University of Texas Medical Branch 1405 Marine Dr Galveston, TX 77550
To the Editor.— The interesting association of protein C and protein S deficiency to lipodermatosclerosis and venous ulceration was reviewed in the September 1990 issue of the Archives.1 In discussing the function of protein C the authors appropriately state that protein C inactivates coagulation factors V and VIII in their activated form. In their conclusion, they comment that "An increased propensity for deep venous thrombosis, as could occur in the setting of protein C or protein S deficiency and perhaps in combination with a faulty fibrinolytic system, may lead to the development of venous occlusion and venous hypertension."Besides its function in preventing fibrin formation via inhibition of coagulation factors Va and VIIIa,2 activated protein C also serves a profibrinolytic function. Among the many proteins essential for normal fibrinolytic function are the plasminogen activator inhibitors, which prevent the formation of plasmin necessary for fibrinolysis.3 Plasminogen activator inhibitor
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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