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March 1981, Vol 117, No. 3 >
Article | March 1981

Hodgkin's Disease and Granuloma Annulare

Robert Allen Schwartz, MD, MPH; Ronald C. Hansen, MD; Peter J. Lynch, MD
[+] Author Affiliations

Reprint requests to the Department of Dermatology, University of California School of Medicine, 4150 Clement St, San Francisco, CA 94121 (Dr Schwartz).


From the Section of Dermatology, University of Arizona College of Medicine, Tucson (Drs Schwartz, Hansen, and Lynch); and the Department of Dermatology, University of California School of Medicine, San Francisco (Dr Schwartz).


Arch Dermatol. 1981;117(3):185-186. doi:10.1001/archderm.1981.01650030063022
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A recent case of a patient with Hodgkin's disease, seminoma of the testicle, and widespread granuloma annulare (GA) raised the possibility of an association between Hodgkin's disease and GA.1 We describe here two patients with Hodgkin's disease in whom GA developed.

Report of Cases 

Case 1.—  A 57-year-old woman had, in the spring of 1976, a large glandular swelling in the right inguinal area. A biopsy specimen showed Hodgkin's disease of the nodular sclerosing type. Staging evaluation included lymphangiography; abdominal exploration determined that she had stage IIB disease. While undergoing radiotherapy, an enlarged supraclavicular node developed, which, on biopsy, showed the nodular sclerosing pattern. The cancer stage was changed to IIIB. From October 1976 to March 1977, she was treated with intermittent combined chemotherapy (mechlorethamine hydrochloride, vincristine sulfate [Oncovin], procarbazine hydrochloride, and prednisone) (MOPP). She had remained free of evidence of Hodgkin's disease since that time.In September 1979,

REFERENCES

1 +
Harman RRM:  Hodgkin's disease, seminoma of testicle, and widespread granuloma annulare . Br J Dermatol 97( (suppl 15) ):50-51, 1977;.
2 +
Umbert P, Winkelmann RK:  Histologic, ultrastructural, and histochemical studies of granuloma annulare . Arch Dermatol 113:1681-1686, 1977;.
3 +
Dahl MV, Ullman S, Goltz RW:  Vasculitis in granuloma annulare: Histopathology and direct immunofluorescence . Arch Dermatol 113:463-467, 1977;.
4 +
Desforges JF, Rutherford CJ, Piro A:  Hodgkin's disease . N Engl J Med 301:1212-1222, 1979;.
5 +
Brown CA, Hall CL, Long JC, et al:  Circulating immune complexes in Hodgkin's disease . Am J Med 64:289-294, 1978;.
6 +
Heier HE, Carpentier N, Lange G, et al:  Circulating immune complexes in patients with malignant lymphomas and solid tumors . Int J Cancer 20:887-894, 1977;.
7 +
Sams WM Jr, Thorne EG, Small P, et al:  Leukocytoclastic vasculitis . Arch Dermatol 112:219-226, 1976;.

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1 +
Harman RRM:  Hodgkin's disease, seminoma of testicle, and widespread granuloma annulare . Br J Dermatol 97( (suppl 15) ):50-51, 1977;.
2 +
Umbert P, Winkelmann RK:  Histologic, ultrastructural, and histochemical studies of granuloma annulare . Arch Dermatol 113:1681-1686, 1977;.
3 +
Dahl MV, Ullman S, Goltz RW:  Vasculitis in granuloma annulare: Histopathology and direct immunofluorescence . Arch Dermatol 113:463-467, 1977;.
4 +
Desforges JF, Rutherford CJ, Piro A:  Hodgkin's disease . N Engl J Med 301:1212-1222, 1979;.
5 +
Brown CA, Hall CL, Long JC, et al:  Circulating immune complexes in Hodgkin's disease . Am J Med 64:289-294, 1978;.
6 +
Heier HE, Carpentier N, Lange G, et al:  Circulating immune complexes in patients with malignant lymphomas and solid tumors . Int J Cancer 20:887-894, 1977;.
7 +
Sams WM Jr, Thorne EG, Small P, et al:  Leukocytoclastic vasculitis . Arch Dermatol 112:219-226, 1976;.

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