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Epidermolysis Bullosa Acquisita With Negative Direct Immunofluorescence

Peter Duschet, MD; Thomas Schwarz, MD; Fritz Gschnait, MD
[+] Author Affiliations

Department of Dermatology Vienna City Hospital-Lainz Wolkersbergenstrasse 1 A-1130 Vienna, Austria


Arch Dermatol. 1986;122(8):851-851. doi:10.1001/archderm.1986.01660200019002
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To the Editor.—  In the September 1985 issue of the Archives, a 58-year-old man suffering from epidermolysis bullosa acquisita (EBA) with negative direct immunofluorescence (IF) findings was reported by Lacour et al.1 The diagnosis of EBA was well established clinically and by electron microscopic investigations. Direct IF studies performed on six biopsy specimens over a period of two years revealed negative results; hence, the authors suggested the existence of a distinct subgroup of patients with EBA with no immunoglobulin deposits in the skin. Unfortunately, exact information concerning the skin sites from which the biopsy specimens were taken for IF investigations was not provided.Recently, Weigand2 analyzed 41 cases of histologically confirmed bullous pemphigoid and demonstrated that in lesions originating in the lower extremities a third of direct IF tests turned out negative, whereas biopsy specimens tested from all other anatomic regions were found to have negative results in

REFERENCES

Lacour J-P, Juhlin L, El Baze P, et al:  Epidermolysis bullosa acquisita with negative direct immunofluorescence . Arch Dermatol 1985;;121:1183-1185.
Weigand DA:  Effect of anatomic region on immunofluorescence diagnosis of bullous pemphigoid . J Am Acad Dermatol 1985;;12:274-278.
Duschet P, Schwarz T, Gschnait F:  Effect of anatomic location on immunofluorescence in lichen planus . J Am Acad Dermatol 1985;;13:1057.

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Lacour J-P, Juhlin L, El Baze P, et al:  Epidermolysis bullosa acquisita with negative direct immunofluorescence . Arch Dermatol 1985;;121:1183-1185.
Weigand DA:  Effect of anatomic region on immunofluorescence diagnosis of bullous pemphigoid . J Am Acad Dermatol 1985;;12:274-278.
Duschet P, Schwarz T, Gschnait F:  Effect of anatomic location on immunofluorescence in lichen planus . J Am Acad Dermatol 1985;;13:1057.

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