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April 1981, Vol 117, No. 4 >
Article | April 1981

Urticaria Induced by Cyclamate

Masuko Fujita, MD; Toshiyuki Aoki, MD
[+] Author Affiliations

Reprint requests to Department of Dermatology, Habikino Hospital of Osaka Prefecture, Habikino-3-7-1, Habikino, Osaka 583, Japan (Dr Fujita).


From the Department of Dermatology, Habikino Hospital of Osaka (Japan) Prefecture.


Arch Dermatol. 1981;117(4):246-246. doi:10.1001/archderm.1981.01650040062027
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Cyclamate sodium has been reported to induce photosensitivity1-3 and, in rats, cancer of the urinary bladder.4 However, to the best of our knowledge, there have been no reports in the literature of urticaria induced by this chemical. We report herein such a case.

Report of a Case  A 63-year-old woman was referred to our hospital because of a ten-year history of almost daily chronic urticaria. Occasionally, associated symptoms included headaches, a prickling sensation in the eyes, dyspnea, abdominal pain, and a tendency to diarrhea. These symptoms were controlled with antihistamines, but recurred immediately when medication was stopped. She had had no personal or family history of atopy. Intradermal skin test results for 43 inhalant and food allergens had been negative. During the course of her urticaria, there had been one occasion on which she was away from home for several days. During her travels, she had had no

REFERENCES

1 +
Kobori T, Araki H:  Photoallergy in dermatology . J Asthma Res 1966;;3:213-215.
2 +
Lamberg SI:  A new photosensitizer, the artificial sweetener, cyclamate . JAMA 1967;;201:747-750.
3 +
Yong JM, and Sanderson KV:  Photosensitive dermatitis and renal tubular acidosis after ingestion of calcium cyclamate . Lancet 1969;;2:1273-1275.
4 +
Price JM, Biava CG, Oser BL, et al:  Bladder tumors in rats fed cyclohexylamine or high doses of a mixture of cyclamate and saccharin . Science 1970;;167:1131-1132.
5 +
 Why cyclamates were banned . Lancet 1970;;1:1091-1092.
6 +
Bazell RJ:  Cyclamate: House report charges administrative alchemy at HEW . Science 1970;;170:419-420.

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1 +
Kobori T, Araki H:  Photoallergy in dermatology . J Asthma Res 1966;;3:213-215.
2 +
Lamberg SI:  A new photosensitizer, the artificial sweetener, cyclamate . JAMA 1967;;201:747-750.
3 +
Yong JM, and Sanderson KV:  Photosensitive dermatitis and renal tubular acidosis after ingestion of calcium cyclamate . Lancet 1969;;2:1273-1275.
4 +
Price JM, Biava CG, Oser BL, et al:  Bladder tumors in rats fed cyclohexylamine or high doses of a mixture of cyclamate and saccharin . Science 1970;;167:1131-1132.
5 +
 Why cyclamates were banned . Lancet 1970;;1:1091-1092.
6 +
Bazell RJ:  Cyclamate: House report charges administrative alchemy at HEW . Science 1970;;170:419-420.

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