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Rapidly Progressing Nodule in a Patient With the Acquired Immunodeficiency Syndrome

Ruth A. Yates, MD; Kenneth Sabe, MD; Carmen Arzubiaga, MD; Stephen Raffanti, MD; Lloyd King, MD
[+] Author Affiliations

Vanderbilt University, Nashville, Tenn


Arch Dermatol. 1994;130(12):1556-1556. doi:10.1001/archderm.1994.01690120097016
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REPORT OF A CASE  A 31-year-old man with the acquired immunodeficiency syndrome (AIDS) presented with a 3-month history of a rapidly progressing painful lesion of the right shoulder. Initially an infectious cause was postulated, but cultures showed only a light growth of mixed gram-positive organisms and there was no clinical response to cephalexin.His history was significant for a 3-year history of AIDS manifested by positive tests for the human immunodeficiency virus (HIV), recurrent candidiasis, herpes zoster, and AIDS dementia but no adenopathy or Kaposi's sarcoma.Physical examination revealed a 5 ×4-cm lesion of the right shoulder with central necrosis and a heaped-up smooth pearly border (Figure 1). There was no adenopathy.A biopsy specimen at the edge of the lesion was obtained for both pathologic review (Figure 2 and Figure 3) and cultures.What is your diagnosis?

Figure 1  .

Figure 2  .

Figure 3  .

Rapidly Progressing Nodule in a Patient 

REFERENCES

Kantor GR, Ranchoff RE, Tubbs RR, et al.  Primary cutaneous B-cell lymphoma . Cleve Clin Q. 1985;;52:87-93.
Myskowski PL, Straus DJ, Safai B.  Lymphoma and other HIV-associated malignancies . J Am Acad Dermatol. 1990;;22:1253-1260.
Burns MK, Kennard CD, Dubin HV.  Nodular cutaneous B-cell lymphoma of the scalp in the acquired immune deficiency syndrome . J Am Acad Dermatol. 1991;; 25:933-936.
Groopman JE, Sullivan JL, Mulder C, et al.  Pathogenesis of B cell lymphoma in a patient with AIDS . Blood . 1986;;67:612-615.
Ganser Q, Carlo-Stella C, Bartram CR, et al.  Establishment of two Epstein-Barr virus negative Burkitt cell lines from a patient with AIDS and B cell lymphoma . Blood . 1988;;72:1255-1260.

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Kantor GR, Ranchoff RE, Tubbs RR, et al.  Primary cutaneous B-cell lymphoma . Cleve Clin Q. 1985;;52:87-93.
Myskowski PL, Straus DJ, Safai B.  Lymphoma and other HIV-associated malignancies . J Am Acad Dermatol. 1990;;22:1253-1260.
Burns MK, Kennard CD, Dubin HV.  Nodular cutaneous B-cell lymphoma of the scalp in the acquired immune deficiency syndrome . J Am Acad Dermatol. 1991;; 25:933-936.
Groopman JE, Sullivan JL, Mulder C, et al.  Pathogenesis of B cell lymphoma in a patient with AIDS . Blood . 1986;;67:612-615.
Ganser Q, Carlo-Stella C, Bartram CR, et al.  Establishment of two Epstein-Barr virus negative Burkitt cell lines from a patient with AIDS and B cell lymphoma . Blood . 1988;;72:1255-1260.

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