0
January 1982, Vol 118, No. 1 >
Article | January 1982

Vitiligo: Title and subTitle BreakIt Is Important

James J. Nordlund, MD; Aaron B. Lerner, MD
[+] Author Affiliations

West Haven, Conn; New Haven, Conn


Arch Dermatol. 1982;118(1):5-8. doi:10.1001/archderm.1982.01650130009007
Text Size: A A A
Published online
Article
References
Comments

Vitiligo is a disorder that affects 1 to 2 million Americans.1 The obvious manifestations are asymptomatic white spots on the skin. However, often the eyes and, at times, the leptomeninges may be involved. In addition, numerous disorders may be associated with vitiligo. Treatment of the loss of pigment in the skin is prolonged, difficult, and requires a sustained effort by the patient and the physician. Most physicians incorrectly advise their patients that there is little hope or need to treat the condition. That advice is well-meaning but misguided and discouraging for the patient. The cosmetic disfigurement has a substantial impact on a person's social and professional relationships.2

Vitiligo is caused by the destruction of pigment cells. Vitiligo develops in half of the patients it affects before the age of 18 years and in one fourth of the patients before the age of 8 years. Depigmentation begins most frequently

REFERENCES

1 +
Lerner AB, Nordlund JJ:  Vitiligo: What is it? Is it important? JAMA 1978;;239:1183-1187.
2 +
Porter J, Beuf AH, Nordlund JJ, et al:  Psychological reaction to chronic skin disorders: A study of patients with vitiligo . Gen Hosp Psychiatry 1979;;1:73-77.
3 +
Nordlund JJ, Lerner AB:  Vitiligo , in Demis DJ, Crounse R, Dobson RL, et al (eds): Clinical Dermatology . Hagerstown, Md, Harper & Row Publishers Inc, 1979;, vol 2, pp 1-14.
4 +
Moellmann G, Scollay D, Klein-Angerer S, et al:  Intercellular particulate material and degeneration of keratinocytes in the clinically normal epidermis of patients with vitiligo , abstracted. J Invest Dermatol 1981;;76:321.
5 +
Nordlund JJ, Lerner AB:  Vitiligo: Its relationship to systemic disease , in Moschella SL (ed): Dermatology Update . New York, Elsevier North Holland Inc, 1979;, pp 411-432.
6 +
James O, Mayes RW, Stevenson CJ:  Occupational vitiligo induced by p-tert-butylphenol, a systemic disease? Lancet 1977;;2:1217-1219.
7 +
Pawelek J, Lerner AB:  5,6-Dihydroxyindole is a melanin precursor showing potent cytotoxicity . Nature 1978;;276:627-628.
8 +
Chin YM, Chavin W:  Effects of depigmentary agents and related compounds upon in vitro tyrosinase activity , in Riley V (ed): Pigmentation . New York, Appleton-Century-Crofts, 1972;, pp 593-606.
9 +
Koga M:  Vitiligo: A new classification and therapy . Br J Dermatol 1977;;97:255-261.
10 +
Chanco-Turner ML, Lerner AB:  Physiologic changes in vitiligo . Arch Dermatol 1965;;91:390-396.
11 +
Addison T: Constitutional and Local Effects of Disease of the Suprarenal Capsule . London, Samuel Highly Co, 1855;, plates X-XI.
12 +
Walters TR, Lerner AB, Nordlund JJ:  Vitiligo, chronic thrombocytopenia, and autoimmune hemolytic anemia . Arch Dermatol 1978;;114:1366-1367.
13 +
Hertz KC, Gazze LA, Kirkpatrick CH, et al: Autoimmune vitiligo:  Detection of antibodies to melanin-producing cells . N Engl J Med 1977;; 297:634-637.
14 +
Nordlund JJ, Howanitz N, Bystryn JC, et al:  Anti-pigment-cell factors and mucocutaneous candidiasis . Arch Dermatol 1981;;117:210-212.
15 +
Howanitz N, Nordlund JJ, Lerner AB, et al:  Antibodies to melanocytes: Occurrence in patients with vitiligo and chronic mucocutaneous candidiasis . Arch Dermatol 1981;;117:705-708.
16 +
Albert DM, Nordlund JJ, Lerner AB:  Ocular abnormalities occurring with vitiligo . Ophthalmology 1979;;86:1145-1160.
17 +
Nordlund JJ, Todes-Taylor N, Albert DM, et al:  Prevalence of vitiligo and poliosis in patients with uveitis . J Am Acad Dermatol 1981;;4:528-537.
18 +
Lerner AB, Nordlund JJ:  Vitiligo: Loss of pigment in skin, hair, and eyes . Nippon Hifuka Gakkai Zasshi 1978;;5:1-8.
19 +
Millikan LE, Hook RR, Manning PJ:  Immunobiology of melanoma: Gross and ultrastructural studies in a new melanoma model: The Sinclair swine . Yale J Biol Med 1973;;46:631-645.
20 +
Lamont SK, Smyth JR:  Effect of bursectomy on development of a spontaneous amelanosis . Clin Immunol Immunopathol , to be published.
21 +
Smyth JR, Boissy RE, Fite KV:  The Dam chicken: A model for spontaneous postnatal cutaneous and ocular amelanosis . J Hered 1981;; 72:150-156.
22 +
Smith K:  Ultraviolet radiation effects on molecules and cells , in Smith KC (ed): Science of Photobiology . New York, Plenum Press Inc, 1977;, pp 113-127.
23 +
Nordlund JJ, Ackles AE, Traynor FF:  The proliferative and toxic effects of ultraviolet light and inflammation on epidermal pigment cells . J Invest Dermatol , to be published.
24 +
Kuehl FA Jr, Egan RW:  Prostaglandins, arachidonic acid, and inflammation . Science 1980;;210:978-984.
25 +
Egan RW, Paxton J, Kuehl FA Jr:  Mechanism for irreversible self-deactivation of prostaglandin synthetase . J Biol Chem 1976;;251:7329-7335.

First Page Preview

First page PDF preview

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Lerner AB, Nordlund JJ:  Vitiligo: What is it? Is it important? JAMA 1978;;239:1183-1187.
2 +
Porter J, Beuf AH, Nordlund JJ, et al:  Psychological reaction to chronic skin disorders: A study of patients with vitiligo . Gen Hosp Psychiatry 1979;;1:73-77.
3 +
Nordlund JJ, Lerner AB:  Vitiligo , in Demis DJ, Crounse R, Dobson RL, et al (eds): Clinical Dermatology . Hagerstown, Md, Harper & Row Publishers Inc, 1979;, vol 2, pp 1-14.
4 +
Moellmann G, Scollay D, Klein-Angerer S, et al:  Intercellular particulate material and degeneration of keratinocytes in the clinically normal epidermis of patients with vitiligo , abstracted. J Invest Dermatol 1981;;76:321.
5 +
Nordlund JJ, Lerner AB:  Vitiligo: Its relationship to systemic disease , in Moschella SL (ed): Dermatology Update . New York, Elsevier North Holland Inc, 1979;, pp 411-432.
6 +
James O, Mayes RW, Stevenson CJ:  Occupational vitiligo induced by p-tert-butylphenol, a systemic disease? Lancet 1977;;2:1217-1219.
7 +
Pawelek J, Lerner AB:  5,6-Dihydroxyindole is a melanin precursor showing potent cytotoxicity . Nature 1978;;276:627-628.
8 +
Chin YM, Chavin W:  Effects of depigmentary agents and related compounds upon in vitro tyrosinase activity , in Riley V (ed): Pigmentation . New York, Appleton-Century-Crofts, 1972;, pp 593-606.
9 +
Koga M:  Vitiligo: A new classification and therapy . Br J Dermatol 1977;;97:255-261.
10 +
Chanco-Turner ML, Lerner AB:  Physiologic changes in vitiligo . Arch Dermatol 1965;;91:390-396.
11 +
Addison T: Constitutional and Local Effects of Disease of the Suprarenal Capsule . London, Samuel Highly Co, 1855;, plates X-XI.
12 +
Walters TR, Lerner AB, Nordlund JJ:  Vitiligo, chronic thrombocytopenia, and autoimmune hemolytic anemia . Arch Dermatol 1978;;114:1366-1367.
13 +
Hertz KC, Gazze LA, Kirkpatrick CH, et al: Autoimmune vitiligo:  Detection of antibodies to melanin-producing cells . N Engl J Med 1977;; 297:634-637.
14 +
Nordlund JJ, Howanitz N, Bystryn JC, et al:  Anti-pigment-cell factors and mucocutaneous candidiasis . Arch Dermatol 1981;;117:210-212.
15 +
Howanitz N, Nordlund JJ, Lerner AB, et al:  Antibodies to melanocytes: Occurrence in patients with vitiligo and chronic mucocutaneous candidiasis . Arch Dermatol 1981;;117:705-708.
16 +
Albert DM, Nordlund JJ, Lerner AB:  Ocular abnormalities occurring with vitiligo . Ophthalmology 1979;;86:1145-1160.
17 +
Nordlund JJ, Todes-Taylor N, Albert DM, et al:  Prevalence of vitiligo and poliosis in patients with uveitis . J Am Acad Dermatol 1981;;4:528-537.
18 +
Lerner AB, Nordlund JJ:  Vitiligo: Loss of pigment in skin, hair, and eyes . Nippon Hifuka Gakkai Zasshi 1978;;5:1-8.
19 +
Millikan LE, Hook RR, Manning PJ:  Immunobiology of melanoma: Gross and ultrastructural studies in a new melanoma model: The Sinclair swine . Yale J Biol Med 1973;;46:631-645.
20 +
Lamont SK, Smyth JR:  Effect of bursectomy on development of a spontaneous amelanosis . Clin Immunol Immunopathol , to be published.
21 +
Smyth JR, Boissy RE, Fite KV:  The Dam chicken: A model for spontaneous postnatal cutaneous and ocular amelanosis . J Hered 1981;; 72:150-156.
22 +
Smith K:  Ultraviolet radiation effects on molecules and cells , in Smith KC (ed): Science of Photobiology . New York, Plenum Press Inc, 1977;, pp 113-127.
23 +
Nordlund JJ, Ackles AE, Traynor FF:  The proliferative and toxic effects of ultraviolet light and inflammation on epidermal pigment cells . J Invest Dermatol , to be published.
24 +
Kuehl FA Jr, Egan RW:  Prostaglandins, arachidonic acid, and inflammation . Science 1980;;210:978-984.
25 +
Egan RW, Paxton J, Kuehl FA Jr:  Mechanism for irreversible self-deactivation of prostaglandin synthetase . J Biol Chem 1976;;251:7329-7335.

Correspondence

Submit a Letter
CME Course for:


You need to register in order to view this quiz.


To understand the clinical management of acute heart failure syndromes.
Accreditation Information The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
To view and print your certificate and access a summary of your CME courses go to My CME.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Comment

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

© 2012 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems