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Chronic Skin Ulcers and the Biology of Skin Grafts

David R. Harris, MD
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3803 S Bascom Ave Campbell, CA 95008


Arch Dermatol. 1993;129(9):1204-1205. doi:10.1001/archderm.1993.01680300134026
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For those of us who treat chronic skin ulcers, the review article entitled "The Biology of Skin Grafts" by Kirsner et al1 in the April 1993 issue of the Archives was of special interest. The authors noted a common phenomenon that all who do skin grafting see with regularity. They observed that transferred live keratinocytes, whether they survive or are incorporated into the healed integument in the future, seem to greatly speed the healing of chronic wounds. Any clinician who transfers live keratinocytes with skin grafts to a chronic wound bed has noticed that there is a remarkable improvement in the wound over several days of observation, even if the graft does not "take." The wound bed seems to develop healthier granulations; obviously new growth of blood vessels has taken place. Moreover, there is movement from the wound edge, with migrating epidermis noted by a soft dull pinkness progressing

REFERENCES

Kirsner RS, Falanga V, Eaglstein WH.  The biology of skin grafts . Arch Dermatol. 1993;;129:481-483.
Phillips TJ, Kehinde O, Green H, Gilchrest BA.  Treatment of skin ulcers with cultured epidermal allografts . J Am Acad Dermatol. 1989;;21:191-199.
De Luca M, Albanese E, Cancedda R, et al.  Treatment of leg ulcers with cryopreserved allogenic cultured epithelium . Arch Dermatol. 1992;;128:633-638.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Kirsner RS, Falanga V, Eaglstein WH.  The biology of skin grafts . Arch Dermatol. 1993;;129:481-483.
Phillips TJ, Kehinde O, Green H, Gilchrest BA.  Treatment of skin ulcers with cultured epidermal allografts . J Am Acad Dermatol. 1989;;21:191-199.
De Luca M, Albanese E, Cancedda R, et al.  Treatment of leg ulcers with cryopreserved allogenic cultured epithelium . Arch Dermatol. 1992;;128:633-638.

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