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Correspondence |

Candy's Dandy but Cantharidin's Quicker

Scott A. Norton, MD, MPH
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Copyright 2002 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

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Arch Dermatol. 2002;138(10):1378-1378. doi:10-1001/pubs.Arch Dermatol.-ISSN-0003-987x-138-10-dlt1002
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Cantharidin1 is a true aphrodisiac after all—except that it doesn't work in humans. Recent studies on the chemical ecology of the fire-colored beetle (Neopyrochroa flabellata—which, by the way, is not a blister beetle) show that males use cantharidin both to entice prospective mates and as a midcopulatory gift.2 3 Males ingest exogenous cantharidin, presumably obtained from an ordinary oedermid or meliodid blister beetle, and then secrete it for display on their heads. This presentation attracts female fire-colored beetles that nibble it during copulation. The eggs that these females lay, laden with cantharidin, are better protected from predatory insects than are eggs without cantharidin. Males without a cephalic display of cantharidin are usually rejected as prospective mates.

It seems to me that any substance that can be eaten—or worn on one's head—to increase one's copulatory success deserves to be called an aphrodisiac.

REFERENCES

Moed  L, Shwayder  TA, Chang  MW. Cantharidin revisited: a blistering defense of an ancient medicine. Arch Dermatol. 2001;1371357- 1360
Eisner  T, Smedley  SR, Young  DK, Eisner  M, Roach  B, Meinwald  J. Chemical basis of courtship in a beetle (Neopyrochroa flabellata): cantharidin as precopulatory "enticing" agent. Proc Natl Acad Sci U S A. 1996;936494- 6498
CrossRef
Eisner  T, Smedley  SR, Young  DK, Eisner  M, Roach  B, Meinwald  J. Chemical basis of courtship in a beetle (Neopyrochroa flabellata): cantharidin as "nuptial gift." Proc Natl Acad Sci U S A. 1996;936499- 6503
CrossRef

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Moed  L, Shwayder  TA, Chang  MW. Cantharidin revisited: a blistering defense of an ancient medicine. Arch Dermatol. 2001;1371357- 1360
Eisner  T, Smedley  SR, Young  DK, Eisner  M, Roach  B, Meinwald  J. Chemical basis of courtship in a beetle (Neopyrochroa flabellata): cantharidin as precopulatory "enticing" agent. Proc Natl Acad Sci U S A. 1996;936494- 6498
CrossRef
Eisner  T, Smedley  SR, Young  DK, Eisner  M, Roach  B, Meinwald  J. Chemical basis of courtship in a beetle (Neopyrochroa flabellata): cantharidin as "nuptial gift." Proc Natl Acad Sci U S A. 1996;936499- 6503
CrossRef

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