Department of Dermatology University of Genoa V le Benedetto XV, 7 Genoa, Italy 16132
The statement by Lebbé et al1 that the detection of human herpesvirus (HHV) 8 sequences in peripheral blood mononuclear cells (PBMCs) of patients with Kaposi sarcoma (KS) is related to the tumor burden seems hazardous. This conclusion is contrary to all we know of HHV biological behavior. For none of the HHVs has the amount or even the existence of latently infected cells been correlated with a clinical disease or viral diffusion in other tissues. Indeed, some, if not all, of the known HHVs are carried by PBMCs in healthy individuals. For example, in Italy, using polymerase chain reaction (PCR), we recently detected HHV-7 DNA sequences in PBMCs in 11 (44%) of 25 healthy individuals.2 As for HHV-8, its sequence has been detected in the blood of healthy individuals. This virus is so widespread that in the American population approximately 25% of adults and 2% to 8% of children
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
Instructions
Comments are moderated and will appear on the site at the discretion of the Archives of Dermatology editors. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest* Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more
Subscribe for full-text access to content from 1998 forward and a host of useful features
Activate your current subscription (AMA members and current subscribers)
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Customize your page view by dragging & repositioning the boxes below.
and access these and other features:
Register Now
Enter your username and email address. We'll send you a reminder to the email address on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.