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Cross-Sensitization Between Frullania and Laurus nobilis: The Allergen Laurel

Y. Asakawa, PhD; C. Benezra, PhD; G. Ducombs, MD; J. Foussereau, MD; J. C. Muller, PhD; G. Ourisson, PhD
[+] Author Affiliations

Strasbourg, France

Ottawa

Bordeaux, France

Strasbourg, France

Strasbourg, France

Strasbourg, France


Arch Dermatol. 1974;110(6):957-957. doi:10.1001/archderm.1974.01630120089026
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To the Editor.—  The essential oil extracted from the leaves of Laurus nobilis (L) is responsible for a number of allergic contact dermatitides.1 At the Consultation d'Allergologie et de Dermatoses Professionnelles of Strasbourg in France, this allergy represented 17.8% of the total allergic contact dermatitides to plants in the 1967-1972 statistics. Frullania. a liverwort commonly found in forests, growing on tree barks or even rocks in France,2-4 Scotland,5 and British Columbia, Canada,6 especially, is also known to cause allergic contact dermatitis. Two or three years ago in Strasbourg, it was found that patients allergic to Frullania were also allergic to the laurel essential oil extracted from the leaves. More recently, these cross-sensitizations were also found in Bordeaux, France, and in British Columbia (J. C. Mitchell, MD, written communication, March 1974).A number of allergens have been isolated from Frullania species.2-6 They all are α-mathylene γ-butyrolactone

REFERENCES

Foussereau J, Benezra C, Ourisson G:  Contact dermatitis from laurel-I . Trans St Johns Hosp Dermatol Soc 53:141, 1967;.
Le Coulant P, Texier L, Maleville J, et al:  L'allergie au Frullania: Son rôle dans la "dermite du bois de chêne." Bull Soc Fr Dermatol Syphiligr 73:440-443, 1966;.
Knoche H, Ourisson G, Perold GW, et al:  Allergenic component of a liverwort: A sesquiterpene lactone . Science 166:239, 1969;.
Perold GW, Muller JC, Ourisson G:  Structure d'une lactone allergisante: Le frullanolide-I . Tetrahedron 28:5797, 1972;.
Connolly JD, Thornton IMS:  Sesquiterpenoid lactones from the liverwort Frullania tamarisci . Phytochemistry 12:631, 1973;.
Mitchell JC, Fritig B, Singh B, et al:  Allergic contact dermatitis caused by Artemisia and Chrysanthemum species . J Invest Dermatol 54:233, 1970;.
Tada H, Takeda K:  Structure of the sesquiterpene lactone laurenobiolide . J Chem Soc Chem Comm , 1971;, p 1391.
Foussereau J, Benezra C, Ourisson G:  Contact dermatitis from laurel-II . Trans St Johns Hosp Dermatol Soc 53:147, 1967;.
Mitchell JC, Geissman TA, Dupuis G, et al:  Allergic contact dermatitis caused by Artemisia and Chrysanthemum species . J Invest Dermatol 56:98, 1971;.

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Foussereau J, Benezra C, Ourisson G:  Contact dermatitis from laurel-I . Trans St Johns Hosp Dermatol Soc 53:141, 1967;.
Le Coulant P, Texier L, Maleville J, et al:  L'allergie au Frullania: Son rôle dans la "dermite du bois de chêne." Bull Soc Fr Dermatol Syphiligr 73:440-443, 1966;.
Knoche H, Ourisson G, Perold GW, et al:  Allergenic component of a liverwort: A sesquiterpene lactone . Science 166:239, 1969;.
Perold GW, Muller JC, Ourisson G:  Structure d'une lactone allergisante: Le frullanolide-I . Tetrahedron 28:5797, 1972;.
Connolly JD, Thornton IMS:  Sesquiterpenoid lactones from the liverwort Frullania tamarisci . Phytochemistry 12:631, 1973;.
Mitchell JC, Fritig B, Singh B, et al:  Allergic contact dermatitis caused by Artemisia and Chrysanthemum species . J Invest Dermatol 54:233, 1970;.
Tada H, Takeda K:  Structure of the sesquiterpene lactone laurenobiolide . J Chem Soc Chem Comm , 1971;, p 1391.
Foussereau J, Benezra C, Ourisson G:  Contact dermatitis from laurel-II . Trans St Johns Hosp Dermatol Soc 53:147, 1967;.
Mitchell JC, Geissman TA, Dupuis G, et al:  Allergic contact dermatitis caused by Artemisia and Chrysanthemum species . J Invest Dermatol 56:98, 1971;.

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