Maternal Pemphigus Foliaceus With Cell Surface Antibody Bound in Neonatal Epidermis

Russell W. Eyre, MD; John R. Stanley, MD

[+] Author Affiliations

Dermatology Branch National Cancer Institute Bldg 10, Room 12N-238 National Institutes of Health Bethesda, MD 20892

Arch Dermatol. 1988;124(1):25-27. doi:10.1001/archderm.1988.01670010015009

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ABSTRACT

ABSTRACT | REFERENCES

To the Editor.— There are two major types of pemphigus, pemphigus foliaceus (PF), in which blisters form due to acantholysis in the superficial epidermis, and pemphigus vulgaris (PV), in which acantholysis occurs in the deeper epidermis, just above the basal layer.¹ Mucous membrane lesions, flaccid bullae, and extensive erosions are commonly seen in PV; whereas, in PF, superficial crusts and scales appear, often in a seborrheic distribution, and mucous membrane lesions or extensive erosions are rarely seen. Patients with each type of pemphigus have autoantibodies to different keratinocyte cell surface molecules.^2,3 Patients with PF have antibodies to a characteristic complex of polypeptides of 260 000,160 000, 110000, and 85 000 molecular weight (mol wt), as detected by immunoprecipitation of human epidermal extracts.³ These polypeptides include desmoglein I, a 160 000-mol wt core desmosomal glycoprotein and, possibly, other desmosomal proteins. Patients with PV have antibodies to a different, characteristic complex of polypeptides of 210000, 130000, and

REFERENCES

ABSTRACT | REFERENCES

Jordon RE: Pemphigus , in Fitzpatrick TB, Eisen AZ, Wolff K, et al (eds): Dermatology in General Medicine , ed 2. New York, McGraw-Hill International Book Co, 1987;, pp 571-579.

Stanley JR, Koulu L, Thivolet C: Distinction between epidermal antigens binding pemphigus vulgaris and pemphigus foliaceus autoantibodies . J Clin Invest 1984;;74:313-320.

Eyre RW, Stanley JR: Human autoantibodies against a desmosomal protein complex with a calcium-sensitive epitope are characteristic of pemphigus foliaceus patients . J Exp Med 1987;; 165:1719-1724.

Eyre RW, Stanley JR: Characterization of pemphigus vulgaris antigen extracted from normal human epidermis , abstracted. Clin Res 1987;;35:387.

Wasserstrum N, Laros RK: Transplacental transmission of pemphigus . JAMA 1983;;249:1480-1482.

Merlob P, Metzker A, Hazaz B, et al: Neonatal pemphigus vulgaris . Pediatrics 1986;;78:1102-1105.

Green D, Maize JC: Maternal pemphigus vulgaris with in vivo bound antibodies in the stillborn fetus . J Am Acad Dermatol 1982;; 7:388-392.

Perry HO, Brunsting LA: Pemphigus foliaceus: Further observations . Arch Dermatol 1965;;91:10-23.

Hashimoto K, Shafran KM, Webber PS, et al: Anti-cell surface pemphigus antoantibody stimulates plasminogen activator activity of human epidermal cells . J Exp Med 1983;;157:259-272.

Roscoe JT, Diaz L, Sampaio SA, et al: Brazilian pemphigus foliaceus autoantibodies are pathogenic to BALB/c mice by passive transfer . J Invest Dermatol 1985;;85:538-541.

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