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Intracranial Calcifications and Dyskeratosis Congenita

Stacey E. Mills, MD; Philip H. Cooper, MD; Bruce E. Beacham, MD; Kenneth E. Greer, MD
[+] Author Affiliations

Accepted for publication July 9, 1979.

Reprints not available.


From the Department of Pathology (Drs Mills and Cooper) and the Department of Dermatology (Drs Cooper, Beacham, and Greer), the University of Virginia Medical Center, Charlottesville.


Arch Dermatol. 1979;115(12):1437-1439. doi:10.1001/archderm.1979.04010120035015
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We describe two brothers with dyskeratosis congenita and intracranial calcifications. The calcifications were massive, approximately symmetric, and showed a predilection for the basal ganglia and dentate nuclei. No underlying causes for this finding were identified. Idiopathic familial intracranial calcification of this type has been described, but an association with dyskeratosis congenita has not previously been observed.

(Arch Dermatol 115:1437-1439, 1979)

REFERENCES

Sirinavin C, Trowbridge AA:  Dyskeratosis congenita: clinical features and genetic aspects: Report of a family and review of the literature . J Med Genet 12:339-354, 1975;.
Inoue S, Mekanik G, Mahallati M, et al:  Dyskeratosis congenita with pancytopenia: Another constitutional anemia . Am J Dis Child 126:389-396, 1973;.
Steier W, Van Voolen GA, Selmanowitz VJ:  Dyskeratosis congenita: Relationship to Fanconi's anemia . Blood 39:510-521, 1972;.
Sorrow JM Jr, Hitch JM:  Dyskeratosis congenita: First report of its occurrence in a female and a review of the literature . Arch Dermatol 88:340-347, 1963;.
Bodalski J, Defecinska E, Judkiewicz L, et al:  Fanconi's anemia and dyskeratosis congenita as a syndrome . Dermatologica 127:330-342, 1963;.
Cole HN, Cole HN Jr, Lascheid WP:  Dyskeratosis congenita: Relationship to poikiloderma atrophicans vasculare and to aplastic anemia of Fanconi . Arch Dermatol 76:712-718, 1957;.
Bryan HG, Nixon RK:  Dyskeratosis congenita and familial pancytopenia . JAMA 192:203-208, 1965;.
Gutman A, Frumkin A, Adam A, et al:  X-linked dyskeratosis congenita with pancytopenia . Arch Dermatol 114:1667-1671, 1978;.
Ortega JA, Swanson VL, Landing BH, et al:  Congenital dyskeratosis: Zinsser-Engman-Cole syndrome with thymic dysplasia and aplastic anemia . Am J Dis Child 124:701-704, 1972;.
Löwenthal A, Bruyn GW:  Calcification of the striopallidodentate system , in Vinken PJ, Bruyn GW (eds): Handbook of Clinical Neurology . New York, John Wiley & Sons Inc, 1968;, vol 6, pp 703-725.
Neill CA, Dingwall MM:  A syndrome resembling progeria and a review of two cases . Arch Dis Child 25:213-223, 1950;.

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Sirinavin C, Trowbridge AA:  Dyskeratosis congenita: clinical features and genetic aspects: Report of a family and review of the literature . J Med Genet 12:339-354, 1975;.
Inoue S, Mekanik G, Mahallati M, et al:  Dyskeratosis congenita with pancytopenia: Another constitutional anemia . Am J Dis Child 126:389-396, 1973;.
Steier W, Van Voolen GA, Selmanowitz VJ:  Dyskeratosis congenita: Relationship to Fanconi's anemia . Blood 39:510-521, 1972;.
Sorrow JM Jr, Hitch JM:  Dyskeratosis congenita: First report of its occurrence in a female and a review of the literature . Arch Dermatol 88:340-347, 1963;.
Bodalski J, Defecinska E, Judkiewicz L, et al:  Fanconi's anemia and dyskeratosis congenita as a syndrome . Dermatologica 127:330-342, 1963;.
Cole HN, Cole HN Jr, Lascheid WP:  Dyskeratosis congenita: Relationship to poikiloderma atrophicans vasculare and to aplastic anemia of Fanconi . Arch Dermatol 76:712-718, 1957;.
Bryan HG, Nixon RK:  Dyskeratosis congenita and familial pancytopenia . JAMA 192:203-208, 1965;.
Gutman A, Frumkin A, Adam A, et al:  X-linked dyskeratosis congenita with pancytopenia . Arch Dermatol 114:1667-1671, 1978;.
Ortega JA, Swanson VL, Landing BH, et al:  Congenital dyskeratosis: Zinsser-Engman-Cole syndrome with thymic dysplasia and aplastic anemia . Am J Dis Child 124:701-704, 1972;.
Löwenthal A, Bruyn GW:  Calcification of the striopallidodentate system , in Vinken PJ, Bruyn GW (eds): Handbook of Clinical Neurology . New York, John Wiley & Sons Inc, 1968;, vol 6, pp 703-725.
Neill CA, Dingwall MM:  A syndrome resembling progeria and a review of two cases . Arch Dis Child 25:213-223, 1950;.

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