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January 1985, Vol 121, No. 1 >
Article | January 1985

Increased Natural Killer Cell Activity in Patients With Epidermodysplasia Verruciformis

Marek Kamiński, MD; Maria Pawińska, MD; Stefania Jablonska, MD; Andrzej Szmurło, MD; Sławomir Majewski, MD; Gerard Orth, MD
[+] Author Affiliations

Accepted for publication April 19, 1984.

Reprint requests to Department of Dermatology, Warsaw School of Medicine, 02-008 Warszawa, Koszykowa 82A, Poland (Dr Kamiński).


From the Departments of Dermatology (Drs Kaminski, Pawińska, Jablonska, and Majewski) and Histology (Drs Kamiński, Szmurło, and Majewski), Warsaw School of Medicine; and the Department of Virology, Institut Pasteur, Paris (Dr Orth).


Arch Dermatol. 1985;121(1):84-86. doi:10.1001/archderm.1985.01660010088025
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• Six patients with epidermodysplasia verruciformis (EV) were studied for natural killer cell (NKC) cytotoxic response of their peripheral blood mononuclear cells against K-562 target cells in an 18-hour chromium 51-release assay. Four patients displayed higher cytotoxic responses than controls did, whereas two others did not differ from controls. Patients with EV who had increased NKC activity were found to be infected with potentially oncogenic human papillomaviruses (types 5, 8, 9, 14, 17, 19, 22, 24, and others), and they have had multiple skin carcinomas and/or Bowen's precancerous dermatosis. Two patients with EV who had normal cytotoxic response were free of skin malignancies.

(Arch Dermatol 1985;121:84-86)

REFERENCES

1 +
Orth G, Jabłońska S, Favre M, et al:  Characterization of two types of human papillomaviruses in lesions of epidermodysplasia verruciformis . Proc Natl Acad Sci USA 1978;;75:1537-1541.
2 +
Orth G, Favre M, Breitburd F, et al:  Epidermodysplasia verruciformis: A model for the role of papillomaviruses in human cancer , in Essex M, Todaro M, zur Hausen H (eds): Virus in Naturally Occurring Cancers . Cold Spring Harbor, NY, Cold Spring Harbor Laboratory, 1980;, vol A, pp 259-282.
3 +
Jablonska S, Da̧browski J, Jakubowicz K:  Epidermodysplasia verruciformis as a model in studies on the role of papovaviruses in oncogenesis . Cancer Res 1972;;32:583-589.
4 +
Glinski W, Jablonska S, Langner A, et al:  Cell mediated immunity in epidermodysplasia verruciformis . Dermatologica 1976;;153:218-227.
5 +
Gliński W, Obalek S, Jabłońska S, et al:  T-cell defect in patients with epidermodysplasia verruciformis due to human papillomavirus type 3 and 5 . Dermatologica 1981;;162:141-147.
6 +
Prawer SE, Pass F, Vance J, et al:  Depressed immune function in epidermodysplasia verruciformis . Arch Dermatol 1977;;113:495-499.
7 +
Claudy AL, Touraine JL, Mitanne A:  Epidermodysplasia verruciformis induced by a new human papillomavirus (HPV-8) . Arch Dermatol Res 1982;;274:213-219.
8 +
Jabłońska S, Orth G, Lutzner MA:  Immunopathology of papillomavirus-induced tumors in different tissues . Semin Immunopathol 1982;;5:33-62.
9 +
Roder JC, Pross HF:  The biology of the human natural killer cell . J Clin Immunol 1982;;2:249-263.
10 +
Goldfarb RH, Herberman RB:  Characteristics of natural killer cells as possible mechanisms for their cytotoxic activity , in: Weissman G (ed): Advances in Inflammation Research . New York, Raven Press, 1982;, vol 4, pp 45-72.
11 +
Tilden AB, Abo T, Balck CM:  Suppressor cell function of human granular lymphocytes identified by the HNK-1 (Leu 7) monoclonal antibody . J Immunol 1983;;130:1171-1175.
12 +
Bloom N, Minato N, Neighbour A, et al:  Interferon and NK cells in resistance of persistently virus-infected cells and tumors , in Herberman RB (ed): Natural Cell-Mediated Immunity Against Tumors . New York, Academic Press Inc, 1980;, pp 505-524.
13 +
Flad HD, Betzler M, Scholz W, et al:  Modulation of NK cell activity in patients with solid malignancies by surgical tumor reduction and fibroblast interferon . Human Cancer Immunol 1982;;4:115-204.
14 +
Orth G, Jablonska S, Obałek S, et al:  Epidermodysplasia verruciformis (EV): A rare and puzzling disease . Read before the European Molecular Biology Organization Workshop on Papillomaviruses, Örenas, Sweden, July 27-30, 1983 .
15 +
Kremsdorf D, Jablonska S, Favre M, et al:  Biochemical characterization of two types of human papillomaviruses associated with epidermodysplasia verruciformis . J Virol 1982;;43:436-447.
16 +
Kremsdorf D, Jablonska S, Favre M, et al:  Human papillomaviruses associated with epidermodysplasia verruciformis: II. Molecular cloning and biochemical characterization of HPV-3a, HPV-8, and HPV-12 genomes . J Virol 1983;.
17 +
Jablonska S, Orth G, Jarza̧bek-Chorzelska M, et al:  Epidermodysplasia verruciformis versus disseminated verrucae planae: Is epidermodysplasia verruciformis a generalized infection with wart virus? J Invest Dermatol 1979;;72:114-119.
18 +
Tsokos GC, Rook AH, Djeu JY, et al:  Natural killer cells and interferon response in patients with systemic lupus erythematosus . Clin Exp Immunol 1982;;50:239-245.
19 +
Katz P, Zaytoun AM, Lee JH Jr, et al:  Abnormal natural killer cell activity in systemic lupus erythematosus: An intrinsic defect in the lytic event . J Immunol 1982;;129:1966-1971.
20 +
Kamiński MJ, Nowaczyk M, Skopińska-Różewska E, et al:  Human peripheral blood lymphocyte subpopulations isolated on the basis of their affinity for SRBC differ in angiogenesis-inducing capability . Clin Exp Immunol 1981;;46:237-331.
21 +
Kozlowski S, Hirsen DJ, Jackson EJ:  Comparison of natural killing with antibody dependent cell mediated cytotoxicity in patients with systemic lupus erythematosus . J Rheumatol 1982;; 9:59-62.
22 +
Huddlestone JR, Meringan TC, Oldstone MBA:  Induction and kinetics of natural killer cells in humans . Nature 1979;;282:417.
23 +
Einhorn S:  Enhancement of human NK activity by interferon: In vivo and in vitro studies , in Herberman RB (ed): Natural Cell-Mediated Immunity Against Tumors . New York, Academic Press Inc, 1980;, p 529.
24 +
Orth G, Jablonska S, Jarzabek-Chorzelska M, et al:  Characteristics of the lesions and risk of malignant conversion associated with the type of human papillomavirus involvement in epidermodysplasia verruciformis . Cancer Res 1979;;39:1074-1082.
25 +
Herberman RB (ed): Natural Cell-Mediated Immunity Against Tumors . New York, Academic Press Inc, 1980;.

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1 +
Orth G, Jabłońska S, Favre M, et al:  Characterization of two types of human papillomaviruses in lesions of epidermodysplasia verruciformis . Proc Natl Acad Sci USA 1978;;75:1537-1541.
2 +
Orth G, Favre M, Breitburd F, et al:  Epidermodysplasia verruciformis: A model for the role of papillomaviruses in human cancer , in Essex M, Todaro M, zur Hausen H (eds): Virus in Naturally Occurring Cancers . Cold Spring Harbor, NY, Cold Spring Harbor Laboratory, 1980;, vol A, pp 259-282.
3 +
Jablonska S, Da̧browski J, Jakubowicz K:  Epidermodysplasia verruciformis as a model in studies on the role of papovaviruses in oncogenesis . Cancer Res 1972;;32:583-589.
4 +
Glinski W, Jablonska S, Langner A, et al:  Cell mediated immunity in epidermodysplasia verruciformis . Dermatologica 1976;;153:218-227.
5 +
Gliński W, Obalek S, Jabłońska S, et al:  T-cell defect in patients with epidermodysplasia verruciformis due to human papillomavirus type 3 and 5 . Dermatologica 1981;;162:141-147.
6 +
Prawer SE, Pass F, Vance J, et al:  Depressed immune function in epidermodysplasia verruciformis . Arch Dermatol 1977;;113:495-499.
7 +
Claudy AL, Touraine JL, Mitanne A:  Epidermodysplasia verruciformis induced by a new human papillomavirus (HPV-8) . Arch Dermatol Res 1982;;274:213-219.
8 +
Jabłońska S, Orth G, Lutzner MA:  Immunopathology of papillomavirus-induced tumors in different tissues . Semin Immunopathol 1982;;5:33-62.
9 +
Roder JC, Pross HF:  The biology of the human natural killer cell . J Clin Immunol 1982;;2:249-263.
10 +
Goldfarb RH, Herberman RB:  Characteristics of natural killer cells as possible mechanisms for their cytotoxic activity , in: Weissman G (ed): Advances in Inflammation Research . New York, Raven Press, 1982;, vol 4, pp 45-72.
11 +
Tilden AB, Abo T, Balck CM:  Suppressor cell function of human granular lymphocytes identified by the HNK-1 (Leu 7) monoclonal antibody . J Immunol 1983;;130:1171-1175.
12 +
Bloom N, Minato N, Neighbour A, et al:  Interferon and NK cells in resistance of persistently virus-infected cells and tumors , in Herberman RB (ed): Natural Cell-Mediated Immunity Against Tumors . New York, Academic Press Inc, 1980;, pp 505-524.
13 +
Flad HD, Betzler M, Scholz W, et al:  Modulation of NK cell activity in patients with solid malignancies by surgical tumor reduction and fibroblast interferon . Human Cancer Immunol 1982;;4:115-204.
14 +
Orth G, Jablonska S, Obałek S, et al:  Epidermodysplasia verruciformis (EV): A rare and puzzling disease . Read before the European Molecular Biology Organization Workshop on Papillomaviruses, Örenas, Sweden, July 27-30, 1983 .
15 +
Kremsdorf D, Jablonska S, Favre M, et al:  Biochemical characterization of two types of human papillomaviruses associated with epidermodysplasia verruciformis . J Virol 1982;;43:436-447.
16 +
Kremsdorf D, Jablonska S, Favre M, et al:  Human papillomaviruses associated with epidermodysplasia verruciformis: II. Molecular cloning and biochemical characterization of HPV-3a, HPV-8, and HPV-12 genomes . J Virol 1983;.
17 +
Jablonska S, Orth G, Jarza̧bek-Chorzelska M, et al:  Epidermodysplasia verruciformis versus disseminated verrucae planae: Is epidermodysplasia verruciformis a generalized infection with wart virus? J Invest Dermatol 1979;;72:114-119.
18 +
Tsokos GC, Rook AH, Djeu JY, et al:  Natural killer cells and interferon response in patients with systemic lupus erythematosus . Clin Exp Immunol 1982;;50:239-245.
19 +
Katz P, Zaytoun AM, Lee JH Jr, et al:  Abnormal natural killer cell activity in systemic lupus erythematosus: An intrinsic defect in the lytic event . J Immunol 1982;;129:1966-1971.
20 +
Kamiński MJ, Nowaczyk M, Skopińska-Różewska E, et al:  Human peripheral blood lymphocyte subpopulations isolated on the basis of their affinity for SRBC differ in angiogenesis-inducing capability . Clin Exp Immunol 1981;;46:237-331.
21 +
Kozlowski S, Hirsen DJ, Jackson EJ:  Comparison of natural killing with antibody dependent cell mediated cytotoxicity in patients with systemic lupus erythematosus . J Rheumatol 1982;; 9:59-62.
22 +
Huddlestone JR, Meringan TC, Oldstone MBA:  Induction and kinetics of natural killer cells in humans . Nature 1979;;282:417.
23 +
Einhorn S:  Enhancement of human NK activity by interferon: In vivo and in vitro studies , in Herberman RB (ed): Natural Cell-Mediated Immunity Against Tumors . New York, Academic Press Inc, 1980;, p 529.
24 +
Orth G, Jablonska S, Jarzabek-Chorzelska M, et al:  Characteristics of the lesions and risk of malignant conversion associated with the type of human papillomavirus involvement in epidermodysplasia verruciformis . Cancer Res 1979;;39:1074-1082.
25 +
Herberman RB (ed): Natural Cell-Mediated Immunity Against Tumors . New York, Academic Press Inc, 1980;.

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