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Punctate and Linear Angiectases

Karla Werninghaus, MD; Regina Raab, MD; Michael Palko, MD; Jag Bhawan, MD
[+] Author Affiliations

Boston (Mass) University School of Medicine


Arch Dermatol. 1995;131(1):85-86. doi:10.1001/archderm.1995.01690130087017
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REPORT OF A CASE  A 44-year-old white man was seen for a minor dermatitis. He noted no changes in his skin. His recent history was remarkable for chronic renal failure (requiring peritoneal dialysis), hypertension, mild hypothyroidism, chronic sinusitis, and trigeminal neuralgia. As a young adult, he experienced three spontaneous pneumothoraces necessitating cautery. During childhood, he suffered from heat intolerance associated with hypohidrosis. He had no history of bleeding disorders. Family history was noncontributory and family members were not examined. His medications were carpamazepine, nifedipine, levothyroxine, and calcitriol.Complete skin examination revealed linear and macular telangiectases of the lips (Figure 1), buccal mucosa, and upper trunk. Several 1- to 2-mm red papules were present on the thighs, scrotum, and umbilicus (Figure 2). A punch biopsy specimen from an abdominal lesion is shown in Figure 3 and Figure 4. On slit lamp examination of the eyes, faint radial lens and corneal

REFERENCES

Wallace HJ.  Anderson-Fabry disease . Br J Dermatol. 1973;;88:1-23.
Desnick RJ, Astrin KH, Bishop DF.  Fabry disease . Adv Nephrol. 1989;;18:113-128.
Imperial R, Helwig EB.  Angiokeratoma . Arch Dermatol. 1967;;95:166-175.
Chesser RS, Gentry RH, Fitzpatrick JE.  Perioral telangiectases . Arch Dermatol. 1990;;126:1655.
Beratis NG, Varvarigou-Frimas A, Beratis S, et al.  Angiokeratoma corporis diffusum in Gm1 gangliosidosis, type 1 . Clin Genet. 1989;;36:59-64.
Holmes RC, Fensom AH, McKee P, et al.  Angiokeratoma corporis diffusum in a patient with normal enzyme activities . J Am Acad Dermatol. 1984;;10:384-387.
Hashimoto K, Lieberman P, Lamkin N.  Angiokeratoma corporis diffusum (Fabry disease) . Arch Dermatol. 1976;;112:1416-1423.
Luderschmidt C, Wolff HH.  Subtle clues to diagnosis of skin diseases by electron microscopy . Am J Dermatopathol. 1980;;2:57-61.
Morgan SH, Rudge P, Smith SJM, et al.  The neurologic complications of Anderson-Fabry disease (α-galactosidase A deficiency) . Q J Med. 1990;;75:491-504.
Ohkubo H.  Several functional and fluorescein fundus angiographic findings in Fabry's disease . Ophthalmologica . 1988;;196:132-136.
Mosnier JF, Degott C, Bedrossian J, et al.  Recurrence of Fabry's disease in a renal allograft 11 years after successful renal transplantation . Transplantation . 1991;;51:759-762.
Desnick RJ, Dean KJ, Grabowski GA, et al.  Enzyme therapy XVII . Birth Defects . 1980;;16:393-413.
Hasholt L, Wandell A, Sorensen A.  Enzyme replacement in Fabry endothelial cells and fibroblasts . Clin Genet. 1988;;33:360-371.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Wallace HJ.  Anderson-Fabry disease . Br J Dermatol. 1973;;88:1-23.
Desnick RJ, Astrin KH, Bishop DF.  Fabry disease . Adv Nephrol. 1989;;18:113-128.
Imperial R, Helwig EB.  Angiokeratoma . Arch Dermatol. 1967;;95:166-175.
Chesser RS, Gentry RH, Fitzpatrick JE.  Perioral telangiectases . Arch Dermatol. 1990;;126:1655.
Beratis NG, Varvarigou-Frimas A, Beratis S, et al.  Angiokeratoma corporis diffusum in Gm1 gangliosidosis, type 1 . Clin Genet. 1989;;36:59-64.
Holmes RC, Fensom AH, McKee P, et al.  Angiokeratoma corporis diffusum in a patient with normal enzyme activities . J Am Acad Dermatol. 1984;;10:384-387.
Hashimoto K, Lieberman P, Lamkin N.  Angiokeratoma corporis diffusum (Fabry disease) . Arch Dermatol. 1976;;112:1416-1423.
Luderschmidt C, Wolff HH.  Subtle clues to diagnosis of skin diseases by electron microscopy . Am J Dermatopathol. 1980;;2:57-61.
Morgan SH, Rudge P, Smith SJM, et al.  The neurologic complications of Anderson-Fabry disease (α-galactosidase A deficiency) . Q J Med. 1990;;75:491-504.
Ohkubo H.  Several functional and fluorescein fundus angiographic findings in Fabry's disease . Ophthalmologica . 1988;;196:132-136.
Mosnier JF, Degott C, Bedrossian J, et al.  Recurrence of Fabry's disease in a renal allograft 11 years after successful renal transplantation . Transplantation . 1991;;51:759-762.
Desnick RJ, Dean KJ, Grabowski GA, et al.  Enzyme therapy XVII . Birth Defects . 1980;;16:393-413.
Hasholt L, Wandell A, Sorensen A.  Enzyme replacement in Fabry endothelial cells and fibroblasts . Clin Genet. 1988;;33:360-371.

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