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July 1991, Vol 127, No. 7 >
Article | July 1991

Cutaneous T-Cell Lymphoma and Human Immunodeficiency Virus: Title and subTitle BreakThe Spectrum Broadens

Patricia L. Myskowski, MD
[+] Author Affiliations

Dermatology Service Department of Medicine Memorial Sloan-Kettering Cancer Center 1275 York Ave New York, NY 10021


Arch Dermatol. 1991;127(7):1045-1047. doi:10.1001/archderm.1991.01680060119017
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Comments

As the epidemic of acquired immunodeficiency syndrome (AIDS) continues, it has become well recognized that individuals infected with the human immunodeficiency virus (HIV) are at increased risk for the development of various cancers. In this issue of the Archives, Crane et al1 and Nahass and coworkers2 describe five patients with documented HIV infection, who developed skin diseases that were believed to represent cutaneous T-cell lymphoma (CTCL). These findings, at first, seem to challenge our conventional views on both diseases. How can CTCL—most commonly seen as a proliferation of CD4+ helper T lymphocytes— develop in an individual with AIDS, in whom these same helper T cells are progressively destroyed by HIV? To accept the coexistence of HIV infection and CTCL as other than a mere coincidence, one must reexamine the pathogenesis of malignancies in HIV infection, as well as the diverse nature of malignant T cells in the skin.

REFERENCES

1 +
Crane GA, Variakojis D, Rosen ST, Sands AM, Roenigk HH.  Cutaneous T-cell lymphoma in patients with human immunodeficiency virus infection . Arch Dermatol. 1991;;127:989-994.
2 +
Nahass GT, Kraffart CA, Penneys NS.  Cutaneous T-cell lymphoma associated with the acquired immunodeficiency syndrome . Arch Dermatol. 1991;;127:1020-1022.
3 +
Myskowski PM, Straus DJ, Safai B.  Lymphoma and other HIV-associated malignancies . J Am Acad Dermatol. 1990;;22:1253-1260.
4 +
Fauci AS, Macher AM, Longo DL, et al.  Acquired immunodeficiency syndrome: epidemiologic, clinical and therapeutic considerations . Ann Intern Med. 1984;;100:92-106.
5 +
Birkeland SA.  Malignant tumors in renal transplant recipients: the Scandia transplant material . Cancer. 1983;;51:1571-1575.
6 +
Penn I.  Cancers complicating organ transplantation . N Engl J Med. 1990;;323:1767-1769.
7 +
Spector BD, Perry GS, Jersey JN.  Genetically determined immunodeficiency disease malignancy: report from the immunodeficiency cancer registry . Clin Immunol Immunopathol. 1978;;11: 12-29.
8 +
Rubin RH, Cosimi AB, Tolkoff-Rubin NE, Russell PS, Hirsch MS.  Infectious disease syndromes attributable to cytomegalovirus and their significance among renal transplant recipients . Transplantation. 1977;;24:458-464.
9 +
Drew WL, Miner RC, Ziegler JC, et al.  Cytomegalovirus and Kaposi's sarcoma in young homosexual men . Lancet. 1982;;1:125-127.
10 +
Giraldo G, Beth E, Henle W, et al.  Antibody patterns to herpes viruses in Kaposi's sarcoma, II: serological association of American Kaposi's sarcoma with cytomegalovirus . Int J Cancer. 1978;;22:126-131.
11 +
Boldogh I, Beth E, Huang E-S, Kyalwazi SK, Giraldo G.  Kaposi's sarcoma, IV: detection of CMV DNA, CMV RNA, and CMV NA in tumour biopsies . Int J Cancer. 1981;;28:469-474.
12 +
Friedman-Kien AE, Saltzman BR, Cao Y, et al.  Kaposi's sarcoma in HIV-negative homosexual men . Lancet. 1990;;335:168-169.
13 +
Purtilo DT.  Epstein Barr virus-induced oncognesis in immune deficient individuals . Lancet. 1980;;1:300-303.
14 +
Birx DL, Redfield RR, Tosato G.  Defective regulation of Epstein-Barr virus infection in patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related disorders . N Engl J Med. 1986;;314:874-879.
15 +
Lane CH, Masur H, Edgar LC, Whalen G, Rook AH, Fauci AS.  Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome . N Engl J Med. 1983;;309:453-458.
16 +
Hochberg FH, Miller G, Schooley RT, et al.  Central nervous system lymphoma related to Epstein-Barr virus . N Engl J Med. 1983;;309:745-748.
17 +
Peterson JM, Tubbs RR, Savage RA, et al.  Small non-cleaved B-cell Burkitt-like lymphoma with chromosome t(8:14) translocation and Epstein-Barr virus nuclear-associated antigen in a homosexual man with acquired immune deficiency syndrome . Am J Med. 1985;;78:141-148.
18 +
Harper ME, Kaplan MH, Marselle LM, Pahwa SG, Sarngadharan MG, Gallo RC.  Concomitant infection with HTLV-I and HTLV-III in a patient with T8 lymphoproliferative disease . N Engl J Med. 1986;;315:1073-1078.
19 +
Shibata D, Brynes RK, Rabinowitz A, et al.  Human T-cell lymphotropic virus type I (HTLV-I)-associated adult T-cell leukemia-lymphoma in a patient infected with human immunodeficiency virus type 1 (HIV-1) . Ann Intern Med. 1989;;3:871-875.
20 +
Bartholomew C, Saxinger WC, Clark JW, et al.  Transmission of HTLV-I and HIV among homosexual men in Trinidad . JAMA. 1987;;257:2604-2608.
21 +
Baurmann H, Miclea JM, Ferchal F, et al.  Adult T-cell leukemia associated with HTLV-I and simultaneous infection by human immunodeficiency virus type 2 and human herpesvirus 6 in African women: a clinical, virologic, and familial study . Am J Med. 1988;;85:853-857.
22 +
Ehrlich GD, Davey Fr, Kirshner JJ, et al.  A polyclonal CD4+ and CD8+ lymphocytosis in a patient doubly infected with HTLV-I and HIV-1: a clinical and molecular analysis . Am J Hematol. 1989;;30:128-139.
23 +
Nasr SA, Brynes RK, Garrison CP, Chan WC.  Peripheral T-cell lymphoma in a patient with acquired immune deficiency syndrome . Cancer. 1988;;61:947-951.
24 +
Presant CA, Gala K, Wiseman C, et al.  Human immunodeficiency virus-associated T-cell lymphoblastic lymphoma in AIDS . Cancer. 1987;;60:1459-1461.
25 +
Kobayashi MD, Yoshimoto S, Fujishita M, et al.  HTLV-I positive T-cell lymphoma/leukemia in an AIDS patient . Lancet. 1984;;1:1361-1362.
26 +
Goldstein J, Becker N, DelRowe J, Davis L.  Cutaneous T-cell lymphoma in a patient infected with human immunodeficiency virus type I: use of radiation therapy . Cancer. 1990;;66:1130-1132.
27 +
Knowles DM, Chamulak GA, Subar M, et al.  Lymphoid neoplasia associated with the acquired immunodeficiency syndrome (AIDS): The New York University Medical Center Experience (1981-1986) . Ann Intern Med. 1988;;18:744-754.
28 +
Lust JA, Banks PM, Hooper WC, et al.  T-cell non-Hodgkin lymphoma in human immunodeficiency virus-1-infected individuals . Am J Hematol. 1989;;31:181-187.
29 +
Parker SC, Fenton DA, McGibbon DH.  Homme Rouge and the acquired immunodeficiency syndrome . N Engl J Med. 1989;;321:906-910.
30 +
Janier M, Katlama C, Flageul B, et al.  The pseudo-Sézary syndrome with CD8 phenotype in a patient with an acquired immunodeficiency syndrome (AIDS) . Ann Intern Med. 1989;;110:738-740.
31 +
Wachter H, Fuchs D, Hausen A, et al.  Are conditions linked with T-cell stimulation necessary for progressive HTLV-III infection? Lancet. 1986;;1:97.
32 +
Fisher AG, Feinberg MB, Josephs SF, et al.  The trans-activator gene of HTLV-III is essential for virus replication . Nature. 1986;;320:367-370.
33 +
Sordorski J, Rosen C, Wong-Staal F, et al.  Trans-acting transcriptional regulation of human T-cell leukemia virus type III long terminal repeat . Science. 1985;;227:171-173.
34 +
Jones JF, Shurin S, Abramowsky C, et al.  T-cell lymphoma containing Epstein-Barr viral DNA in patients with chronic Epstein-Barr virus infections . N Engl J Med. 1988;;318:733.
35 +
Su IJ, Lin KH, Chen CJ, et al.  Epstein-Barr virus-associated peripheral T-cell lymphoma of activated CD8 phenotype . Cancer . 1988;;66:2557-2562.
36 +
Lee PYP, Charley M, Tharp M, Jegasothy BV, Deng JS.  Possible role of Epstein-Barr virus infection in cutaneous T-cell lymphomas . J Invest Dermatol. 1990;;95:309-312.
37 +
Fingeroth JD, Weiss JJ, Tedder RF, Strominger JC, Biro PA, Fearon DT.  Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor Cr2 . Proc Natl Acad Sci U S A. 1984;;81:4510-4514.
38 +
Shore A, Dosch HM, Gelfand EW.  Expression and modulation of C3 receptors during early T-cell ontogeny . Cell Immunol. 1979;;45:157-166.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Crane GA, Variakojis D, Rosen ST, Sands AM, Roenigk HH.  Cutaneous T-cell lymphoma in patients with human immunodeficiency virus infection . Arch Dermatol. 1991;;127:989-994.
2 +
Nahass GT, Kraffart CA, Penneys NS.  Cutaneous T-cell lymphoma associated with the acquired immunodeficiency syndrome . Arch Dermatol. 1991;;127:1020-1022.
3 +
Myskowski PM, Straus DJ, Safai B.  Lymphoma and other HIV-associated malignancies . J Am Acad Dermatol. 1990;;22:1253-1260.
4 +
Fauci AS, Macher AM, Longo DL, et al.  Acquired immunodeficiency syndrome: epidemiologic, clinical and therapeutic considerations . Ann Intern Med. 1984;;100:92-106.
5 +
Birkeland SA.  Malignant tumors in renal transplant recipients: the Scandia transplant material . Cancer. 1983;;51:1571-1575.
6 +
Penn I.  Cancers complicating organ transplantation . N Engl J Med. 1990;;323:1767-1769.
7 +
Spector BD, Perry GS, Jersey JN.  Genetically determined immunodeficiency disease malignancy: report from the immunodeficiency cancer registry . Clin Immunol Immunopathol. 1978;;11: 12-29.
8 +
Rubin RH, Cosimi AB, Tolkoff-Rubin NE, Russell PS, Hirsch MS.  Infectious disease syndromes attributable to cytomegalovirus and their significance among renal transplant recipients . Transplantation. 1977;;24:458-464.
9 +
Drew WL, Miner RC, Ziegler JC, et al.  Cytomegalovirus and Kaposi's sarcoma in young homosexual men . Lancet. 1982;;1:125-127.
10 +
Giraldo G, Beth E, Henle W, et al.  Antibody patterns to herpes viruses in Kaposi's sarcoma, II: serological association of American Kaposi's sarcoma with cytomegalovirus . Int J Cancer. 1978;;22:126-131.
11 +
Boldogh I, Beth E, Huang E-S, Kyalwazi SK, Giraldo G.  Kaposi's sarcoma, IV: detection of CMV DNA, CMV RNA, and CMV NA in tumour biopsies . Int J Cancer. 1981;;28:469-474.
12 +
Friedman-Kien AE, Saltzman BR, Cao Y, et al.  Kaposi's sarcoma in HIV-negative homosexual men . Lancet. 1990;;335:168-169.
13 +
Purtilo DT.  Epstein Barr virus-induced oncognesis in immune deficient individuals . Lancet. 1980;;1:300-303.
14 +
Birx DL, Redfield RR, Tosato G.  Defective regulation of Epstein-Barr virus infection in patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related disorders . N Engl J Med. 1986;;314:874-879.
15 +
Lane CH, Masur H, Edgar LC, Whalen G, Rook AH, Fauci AS.  Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome . N Engl J Med. 1983;;309:453-458.
16 +
Hochberg FH, Miller G, Schooley RT, et al.  Central nervous system lymphoma related to Epstein-Barr virus . N Engl J Med. 1983;;309:745-748.
17 +
Peterson JM, Tubbs RR, Savage RA, et al.  Small non-cleaved B-cell Burkitt-like lymphoma with chromosome t(8:14) translocation and Epstein-Barr virus nuclear-associated antigen in a homosexual man with acquired immune deficiency syndrome . Am J Med. 1985;;78:141-148.
18 +
Harper ME, Kaplan MH, Marselle LM, Pahwa SG, Sarngadharan MG, Gallo RC.  Concomitant infection with HTLV-I and HTLV-III in a patient with T8 lymphoproliferative disease . N Engl J Med. 1986;;315:1073-1078.
19 +
Shibata D, Brynes RK, Rabinowitz A, et al.  Human T-cell lymphotropic virus type I (HTLV-I)-associated adult T-cell leukemia-lymphoma in a patient infected with human immunodeficiency virus type 1 (HIV-1) . Ann Intern Med. 1989;;3:871-875.
20 +
Bartholomew C, Saxinger WC, Clark JW, et al.  Transmission of HTLV-I and HIV among homosexual men in Trinidad . JAMA. 1987;;257:2604-2608.
21 +
Baurmann H, Miclea JM, Ferchal F, et al.  Adult T-cell leukemia associated with HTLV-I and simultaneous infection by human immunodeficiency virus type 2 and human herpesvirus 6 in African women: a clinical, virologic, and familial study . Am J Med. 1988;;85:853-857.
22 +
Ehrlich GD, Davey Fr, Kirshner JJ, et al.  A polyclonal CD4+ and CD8+ lymphocytosis in a patient doubly infected with HTLV-I and HIV-1: a clinical and molecular analysis . Am J Hematol. 1989;;30:128-139.
23 +
Nasr SA, Brynes RK, Garrison CP, Chan WC.  Peripheral T-cell lymphoma in a patient with acquired immune deficiency syndrome . Cancer. 1988;;61:947-951.
24 +
Presant CA, Gala K, Wiseman C, et al.  Human immunodeficiency virus-associated T-cell lymphoblastic lymphoma in AIDS . Cancer. 1987;;60:1459-1461.
25 +
Kobayashi MD, Yoshimoto S, Fujishita M, et al.  HTLV-I positive T-cell lymphoma/leukemia in an AIDS patient . Lancet. 1984;;1:1361-1362.
26 +
Goldstein J, Becker N, DelRowe J, Davis L.  Cutaneous T-cell lymphoma in a patient infected with human immunodeficiency virus type I: use of radiation therapy . Cancer. 1990;;66:1130-1132.
27 +
Knowles DM, Chamulak GA, Subar M, et al.  Lymphoid neoplasia associated with the acquired immunodeficiency syndrome (AIDS): The New York University Medical Center Experience (1981-1986) . Ann Intern Med. 1988;;18:744-754.
28 +
Lust JA, Banks PM, Hooper WC, et al.  T-cell non-Hodgkin lymphoma in human immunodeficiency virus-1-infected individuals . Am J Hematol. 1989;;31:181-187.
29 +
Parker SC, Fenton DA, McGibbon DH.  Homme Rouge and the acquired immunodeficiency syndrome . N Engl J Med. 1989;;321:906-910.
30 +
Janier M, Katlama C, Flageul B, et al.  The pseudo-Sézary syndrome with CD8 phenotype in a patient with an acquired immunodeficiency syndrome (AIDS) . Ann Intern Med. 1989;;110:738-740.
31 +
Wachter H, Fuchs D, Hausen A, et al.  Are conditions linked with T-cell stimulation necessary for progressive HTLV-III infection? Lancet. 1986;;1:97.
32 +
Fisher AG, Feinberg MB, Josephs SF, et al.  The trans-activator gene of HTLV-III is essential for virus replication . Nature. 1986;;320:367-370.
33 +
Sordorski J, Rosen C, Wong-Staal F, et al.  Trans-acting transcriptional regulation of human T-cell leukemia virus type III long terminal repeat . Science. 1985;;227:171-173.
34 +
Jones JF, Shurin S, Abramowsky C, et al.  T-cell lymphoma containing Epstein-Barr viral DNA in patients with chronic Epstein-Barr virus infections . N Engl J Med. 1988;;318:733.
35 +
Su IJ, Lin KH, Chen CJ, et al.  Epstein-Barr virus-associated peripheral T-cell lymphoma of activated CD8 phenotype . Cancer . 1988;;66:2557-2562.
36 +
Lee PYP, Charley M, Tharp M, Jegasothy BV, Deng JS.  Possible role of Epstein-Barr virus infection in cutaneous T-cell lymphomas . J Invest Dermatol. 1990;;95:309-312.
37 +
Fingeroth JD, Weiss JJ, Tedder RF, Strominger JC, Biro PA, Fearon DT.  Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor Cr2 . Proc Natl Acad Sci U S A. 1984;;81:4510-4514.
38 +
Shore A, Dosch HM, Gelfand EW.  Expression and modulation of C3 receptors during early T-cell ontogeny . Cell Immunol. 1979;;45:157-166.

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