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In the observational study by Leachman et al,1 the authors state that "loss of bone density [in the isotretinoin-treated subjects, detected in the Ward triangle; P = .03] occurring in the absence of measurable alterations of calcium metabolism is likely to be a direct effect of retinoids on bone." No speculation was made on the likely cause of the loss in bone density in the control group, detected in the femoral neck (P = .04). I believe that the only valid conclusion to be drawn from this report is that we do not know whether 1 course of isotretinoin therapy causes a significant change in bone mineral density in some or any patients.
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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