of smallpox vaccination was first called to our attention in 1926, during an epidemic of smallpox in Los Angeles, when one of us (P. D. F.) had had attacks of herpes labialis so frequently that a white scar still remains. During the epidemic he was vaccinated approximately six times, and since that time no further attacks have occurred.

In the past ten years considerable scientific work has been done with filtrable viruses. The nature and physiologic properties of viruses are peculiar, and all visible criteria are new and

REFERENCES

Brain, R. T.:  Viruses and Skin Diseases , Brit. M. J. 2:191-194 ( (July 29) ) 1933;.
Rivers, T. M.: Filterable Viruses , Baltimore, Williams & Wilkins Company, 1928;.
Aldershoff, H., and Broers, C. M.:  Contribution à l'étude des corps intraépithéliaux de Guarnieri , Ann. Inst. Pasteur 20:779-784, 1906;.
Rivers, T. M.; Haagen, E., and Muckenfuss, R. S.:  Development in Tissue Cultures of the Intracellular Changes Characteristic of Vaccinal and Herpetic Infections , J. Exper. Med. 50:665-672 ( (Nov.) ) 1929;.
Grüter, W.:  Weitere Untersuchungen über die Vaccineimmunität des Auges , Ber. ü. d. Versamml. d. ophth. Gesellsch. 37:269-275, 1912;.
Kraupa, E.:  Zu Grüters ätiologischen Untersuchungen über den fieberhaften Herpes , München. med. Wchnschr. 6:769, 1919;.
Löwenstein, A.:  Aetiologische Untersuchungen über den fieberhaften Herpes , München. med. Wchnschr. 66:769, 1919;.
Doerr, R., and Vöchting, K.:  Etudes sur le virus de l'herpès fébrile , Rev. gén. d'opht. 34:409-421 ( (Oct.) ) 1920;.
Gay, F. P., and Holden, M.:  Loss of Viricidal Property in Serums from Patients with Herpes and Encephalitis , J. A. M. A. 96:2028-2029 ( (June 13) ) 1931;.
Lipschütz, B., and Kundratitz, K.:  Ueber die Aetiologie des zoster und über seine Beziehungen zu Varizellen , Wien. klin. Wchnschr. 39:499-503 ( (May 7) ) 1925;.
Siegl, J.:  Zum ätiologischen Zusammenhang von Herpes zoster und Varizellen , München. med. Wchnschr. 74:189 ( (Feb. 4) ) 1927;.
Bruusgaard, E.:  Mutual Relation Between Zoster and Varicella , Brit. J. Dermat. 44:1-24 ( (Jan.) ) 1932;.
Netter, A., and Urbain, A.:  Le virus varicello-zonateux , Ann. Inst. Pasteur 46:17-26 ( (Jan.) ) 1931;.
Bedson, S. P., and Bland, J. O. W.:  Simple Method of Determining Electrical Charge Carried by Virus Particles , Brit. J. Exper. Path. 10:67-70 ( (Feb.) ) 1929;.
Levaditi, C.; Harvier, P., and Nicolau, S.:  Etude expérimentale de l'encéphalite dite "léthargique ," Ann. Inst. Pasteur 36:63-101 ( (Jan.) ) 1922;.
Bastai, P., and Busacca, A.:  L'infezione erpetica umana. (Herpes.) Sua patogenesi, pretesi rapporti colla encefalite epidemica , Schweiz. Arch. f. Neurol. u. Psychiat. 15:176-238, 1924;
16:56-85, 1925
Hruszek, H.:  Impfversuche mit Eigenspeichel zum Nachweis des Herpesvirus , Dermat. Wchnschr. 96:677-680 ( (May 20) ) 1933;.
Hruszek, H.:  Versuche über die Resistenz des Herpesvirus , Dermat. Wchnschr. 98:73-78 ( (Jan. 20) ) 1934;.
Hruszek, J.:  Ueber die Virulenz-bzw. Infektiositätsunterschiede verschiedener Herpesstämme , Dermat. Wchnschr. 98:672-682 ( (June 2) ) 1934;.
Gildemeister, E., and Herzberg, K.:  Weitere Versuche über Immunitätsbeziehungen zwischen Herpes und Pocken , Deutsche med. Wchnschr. 53:138 ( (Jan. 21) ) 1927;.
Freund, H.:  Die Behandlung des rezidivierenden Herpes mit Kuhpockenlymphe , Deutsche med. Wchnschr. 54:356-357 ( (March 2) ) 1928;.
Schmidt, F. R.:  Vaccination for Herpes , Arch. Dermat. & Syph. 32: 106 ( (July) ) 1935;.
Minami, S., and Ohmichi, N.:  Klinische Erfahrungen mit Vakzination bei Herpes Genitalis , Jap. J. Dermat. & Urol. 30:54-56 ( (May) ) 1930;.
Brain, R. T.:  Biological Therapy in Virus Diseases , Brit. J. Dermat. 48: 21-26 ( (Jan.) ) 1936;.

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Brain, R. T.:  Viruses and Skin Diseases , Brit. M. J. 2:191-194 ( (July 29) ) 1933;.
Rivers, T. M.: Filterable Viruses , Baltimore, Williams & Wilkins Company, 1928;.
Aldershoff, H., and Broers, C. M.:  Contribution à l'étude des corps intraépithéliaux de Guarnieri , Ann. Inst. Pasteur 20:779-784, 1906;.
Rivers, T. M.; Haagen, E., and Muckenfuss, R. S.:  Development in Tissue Cultures of the Intracellular Changes Characteristic of Vaccinal and Herpetic Infections , J. Exper. Med. 50:665-672 ( (Nov.) ) 1929;.
Grüter, W.:  Weitere Untersuchungen über die Vaccineimmunität des Auges , Ber. ü. d. Versamml. d. ophth. Gesellsch. 37:269-275, 1912;.
Kraupa, E.:  Zu Grüters ätiologischen Untersuchungen über den fieberhaften Herpes , München. med. Wchnschr. 6:769, 1919;.
Löwenstein, A.:  Aetiologische Untersuchungen über den fieberhaften Herpes , München. med. Wchnschr. 66:769, 1919;.
Doerr, R., and Vöchting, K.:  Etudes sur le virus de l'herpès fébrile , Rev. gén. d'opht. 34:409-421 ( (Oct.) ) 1920;.
Gay, F. P., and Holden, M.:  Loss of Viricidal Property in Serums from Patients with Herpes and Encephalitis , J. A. M. A. 96:2028-2029 ( (June 13) ) 1931;.
Lipschütz, B., and Kundratitz, K.:  Ueber die Aetiologie des zoster und über seine Beziehungen zu Varizellen , Wien. klin. Wchnschr. 39:499-503 ( (May 7) ) 1925;.
Siegl, J.:  Zum ätiologischen Zusammenhang von Herpes zoster und Varizellen , München. med. Wchnschr. 74:189 ( (Feb. 4) ) 1927;.
Bruusgaard, E.:  Mutual Relation Between Zoster and Varicella , Brit. J. Dermat. 44:1-24 ( (Jan.) ) 1932;.
Netter, A., and Urbain, A.:  Le virus varicello-zonateux , Ann. Inst. Pasteur 46:17-26 ( (Jan.) ) 1931;.
Bedson, S. P., and Bland, J. O. W.:  Simple Method of Determining Electrical Charge Carried by Virus Particles , Brit. J. Exper. Path. 10:67-70 ( (Feb.) ) 1929;.
Levaditi, C.; Harvier, P., and Nicolau, S.:  Etude expérimentale de l'encéphalite dite "léthargique ," Ann. Inst. Pasteur 36:63-101 ( (Jan.) ) 1922;.
Bastai, P., and Busacca, A.:  L'infezione erpetica umana. (Herpes.) Sua patogenesi, pretesi rapporti colla encefalite epidemica , Schweiz. Arch. f. Neurol. u. Psychiat. 15:176-238, 1924;
16:56-85, 1925
Hruszek, H.:  Impfversuche mit Eigenspeichel zum Nachweis des Herpesvirus , Dermat. Wchnschr. 96:677-680 ( (May 20) ) 1933;.
Hruszek, H.:  Versuche über die Resistenz des Herpesvirus , Dermat. Wchnschr. 98:73-78 ( (Jan. 20) ) 1934;.
Hruszek, J.:  Ueber die Virulenz-bzw. Infektiositätsunterschiede verschiedener Herpesstämme , Dermat. Wchnschr. 98:672-682 ( (June 2) ) 1934;.
Gildemeister, E., and Herzberg, K.:  Weitere Versuche über Immunitätsbeziehungen zwischen Herpes und Pocken , Deutsche med. Wchnschr. 53:138 ( (Jan. 21) ) 1927;.
Freund, H.:  Die Behandlung des rezidivierenden Herpes mit Kuhpockenlymphe , Deutsche med. Wchnschr. 54:356-357 ( (March 2) ) 1928;.
Schmidt, F. R.:  Vaccination for Herpes , Arch. Dermat. & Syph. 32: 106 ( (July) ) 1935;.
Minami, S., and Ohmichi, N.:  Klinische Erfahrungen mit Vakzination bei Herpes Genitalis , Jap. J. Dermat. & Urol. 30:54-56 ( (May) ) 1930;.
Brain, R. T.:  Biological Therapy in Virus Diseases , Brit. J. Dermat. 48: 21-26 ( (Jan.) ) 1936;.

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