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September 1986, Vol 122, No. 9 >
Article | September 1986

Cutaneous Leukocytoclastic Vasculitis Complicating Hairy Cell Leukemia (Leukemic Reticuloendotheliosis)

Carrell R. Spann, MD; Jeffrey P. Callen, MD; Lung T. Yam, MD; John T. Apgar, MD
[+] Author Affiliations

Accepted for publication April 3, 1986.

Presented in part at the annual meeting of the American Academy of Dermatology, Las Vegas, Dec 7, 1985.

Reprint requests to Division of Dermatology, Department of Medicine, University of Louisville School of Medicine, 310 E Broadway, Louisville, KY 40292 (Dr Callen).


From the Divisions of Dermatology (Drs Spann and Callen) and Hematology (Dr Yam), Department of Medicine, University of Louisville School of Medicine; the Divisions of Dermatology (Dr Callen) and Hematology (Dr Yam), Department of Medicine, Veterans Administration Medical Center, Louisville; and Department of Dermatology, Emory University School of Medicine, Atlanta (Dr Apgar).


Arch Dermatol. 1986;122(9):1057-1059. doi:10.1001/archderm.1986.01660210107029
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References
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• A patient with hairy cell leukemia (HCL) receiving fluoxymesterone developed cutaneous leukocytoclastic vasculitis. His clinical picture was of purpuric papules and pustules on his chest and limbs. Oral corticosteroid therapy and colchicine therapy were tried, with only minimal improvement. Chemotherapy with pentostatin (2′-deoxycoformycin) resolved the vasculitis and placed the HCL in remission. Fifteen cases of HCL associated with vasculitis have been reported previously. Hairy cell leukemia and vasculitis appear to have more than a coincidental relationship.

(Arch Dermatol 1986;122:1057-1059)

REFERENCES

1 +
Turner A, Kjeldsberg CR:  Hairy cell leukemia: A review . Medicine 1978;;57:477-499.
2 +
Bouroncle BA, Wiseman BK, Doan CA:  Leukemic reticuloendotheliosis . Blood 1958;;13:609-630.
3 +
Schrek R, Donnelly WJ:  `Hairy cells' in blood in lymphoreticular neoplastic disease and 'flagellated' cells of normal lymph nodes . Blood 1966;;27:199-211.
4 +
Yam LT, Li C-Y, Finkel HE:  Leukemia reticuloendotheliosis . Arch Intern Med 1972;;130:248-256.
5 +
Lusch CJ, Ramsey HE, Katayam AI:  Leukemic reticuloendotheliosis: Report of a case with peripheral blood remission on androgen therapy . Cancer 1978;;41:1964-1966.
6 +
Golomb HM, Catovsky D, Golde DW:  Hairy cell leukemia: A clinical review based on 71 cases . Ann Intern Med 1978;;89:677-683.
7 +
Westbrook CA, Groopman JE, Golde DW:  Hairy cell leukemia: Disease pattern and prognosis . Cancer 1984;;54:500-506.
8 +
Bouroncle BA:  Leukemic reticuloendotheliosis (hairy cell leukemia) . Blood 1979;;53:412-436.
9 +
Hughes GRV, Elkon KB, Spiller R, et al:  Polyarteritis nodosa and hairy cell leukemia . Lancet 1979;;1:;678.
10 +
Elkon KB, Hughes GRV, Catovsky D, et al:  Hairy cell leukemia with polyarteritis nodosa . Lancet 1979;;2:280-282.
11 +
Goedert JJ, Neete JR, Smith FS, et al:  Polyarteritis nodosa, hairy cell leukemia and splenosis . Am J Med 1981;;71:323-326.
12 +
LePogamp P, Ghandour C, LePrise PY:  Hairy cell leukemia and polyarteritis nodosa . J Rheumatol 1982;;9:441-442.
13 +
Pope A, Lazarchick J, Hoyer L, et al:  Hairy cell leukemia and vasculitis . J Rheumatol 1980;;7:895-899.
14 +
Dorsey JK, Penick GD:  The association of hairy cell leukemia with unusual immunologic disorders . Arch Intern Med 1982;; 142:902-903.
15 +
Anuras S, McMahon BJ, Chow KC, et al:  Severe abdominal vasculitis with hepatitis B antigenemia . Am J Surg 1980;;140:692-695.
16 +
Rudolph RI:  Vasculitis associated with hairy cell leukemia . Arch Dermatol 1980;;116:1077-1078.
17 +
Kenny PGW, Shum DT, Smout MS:  Leukocytoclastic vasculitis in hairy cell leukemia (leukemic reticuloendotheliosis) . Arch Dermatol 1983;;119:1018-1019.
18 +
Raju SF, Chapman SW, Dreiling B, et al:  Hairy cell leukemia with the appearance of mixed cryoglobulinemia and vasculitis . Arch Intern Med 1984;;144:1300-1302.
19 +
Finan MC, Su WPD, Li C-Y:  Cutaneous findings in hairy cell leukemia . J Am Acad Dermatol 1984;;11:788-797.
20 +
Curth HO:  Skin lesions and internal carcinoma , in Andrade R, Gumport SL, Papkin GL, et al (eds): Cancer of the Skin. Philadelphia, WB Saunders Co, 1976;, pp 1308-1343.
21 +
Hawley PR, Johnston AW, Rankin JT:  Association between digital ischemia and malignant disease . Br Med J 1967;;3:208-212.
22 +
Cupps TR, Fauci AS:  Vasculitis and neoplasm , in The Vasculitides. Philadelphia, WB Saunders Co, 1981;, pp 116-122.
23 +
Stahl RL, Silber R:  Vasculitic leg ulcers in chronic myelogenous leukemia . Am J Med 1985;;78:869-872.
24 +
Sams WM Jr, Harville DD, Winkelmann RK:  Necrotizing vasculitis with lethal reticuloendothelial disease . Br J Dermatol 1968;;80:555-560.
25 +
Garcias VA, Herr HW:  Henoch-Schönlein purpura associated with cancer of prostate . Urology 1982;;19:155-158.
26 +
Spiers ASD, Parekh SJ, Bishop MB:  Hairy cell leukemia: Induction of complete remission with pentostatin (2′-deoxycoformycin) . J Clin Oncol 1984;;2:1336-1342.

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1 +
Turner A, Kjeldsberg CR:  Hairy cell leukemia: A review . Medicine 1978;;57:477-499.
2 +
Bouroncle BA, Wiseman BK, Doan CA:  Leukemic reticuloendotheliosis . Blood 1958;;13:609-630.
3 +
Schrek R, Donnelly WJ:  `Hairy cells' in blood in lymphoreticular neoplastic disease and 'flagellated' cells of normal lymph nodes . Blood 1966;;27:199-211.
4 +
Yam LT, Li C-Y, Finkel HE:  Leukemia reticuloendotheliosis . Arch Intern Med 1972;;130:248-256.
5 +
Lusch CJ, Ramsey HE, Katayam AI:  Leukemic reticuloendotheliosis: Report of a case with peripheral blood remission on androgen therapy . Cancer 1978;;41:1964-1966.
6 +
Golomb HM, Catovsky D, Golde DW:  Hairy cell leukemia: A clinical review based on 71 cases . Ann Intern Med 1978;;89:677-683.
7 +
Westbrook CA, Groopman JE, Golde DW:  Hairy cell leukemia: Disease pattern and prognosis . Cancer 1984;;54:500-506.
8 +
Bouroncle BA:  Leukemic reticuloendotheliosis (hairy cell leukemia) . Blood 1979;;53:412-436.
9 +
Hughes GRV, Elkon KB, Spiller R, et al:  Polyarteritis nodosa and hairy cell leukemia . Lancet 1979;;1:;678.
10 +
Elkon KB, Hughes GRV, Catovsky D, et al:  Hairy cell leukemia with polyarteritis nodosa . Lancet 1979;;2:280-282.
11 +
Goedert JJ, Neete JR, Smith FS, et al:  Polyarteritis nodosa, hairy cell leukemia and splenosis . Am J Med 1981;;71:323-326.
12 +
LePogamp P, Ghandour C, LePrise PY:  Hairy cell leukemia and polyarteritis nodosa . J Rheumatol 1982;;9:441-442.
13 +
Pope A, Lazarchick J, Hoyer L, et al:  Hairy cell leukemia and vasculitis . J Rheumatol 1980;;7:895-899.
14 +
Dorsey JK, Penick GD:  The association of hairy cell leukemia with unusual immunologic disorders . Arch Intern Med 1982;; 142:902-903.
15 +
Anuras S, McMahon BJ, Chow KC, et al:  Severe abdominal vasculitis with hepatitis B antigenemia . Am J Surg 1980;;140:692-695.
16 +
Rudolph RI:  Vasculitis associated with hairy cell leukemia . Arch Dermatol 1980;;116:1077-1078.
17 +
Kenny PGW, Shum DT, Smout MS:  Leukocytoclastic vasculitis in hairy cell leukemia (leukemic reticuloendotheliosis) . Arch Dermatol 1983;;119:1018-1019.
18 +
Raju SF, Chapman SW, Dreiling B, et al:  Hairy cell leukemia with the appearance of mixed cryoglobulinemia and vasculitis . Arch Intern Med 1984;;144:1300-1302.
19 +
Finan MC, Su WPD, Li C-Y:  Cutaneous findings in hairy cell leukemia . J Am Acad Dermatol 1984;;11:788-797.
20 +
Curth HO:  Skin lesions and internal carcinoma , in Andrade R, Gumport SL, Papkin GL, et al (eds): Cancer of the Skin. Philadelphia, WB Saunders Co, 1976;, pp 1308-1343.
21 +
Hawley PR, Johnston AW, Rankin JT:  Association between digital ischemia and malignant disease . Br Med J 1967;;3:208-212.
22 +
Cupps TR, Fauci AS:  Vasculitis and neoplasm , in The Vasculitides. Philadelphia, WB Saunders Co, 1981;, pp 116-122.
23 +
Stahl RL, Silber R:  Vasculitic leg ulcers in chronic myelogenous leukemia . Am J Med 1985;;78:869-872.
24 +
Sams WM Jr, Harville DD, Winkelmann RK:  Necrotizing vasculitis with lethal reticuloendothelial disease . Br J Dermatol 1968;;80:555-560.
25 +
Garcias VA, Herr HW:  Henoch-Schönlein purpura associated with cancer of prostate . Urology 1982;;19:155-158.
26 +
Spiers ASD, Parekh SJ, Bishop MB:  Hairy cell leukemia: Induction of complete remission with pentostatin (2′-deoxycoformycin) . J Clin Oncol 1984;;2:1336-1342.

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