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Correspondence |

Septic Facial Vein Thrombosis Due to Panton-Valentine Leukocidin–Positive Staphylococcus aureus

Norah Kramkimel, MD; Emilie Sbidian, MD; Tu Anh Duong, MD; Philippe Lesprit, MD; Jean-Claude Roujeau, PhD, MD; Martine Bagot, PhD, MD
Arch Dermatol. 2009;145(12):1460-1461. doi:10.1001/archdermatol.2009.317.
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Facial malignant staphylococcal infection is a rare infectious disorder characterized by a septic facial venous thrombosis. Herein we report the first case to our knowledge in a healthy young woman due to Panton-Valentine leukocidin (PVL)–positive Staphylococcus aureus.

Ayadi  KMehdi  MKhannous  M  et al Septic thrombosis of the cavernous sinus complicating malignant staphylococcal infection of the face. J Radiol1995768497499
Gillet  YIssartel  BVanhems  P  et al Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients. Lancet20023599308753759
Holmes  AGanner  M McGuane  SPitt  TLCookson  BDKearns  AM Staphylococcus aureus isolates carrying Panton-Valentine leucocidin genes in England and Wales: frequency, characterization, and association with clinical disease. J Clin Microbiol200543523842390
Sinha  BHerrmann  M Mechanism and consequences of invasion of endothelial cells by Staphylococcus aureusThromb Haemost2005942266277
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Figure 1. Marked facial edema with predominance about the periorbital region, especially of the right eye (A) and total recovery after treatment (B).

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Figure 2. Computed tomography images. A and B, Important infiltration of facial soft tissues and filling defects of the bilateral facial veins (arrow). C, Filling defects of the right superior ophthalmic vein (left arrow); the left superior ophthalmic vein is permeable (right arrow).

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