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Midline Granuloma: Title and subTitle BreakStewart Type

Clifford W. Lober, MD; Robert J. Kaplan, MD; William H. West, MD
[+] Author Affiliations

Accepted for publication April 2, 1981.

Reprint requests to 956 Court Ave, Coleman Building, Room 3-C-13, Memphis, TN 38163 (Dr Lober).


From the Department of Dermatology, University of Tennessee Center for the Health Sciences and Baptist Memorial Hospital, Memphis.


Arch Dermatol. 1982;118(1):52-54. doi:10.1001/archderm.1982.01650130056022
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• A 34-year-old woman had a granulomatous ulceration of the nose that responded to radiation therapy. The limitation of the disease to the nose and the histologic findings were consistent with a diagnosis of midline granuloma, Stewart type. The relationship of midline granuloma to Wegener's granulomatosis is reviewed. In view of the uniform mortality that accompanies untreated midline granuloma, a correct diagnosis must be made so that radiation therapy can be promptly instituted.

(Arch Dermatol 1982;118:52-54)

REFERENCES

Stewart JP:  Progressive lethal granulomatous ulceration of the nose . J Laryngol Otol 1933;;48:657-701.
Fauci AS, Johnson RE, Wolff SM:  Radiation therapy of midline granuloma . Ann Intern Med 1976;;84:140-147.
McBride P:  Photographs of a case of rapid destruction of the nose and face . J Laryngol Otol 1897;;12:64-66.
Woods R:  Observations on malignant granuloma of the nose . Br Med J 1921;;2:65-66.
M'Arthur GAD, Dew HR:  A case of `malignant granuloma of the nose.' J Laryngol Otol 1925;;40:378-380.
Williams HL:  Lethal granulomatous ulceration involving the midline facial tissues . Ann Otol Rhinol Laryngol 1949;;58:1013-1054.
Blatt IM, Seltzer HS, Rubin P, et al:  Fatal granulomatosis of the respiratory tract (lethal midline granuloma—Wegener's granulomatosis) . Arch Otolaryngol 1959;;70:707-757.
Kassel SH, Echevarria RA, Guzzo FP:  Midline malignant reticulosis (so-called lethal midline granuloma) . Cancer 1969;;23:920-935.
Wetmore SJ, Platz CE:  Idiopathic midface lesions . Ann Otol Rhinol Laryngol 1978;;87:60-69.
Wegener F:  Uber generalisierte, septische Gefasserkrankungen . Verh Dtsch Ges Pathol 1936;;29:202.
Wegener F:  Uber eine eigenartige rhinogene Granulomatose mit besonderer Beteiligung des Arteriensystems und der Nieren . Beitr Pathol Anat 1939;;102:36.
Godman GC, Churg J:  Wegener's granulomatosis: Pathology and review of the literature . Arch Pathol 1954;;58:533-550.
Friedmann I:  Midline granuloma . Proc R Soc Med 1964;;57:289-297.
Byrd LJ, Shearn MA, Tu WH:  Relationship of lethal midline granuloma to Wegener's granulomatosis . Arthritis Rheum 1969;;12:247-253.
Spear GS, Walker WG Jr:  Lethal midline granuloma (granuloma gangraenescens) at autopsy . Bull Johns Hopkins Hosp 1956;;99:313-332.
Schechter SL, Bole GG, Walker SE:  Midline granuloma and Wegener's granulomatosis: Clinical and therapeutic considerations . J Rheumatol 1976;;3:241-250.
Kahn RL:  Tissue immunity: Its possible relationship to midline facial granulomatous ulceration . Univ Mich Med Bull 1954;;20:208-218.
 `Midline granuloma': A diagnosis best forgotten?  editorial. Clin Otolaryngol Allied Sci 1978;;3:68-69.
 Non-healing (midline) granuloma , editorial. Lancet 1977;;1:1296-1297.
Dickson RJ:  Radiotherapy of lethal mid-line granuloma . J Chronic Dis 1960;;12:417-427.

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Stewart JP:  Progressive lethal granulomatous ulceration of the nose . J Laryngol Otol 1933;;48:657-701.
Fauci AS, Johnson RE, Wolff SM:  Radiation therapy of midline granuloma . Ann Intern Med 1976;;84:140-147.
McBride P:  Photographs of a case of rapid destruction of the nose and face . J Laryngol Otol 1897;;12:64-66.
Woods R:  Observations on malignant granuloma of the nose . Br Med J 1921;;2:65-66.
M'Arthur GAD, Dew HR:  A case of `malignant granuloma of the nose.' J Laryngol Otol 1925;;40:378-380.
Williams HL:  Lethal granulomatous ulceration involving the midline facial tissues . Ann Otol Rhinol Laryngol 1949;;58:1013-1054.
Blatt IM, Seltzer HS, Rubin P, et al:  Fatal granulomatosis of the respiratory tract (lethal midline granuloma—Wegener's granulomatosis) . Arch Otolaryngol 1959;;70:707-757.
Kassel SH, Echevarria RA, Guzzo FP:  Midline malignant reticulosis (so-called lethal midline granuloma) . Cancer 1969;;23:920-935.
Wetmore SJ, Platz CE:  Idiopathic midface lesions . Ann Otol Rhinol Laryngol 1978;;87:60-69.
Wegener F:  Uber generalisierte, septische Gefasserkrankungen . Verh Dtsch Ges Pathol 1936;;29:202.
Wegener F:  Uber eine eigenartige rhinogene Granulomatose mit besonderer Beteiligung des Arteriensystems und der Nieren . Beitr Pathol Anat 1939;;102:36.
Godman GC, Churg J:  Wegener's granulomatosis: Pathology and review of the literature . Arch Pathol 1954;;58:533-550.
Friedmann I:  Midline granuloma . Proc R Soc Med 1964;;57:289-297.
Byrd LJ, Shearn MA, Tu WH:  Relationship of lethal midline granuloma to Wegener's granulomatosis . Arthritis Rheum 1969;;12:247-253.
Spear GS, Walker WG Jr:  Lethal midline granuloma (granuloma gangraenescens) at autopsy . Bull Johns Hopkins Hosp 1956;;99:313-332.
Schechter SL, Bole GG, Walker SE:  Midline granuloma and Wegener's granulomatosis: Clinical and therapeutic considerations . J Rheumatol 1976;;3:241-250.
Kahn RL:  Tissue immunity: Its possible relationship to midline facial granulomatous ulceration . Univ Mich Med Bull 1954;;20:208-218.
 `Midline granuloma': A diagnosis best forgotten?  editorial. Clin Otolaryngol Allied Sci 1978;;3:68-69.
 Non-healing (midline) granuloma , editorial. Lancet 1977;;1:1296-1297.
Dickson RJ:  Radiotherapy of lethal mid-line granuloma . J Chronic Dis 1960;;12:417-427.

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