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Topical Antiandrogens: Title and subTitle BreakWhat Use in Dermatology?

Anne W. Lucky, MD
Arch Dermatol. 1985;121(1):55-56. doi:10.1001/archderm.1985.01660010059018
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The interaction between androgenic hormones and the skin has been a fascinating area of research that has tantalized dermatologists for several decades. Hirsutism, balding, and acne are all androgen-related disorders. Elevated levels of circulating androgens have recently been discovered in at least 80% of women suffering from hirsutism1 and, to a lesser extent, in women with female-pattern hair loss and acne.2 However, some obvious questions persist: Why does androgen cause hair to grow in some areas, such as the face, but cause it to regress to vellus hairs in other areas, such as the scalp? Why, with similar degrees of hyperandrogenemia, does severe acne develop in one woman and hirsutism in another? Answers to these questions seem to lie within the skin itself. An understanding of the response of the skin and its appendages to circulating hormones requires innovative research. We would all like to see a topical

REFERENCES

Hatch R, Rosenfield RL, Kim MH, et al:  Hirsutism: Implications, etiology, and management . Am J Obstet Gynecol 1981;; 140:815-830.
Lucky AW, McGuire JS, Rosenfield RL, et al:  Plasma androgens in women with acne vulgaris . J Invest Dermatol 1983;;81:70-74.
Stewart ME, Pochi PE:  Antiandrogens and the skin . Int J Dermatol 1978;;17:167-179.
Hamilton JB, Montagna W:  The sebaceous glands of the hamster: I. Morphological effects of androgens on integumentary structures . Am J Anat 1950;;86:191-233.
Vermorken AJM, Goos CMAA, Wirtz P:  Evaluation of the hamster flank organ test for the screening of anti-androgens . Br J Dermatol 1982;;106:99-101.
Weissmann A, Bowden J, Frank BL, et al:  Antiandrogenic effects of topically spironolactone on the hamster flank organ . Arch Dermatol 1985;;121:57-62.
Luderschmidt C, Bidlingmaier F, Plewig G:  Inhibition of sebaceous gland activity by spironolactone in Syrian hamster . J Invest Dermatol 1982;;78:253-255.
Shapiro G, Evron S:  A novel use of spironolactone: Treatment of hirsutism . J Clin Endocrinol Metabol 1980;;51:429-432.
Cumming DC, Yang JC, Rebar RW, et al:  Treatment of hirsutism with spironolactone . JAMA 1982;;247:1295-1298.
Kaszynski E:  The stimulation of hair growth in the flank organs of female hamsters by subcutaneous testosterone propionate and its inhibition by topical cyproterone acetate: Doseresponse studies . Br J Dermatol 1983;;109:565-569.
Vermorken AJM, Goos CMAA, Roelofs HMJ:  The antiandrogenic effect of progesterone on the hamster flank organ . Br J Dermatol 1980;;102:455-460.
Vermorken AJM, Goos CMAA, Roelofs HMJ:  A method for the evaluation of the local antiandrogenic action of 5alphareductase inhibitors on human skin . Br J Dermatol 1980;;102:695-701.

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Hatch R, Rosenfield RL, Kim MH, et al:  Hirsutism: Implications, etiology, and management . Am J Obstet Gynecol 1981;; 140:815-830.
Lucky AW, McGuire JS, Rosenfield RL, et al:  Plasma androgens in women with acne vulgaris . J Invest Dermatol 1983;;81:70-74.
Stewart ME, Pochi PE:  Antiandrogens and the skin . Int J Dermatol 1978;;17:167-179.
Hamilton JB, Montagna W:  The sebaceous glands of the hamster: I. Morphological effects of androgens on integumentary structures . Am J Anat 1950;;86:191-233.
Vermorken AJM, Goos CMAA, Wirtz P:  Evaluation of the hamster flank organ test for the screening of anti-androgens . Br J Dermatol 1982;;106:99-101.
Weissmann A, Bowden J, Frank BL, et al:  Antiandrogenic effects of topically spironolactone on the hamster flank organ . Arch Dermatol 1985;;121:57-62.
Luderschmidt C, Bidlingmaier F, Plewig G:  Inhibition of sebaceous gland activity by spironolactone in Syrian hamster . J Invest Dermatol 1982;;78:253-255.
Shapiro G, Evron S:  A novel use of spironolactone: Treatment of hirsutism . J Clin Endocrinol Metabol 1980;;51:429-432.
Cumming DC, Yang JC, Rebar RW, et al:  Treatment of hirsutism with spironolactone . JAMA 1982;;247:1295-1298.
Kaszynski E:  The stimulation of hair growth in the flank organs of female hamsters by subcutaneous testosterone propionate and its inhibition by topical cyproterone acetate: Doseresponse studies . Br J Dermatol 1983;;109:565-569.
Vermorken AJM, Goos CMAA, Roelofs HMJ:  The antiandrogenic effect of progesterone on the hamster flank organ . Br J Dermatol 1980;;102:455-460.
Vermorken AJM, Goos CMAA, Roelofs HMJ:  A method for the evaluation of the local antiandrogenic action of 5alphareductase inhibitors on human skin . Br J Dermatol 1980;;102:695-701.

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