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Efficacy of Minocycline Compared With Tetracycline in Treatment of Acne Vulgaris

Lt Col Charles G. Hubbell, MCLt Col ; Edmund R. Hobbs, MCMaj ; Toivo Rist, MCCol ; John W. White, Jr, MC
[+] Author Affiliations

Accepted for publication Feb 5, 1982.

Reprint requests to Allenmore Medical Center, Suite 116,19th and Union, Tacoma, WA 98405 (Dr Hubbell).


USAF; USAF; USAF; USAF

From Wilford Hall USAF Medical Center, Lackland AFB, Tex. Drs Hubbell and Rist are now in private practice.


Arch Dermatol. 1982;118(12):989-992. doi:10.1001/archderm.1982.01650240033017
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• A double-blind evaluation of the efficacy and safety of minocycline hydrochloride and tetracycline hydrochloride was conducted and completed using 49 patients with Pillsbury grade 2 or grade 3 acne. For six months, half of the patients received minocycline and half received tetracycline. Although the differences between treatment groups were not statistically significant at any evaluation, more patients treated with minocycline reached and maintained a noninflammatory acne status in less time than did patients treated with tetracycline. After six weeks, twice as many patients in the group treated with minocycline had reached noninflammatory status. Side effects reported by 17 patients were equally distributed between treatment groups. No notable abnormalities were observed in the results of blood chemistry studies, hematologic tests, quantitative serum immunoglobulin determinations, or thyroid function tests in 20 of the patients examined.

(Arch Dermatol 1982;118:989-992)

REFERENCES

Andrews CG, Domonkos HN, Post CF:  Treatment of acne vulgaris . JAMA 1951;;146:1107.
Strauss JS:  Antibiotic therapy for acne vulgaris . Arch Dermatol 1975;;111:1563.
Juhlin L, Linden S:  A quantitative evaluation of the effects of oxytetracycline and doxycycline in acne vulgaris . Br J Dermatol 1969;;81:154-158.
Lane P. Williamson DM:  Treatment of acne vulgaris with tetracycline hydrochloride: A double-blind trial with 51 patients . Br Med J 1969;;2:76-79.
Akers WA, Allen AM, Burnett JW, et al:  Systemic antibiotics for treatment of acne vulgaris: Efficacy and safety . Arch Dermatol 1975;;111:1630-1636.
Kligman AM, Mills OH, Leyden JJ:  Acne vulgaris: A treatable disease . Postgrad Med 1974;;55:99-105.
Reisner RM:  Acne vulgaris . Pediatr Clin North Am 1973;; 20:851-864.
 Committee on Drugs of the American Academy of Pediatrics: Current concepts in therapy: The treatment of acne with antibiotics . South Med J 1973;;66:494-496.
Fleigelman MT:  Acne vulgaris: Long-term antibiotic use . J Ky Med Assoc 1973;;71:311-312.
Sauer GC:  Safety of long-term tetracycline therapy for acne . Arch Dermatol 1976;;112:1603-1605.
Becker FT:  Treatment of tetracycline-resistant acne vulgaris . Cutis 1974;;14:610-613.
Cullen SI:  Low-dose minocycline therapy in tetracycline-recalcitrant acne vulgaris . Cutis 1978;;21:101-105.
Cullen SI, Cohan RH:  Minocycline therapy in acne vulgaris . Cutis 1976;;17:1208-1210, 1214.
Gretzinger T:  Minocycline and thyroid function . Arch Dermatol 1977;;113:1302.
Sauer GC:  Suggested sequence of testing for acne patients receiving long-term tetracycline therapy . Arch Dermatol 1977;;113:1303.
Attwood HD, Dennett X:  A black thyroid and minocycline treatment . Br Med J 1976;;2:1109-1110.
Pillsbury DM, Shelley WB, Kligman AM: A Manual of Cutaneous Medicine . Philadelphia, WB Saunders Co, 1961;, pp 273-276.

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Andrews CG, Domonkos HN, Post CF:  Treatment of acne vulgaris . JAMA 1951;;146:1107.
Strauss JS:  Antibiotic therapy for acne vulgaris . Arch Dermatol 1975;;111:1563.
Juhlin L, Linden S:  A quantitative evaluation of the effects of oxytetracycline and doxycycline in acne vulgaris . Br J Dermatol 1969;;81:154-158.
Lane P. Williamson DM:  Treatment of acne vulgaris with tetracycline hydrochloride: A double-blind trial with 51 patients . Br Med J 1969;;2:76-79.
Akers WA, Allen AM, Burnett JW, et al:  Systemic antibiotics for treatment of acne vulgaris: Efficacy and safety . Arch Dermatol 1975;;111:1630-1636.
Kligman AM, Mills OH, Leyden JJ:  Acne vulgaris: A treatable disease . Postgrad Med 1974;;55:99-105.
Reisner RM:  Acne vulgaris . Pediatr Clin North Am 1973;; 20:851-864.
 Committee on Drugs of the American Academy of Pediatrics: Current concepts in therapy: The treatment of acne with antibiotics . South Med J 1973;;66:494-496.
Fleigelman MT:  Acne vulgaris: Long-term antibiotic use . J Ky Med Assoc 1973;;71:311-312.
Sauer GC:  Safety of long-term tetracycline therapy for acne . Arch Dermatol 1976;;112:1603-1605.
Becker FT:  Treatment of tetracycline-resistant acne vulgaris . Cutis 1974;;14:610-613.
Cullen SI:  Low-dose minocycline therapy in tetracycline-recalcitrant acne vulgaris . Cutis 1978;;21:101-105.
Cullen SI, Cohan RH:  Minocycline therapy in acne vulgaris . Cutis 1976;;17:1208-1210, 1214.
Gretzinger T:  Minocycline and thyroid function . Arch Dermatol 1977;;113:1302.
Sauer GC:  Suggested sequence of testing for acne patients receiving long-term tetracycline therapy . Arch Dermatol 1977;;113:1303.
Attwood HD, Dennett X:  A black thyroid and minocycline treatment . Br Med J 1976;;2:1109-1110.
Pillsbury DM, Shelley WB, Kligman AM: A Manual of Cutaneous Medicine . Philadelphia, WB Saunders Co, 1961;, pp 273-276.

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