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Digestive Involvement in Dystrophic Recessive Epidermolysis Bullosa

Marc Fortier-Beaulieu, MD; Yves de Prost, MD
[+] Author Affiliations

Unité de Dermatologie Hôpital Necker-Enfants Malades 149, rue de Sèvres 75743 Paris Cedex 15, France


Arch Dermatol. 1988;124(12):1870-1870. doi:10.1001/archderm.1988.01670120076021
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To the Editor.—  We read with interest the May 1988 issue of the Archives that featured articles on the nondermatologic complications of epidermolysis bullosa. We would like to go into more detail about intestinal involvement in dystrophic recessive epidermolysis bullosa (DREB).According to Holbrook1 and Gruskay,2 the simple columnar epithelium could be involved by bullous disease. There is only one detailed report, by Sehgal et al,3 about colonic involvement in DREB. This report refers to clinical and radiologic data, without presenting results from endoscopic and histologic examinations. The other radiologic studies show a normal colon. Colonic interposition is the surgical treatment for tight esophageal strictures. The good results of colonic transplants, described in the same issue, provide experimental proof of the absence of colonic involvement.4According to Gruskay,2 malabsorption could occur subsequent to digestive involvement. In our study of six cases of DREB and review

REFERENCES

Holbrook KA:  Extracutaneous epithelial involvement in inherited epidermolysis bullosa . Arch Dermatol 1988;;124:726-731.
Gruskay DM:  Nutritional management in the child with epidermolysis bullosa . Arch Dermatol 1988;;124:760-761.
Sehgal VN, Rege VL, Ghosh SK, et al:  Dystrophic epidermolysis bullosa: Interesting gastrointestinal manifestations . Br J Dermatol 1977;;96:389-392.
Gryboski JD, Touloukian R, Campanella RA:  Gastrointestinal manifestations of epidermolysis bullosa in children . Arch Dermatol 1988;;124:746-752.
Fortier-Beaulieu M, Teillac D, de Prost Y:  Atteinte digestive au cours de l'epidermolyse bulleuse dystrophique récessive . Ann Dermatol Venereol 1987;;114:963-971.

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Holbrook KA:  Extracutaneous epithelial involvement in inherited epidermolysis bullosa . Arch Dermatol 1988;;124:726-731.
Gruskay DM:  Nutritional management in the child with epidermolysis bullosa . Arch Dermatol 1988;;124:760-761.
Sehgal VN, Rege VL, Ghosh SK, et al:  Dystrophic epidermolysis bullosa: Interesting gastrointestinal manifestations . Br J Dermatol 1977;;96:389-392.
Gryboski JD, Touloukian R, Campanella RA:  Gastrointestinal manifestations of epidermolysis bullosa in children . Arch Dermatol 1988;;124:746-752.
Fortier-Beaulieu M, Teillac D, de Prost Y:  Atteinte digestive au cours de l'epidermolyse bulleuse dystrophique récessive . Ann Dermatol Venereol 1987;;114:963-971.

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