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December 1976, Vol 112, No. 12 >
Article | December 1976

Thiabendazole-Induced Toxic Epidermal Necrolysis

Harry M. Robinson, Jr, MD; Charles S. Samorodin, MD
[+] Author Affiliations

Accepted for publication Oct 24, 1975.

Reprint requests to Division of Dermatology, University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD 21201 (Dr Robinson).


From the Department of Medicine, Division of Dermatology, University of Maryland School of Medicine, Baltimore.


Arch Dermatol. 1976;112(12):1757-1760. doi:10.1001/archderm.1976.01630370045011
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References
Comments

• Toxic epidermal necrolysis (TEN) is a syndrome that may develop from a number of different stimuli, including drug administration, staphylococcal infection, vaccine administration, and blood dyscrasias. A 29-year-old woman developed TEN from the systemic administration of thiabendazole. Although various cutaneous adverse reactions have been attributed to the administration of this medication, this is the first case to indicate that orally administered thiabendazole may also produce TEN. Although acutely ill at the time of hospitalization, the patient showed a prompt response to treatment with prednisone.

(Arch Dermatol 112:1757-1760, 1976)

REFERENCES

1 +
Lyell A:  Toxic epidermal necrolysis: An eruption resembling scalding of the skin . Br J Dermatol 68:355-361, 1956;.
2 +
Lang R, Walker J:  An unusual bullous eruption . S Arf Med J 30:97-98, 1956;.
3 +
Tyson RG, Ushinski SC, Kisilevsky R:  Toxic epidermal necrolysis (the scalded skin syndrome) . Am J Dis Child 111:386-392, 1966;.
4 +
Jefferson J:  Lyell's toxic epidermal necrolysis: A staphylococcal etiology . Br Med J 2:802-804, 1967;.
5 +
Lowney ED, Banblis JV, Kreye GM, et al:  The scalded skin syndrome in small children . Arch Dermatol 95:359-369, 1967;.
6 +
Koblenzer PJ:  Acute epidermal necrolysis (Ritter von Rittershain-Lyell) . Arch Dermatol 95:608-617, 1967;.
7 +
Ritter von Rittershain C:  Die exfoliative Dermatitis jungerer Sauglinge . Centralzeit Kinderheilkd 2:3-23, 1878;.
8 +
Sloss RG, Rayhanzadeh S:  Toxic epidermal necrolysis following measles vaccination . Arch Dermatol 110:766-770, 1974;.
9 +
Product information circular on thiabendazole. Merck, Sharp and Dohme.
10 +
Brown H:  The chemistry of thiabendazole . Tex Rep Biol Med 27:533-536, 1969;.
11 +
Eaton LG, Siegmund OH, Rankin AO, et al:  The veterinary uses of thiabendazole . Tex Rep Biol Med 27:697-708, 1969;.
12 +
Franz KH:  Clinical trials with thiabendazole against intestinal nematodes infecting humans . Am J Trop Med Hyg 14:383-386, 1965;.
13 +
Most H, Yoeli M, Campbell WC, et al:  The treatment of Strongyloides and Enterobius infection with thiabendazole . Am J Trop Med 14:379-382, 1965;.
14 +
Davis H:  Pinworm infestation-therapy with thiabendazole . Tex Rep Biol Med 27:623-627, 1969;.
15 +
Egerton JR:  The ovicidal and larvicidal effect of thiabendazole on various helminth species . Tex Rep Biol Med 27:561-580, 1969;.
16 +
Kotcher E, Chavarria AP, Gamboa JA, et al:  Community control of intestinal nematodes by thiabendazole treatment . Tex Rep Biol Med 27:629-643, 1969;.
17 +
Chuttani HK, Chouri MAK:  Thiabendazole and related compounds in treatment of hookworm infestation . Tex Rep Biol Med 27:597-600, 1969;.
18 +
Stone OJ:  Systemic and topical thiabendazole for creeping eruption . Tex Rep Biol Med 27:659-663, 1969;.
19 +
Battistini F:  Treatment of creeping eruption with topical thiabendazole . Tex Rep Biol Med 27:644-658, 1969;.
20 +
Hennekeuser HH, Pabst K, Poeplan W, et al:  Thiabendazole for the treatment of trichinosis in humans . Tex Rep Biol Med 27:581-596, 1969;.
21 +
Campbell WC, Cuckler AC:  Thiabendazole in the treatment and control of parasite infections in man . Tex Rep Biol Med 27:665-692, 1969;.
22 +
Franz KH:  Clinical trials of thiabendazole against human strongyloidiasis . Am J Trop Med Hyg 12:211-214, 1963;.
23 +
Salunkhe DS, Gaitorde BB, Vakil BJ:  Clinical evaluation of a new antihelmintic thiabendazole 2-(4′ thiazolyl) benzimidazole . Am J Trop Med 13:412-416, 1964;.
24 +
Stuart JE, Welch JS:  Treatment of trichinosis with thiabendazole . Med J Aust 2:1017-1019, 1973;.
25 +
Robinson HJ, Silber RH, Graessle OE:  Thiabendazole: Toxicological, pharmacological and antifungal properties . Tex Rep Biol Med 27:537-560, 1969;.
26 +
Katz R, Ziegler J, Blank H:  The natural course of creeping eruption and treatment with thiabendazole . Arch Dermatol 91:420-424, 1965;.
27 +
Stone OJ, Mullins JF:  Thiabendazole-effectiveness in creeping eruption . Arch Dermatol 91:427-429, 1965;.
28 +
Huang OH, Brown HSW:  The efficacy of thiabendazole against hookworm and ascaris of man . J Parsitol 49:1014-1018, 1963;.
29 +
Jacksonville Dermatologic Society:  Creeping eruption treatment with thiabendazole . Arch Dermatol 91:425-426, 1965;.
30 +
Kean BH, Hoskins DW:  Treatment of trichinosis with thiabendazole: A preliminary report . JAMA 190:852-853, 1964;.
31 +
Rist TE, Abele DC:  Current concepts of toxic epidermal necrolysis . South Med J 68:22-26, 1975;.
32 +
Radimer GF, Davis JH, Ackerman AB:  Fumigant induced toxic epidermal necrolysis . Arch Dermatol 110:103-104, 1974;.
33 +
Calloway JL, Tate WE:  Toxic epidermal necrolysis caused by "gin and tonic." Arch Dermatol 109:909, 1974;.
34 +
Lyell A:  A review of toxic epidermal necrolysis in Britain . Br J Dermatol 79:662-671, 1967;.
35 +
Lyell A:  Toxic epidermal necrolysis resembling scaling of the skin . Br J Dermatol 68:355-361, 1960;.
36 +
Lyell A, et al:  Outbreak of toxic epidermal necrolysis associated with staphylococci . Lancet 1:787-798, 1969;.
37 +
Peck GC, Herzig GP, Elias PM:  Toxic epidermal necrolysis in a patient with graft-vs-host reaction . Arch Dermatol 105:561-569, 1972;.
38 +
Amman AJ, et al:  Toxic epidermal necrolysis . Lancet 2:248-249, 1972;.
39 +
Billingham RE, Strelein JW:  TEN and homologous disease in hamsters . Arch Dermatol 98:528-539, 1968;.
40 +
Balner H, de Vries MJ, van Bekkum DW:  Secondary disease in rat radiation chimeras . J Natl Cancer Inst 32:419-459, 1964;.
41 +
Merritt CB, Darrow CC, Vaal L, et al:  Bone marrow transplantation on rhesus monkeys following irradiation . Transplantation 14:9-20, 1972;.
42 +
Whipper KD, Dimond RL, Knutson DD:  Studies of the mechanism of epidermal injury by a staphylococcal epidermolytic toxin . J Invest Dermatol 65:191-200, 1975;.
43 +
Strelein JW:  An analysis of epidermolysis in hamsters suffering from homologous disease , in Montagna W, Billingham RE (eds): Advances in Biology of Skin. vol 11, Immunology and the Skin . New York, Appleton-Century-Crofts, Inc, 1971;, pp 213-222.
44 +
Braun-Falco O, Wolff H:  Zur Ultrastruktur der Epidermis beim Lyell Syndrom . Arch Klin Exp Dermatol 236:83-96, 1969;.
45 +
Nasimann T, Lee S:  Electronenmikroskopische Befunde beim Lyell-Syndrom . Hautarzt 23:199-204, 1972;.
46 +
de Dobbeleer G, Achten G:  Staphylococcal Scalded Skin syndrome: An ultrastructural study . J Cutan Pathol 2:91-96, 1975;.
47 +
Ohlenschlaeger K:  Toxic epidermal necrolysis and Stevens Johnson disease . Acta Derm Venereol 46:205-209, 1966;.
48 +
Bjornberg A, Bjornberg K, Gisslen H:  Toxic epidermal necrolysis with ophthalmic complications . Acta Ophthalmol 42:1084-1095, 1964;.
49 +
Rousselst R, Labrum C:  Erythema multiforme (Stevens Johnson Syndrome) with dermatitis exfoliativa . Bull Soc Fr Dermatol Syphilol 71:672-675, 1964;.

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Lyell A:  Toxic epidermal necrolysis: An eruption resembling scalding of the skin . Br J Dermatol 68:355-361, 1956;.
2 +
Lang R, Walker J:  An unusual bullous eruption . S Arf Med J 30:97-98, 1956;.
3 +
Tyson RG, Ushinski SC, Kisilevsky R:  Toxic epidermal necrolysis (the scalded skin syndrome) . Am J Dis Child 111:386-392, 1966;.
4 +
Jefferson J:  Lyell's toxic epidermal necrolysis: A staphylococcal etiology . Br Med J 2:802-804, 1967;.
5 +
Lowney ED, Banblis JV, Kreye GM, et al:  The scalded skin syndrome in small children . Arch Dermatol 95:359-369, 1967;.
6 +
Koblenzer PJ:  Acute epidermal necrolysis (Ritter von Rittershain-Lyell) . Arch Dermatol 95:608-617, 1967;.
7 +
Ritter von Rittershain C:  Die exfoliative Dermatitis jungerer Sauglinge . Centralzeit Kinderheilkd 2:3-23, 1878;.
8 +
Sloss RG, Rayhanzadeh S:  Toxic epidermal necrolysis following measles vaccination . Arch Dermatol 110:766-770, 1974;.
9 +
Product information circular on thiabendazole. Merck, Sharp and Dohme.
10 +
Brown H:  The chemistry of thiabendazole . Tex Rep Biol Med 27:533-536, 1969;.
11 +
Eaton LG, Siegmund OH, Rankin AO, et al:  The veterinary uses of thiabendazole . Tex Rep Biol Med 27:697-708, 1969;.
12 +
Franz KH:  Clinical trials with thiabendazole against intestinal nematodes infecting humans . Am J Trop Med Hyg 14:383-386, 1965;.
13 +
Most H, Yoeli M, Campbell WC, et al:  The treatment of Strongyloides and Enterobius infection with thiabendazole . Am J Trop Med 14:379-382, 1965;.
14 +
Davis H:  Pinworm infestation-therapy with thiabendazole . Tex Rep Biol Med 27:623-627, 1969;.
15 +
Egerton JR:  The ovicidal and larvicidal effect of thiabendazole on various helminth species . Tex Rep Biol Med 27:561-580, 1969;.
16 +
Kotcher E, Chavarria AP, Gamboa JA, et al:  Community control of intestinal nematodes by thiabendazole treatment . Tex Rep Biol Med 27:629-643, 1969;.
17 +
Chuttani HK, Chouri MAK:  Thiabendazole and related compounds in treatment of hookworm infestation . Tex Rep Biol Med 27:597-600, 1969;.
18 +
Stone OJ:  Systemic and topical thiabendazole for creeping eruption . Tex Rep Biol Med 27:659-663, 1969;.
19 +
Battistini F:  Treatment of creeping eruption with topical thiabendazole . Tex Rep Biol Med 27:644-658, 1969;.
20 +
Hennekeuser HH, Pabst K, Poeplan W, et al:  Thiabendazole for the treatment of trichinosis in humans . Tex Rep Biol Med 27:581-596, 1969;.
21 +
Campbell WC, Cuckler AC:  Thiabendazole in the treatment and control of parasite infections in man . Tex Rep Biol Med 27:665-692, 1969;.
22 +
Franz KH:  Clinical trials of thiabendazole against human strongyloidiasis . Am J Trop Med Hyg 12:211-214, 1963;.
23 +
Salunkhe DS, Gaitorde BB, Vakil BJ:  Clinical evaluation of a new antihelmintic thiabendazole 2-(4′ thiazolyl) benzimidazole . Am J Trop Med 13:412-416, 1964;.
24 +
Stuart JE, Welch JS:  Treatment of trichinosis with thiabendazole . Med J Aust 2:1017-1019, 1973;.
25 +
Robinson HJ, Silber RH, Graessle OE:  Thiabendazole: Toxicological, pharmacological and antifungal properties . Tex Rep Biol Med 27:537-560, 1969;.
26 +
Katz R, Ziegler J, Blank H:  The natural course of creeping eruption and treatment with thiabendazole . Arch Dermatol 91:420-424, 1965;.
27 +
Stone OJ, Mullins JF:  Thiabendazole-effectiveness in creeping eruption . Arch Dermatol 91:427-429, 1965;.
28 +
Huang OH, Brown HSW:  The efficacy of thiabendazole against hookworm and ascaris of man . J Parsitol 49:1014-1018, 1963;.
29 +
Jacksonville Dermatologic Society:  Creeping eruption treatment with thiabendazole . Arch Dermatol 91:425-426, 1965;.
30 +
Kean BH, Hoskins DW:  Treatment of trichinosis with thiabendazole: A preliminary report . JAMA 190:852-853, 1964;.
31 +
Rist TE, Abele DC:  Current concepts of toxic epidermal necrolysis . South Med J 68:22-26, 1975;.
32 +
Radimer GF, Davis JH, Ackerman AB:  Fumigant induced toxic epidermal necrolysis . Arch Dermatol 110:103-104, 1974;.
33 +
Calloway JL, Tate WE:  Toxic epidermal necrolysis caused by "gin and tonic." Arch Dermatol 109:909, 1974;.
34 +
Lyell A:  A review of toxic epidermal necrolysis in Britain . Br J Dermatol 79:662-671, 1967;.
35 +
Lyell A:  Toxic epidermal necrolysis resembling scaling of the skin . Br J Dermatol 68:355-361, 1960;.
36 +
Lyell A, et al:  Outbreak of toxic epidermal necrolysis associated with staphylococci . Lancet 1:787-798, 1969;.
37 +
Peck GC, Herzig GP, Elias PM:  Toxic epidermal necrolysis in a patient with graft-vs-host reaction . Arch Dermatol 105:561-569, 1972;.
38 +
Amman AJ, et al:  Toxic epidermal necrolysis . Lancet 2:248-249, 1972;.
39 +
Billingham RE, Strelein JW:  TEN and homologous disease in hamsters . Arch Dermatol 98:528-539, 1968;.
40 +
Balner H, de Vries MJ, van Bekkum DW:  Secondary disease in rat radiation chimeras . J Natl Cancer Inst 32:419-459, 1964;.
41 +
Merritt CB, Darrow CC, Vaal L, et al:  Bone marrow transplantation on rhesus monkeys following irradiation . Transplantation 14:9-20, 1972;.
42 +
Whipper KD, Dimond RL, Knutson DD:  Studies of the mechanism of epidermal injury by a staphylococcal epidermolytic toxin . J Invest Dermatol 65:191-200, 1975;.
43 +
Strelein JW:  An analysis of epidermolysis in hamsters suffering from homologous disease , in Montagna W, Billingham RE (eds): Advances in Biology of Skin. vol 11, Immunology and the Skin . New York, Appleton-Century-Crofts, Inc, 1971;, pp 213-222.
44 +
Braun-Falco O, Wolff H:  Zur Ultrastruktur der Epidermis beim Lyell Syndrom . Arch Klin Exp Dermatol 236:83-96, 1969;.
45 +
Nasimann T, Lee S:  Electronenmikroskopische Befunde beim Lyell-Syndrom . Hautarzt 23:199-204, 1972;.
46 +
de Dobbeleer G, Achten G:  Staphylococcal Scalded Skin syndrome: An ultrastructural study . J Cutan Pathol 2:91-96, 1975;.
47 +
Ohlenschlaeger K:  Toxic epidermal necrolysis and Stevens Johnson disease . Acta Derm Venereol 46:205-209, 1966;.
48 +
Bjornberg A, Bjornberg K, Gisslen H:  Toxic epidermal necrolysis with ophthalmic complications . Acta Ophthalmol 42:1084-1095, 1964;.
49 +
Rousselst R, Labrum C:  Erythema multiforme (Stevens Johnson Syndrome) with dermatitis exfoliativa . Bull Soc Fr Dermatol Syphilol 71:672-675, 1964;.

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