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Correspondence |

Leukonychia Related to Vorinostat

Kyle A. Anderson, MD; Holly L. Bartell, MD; Elise A. Olsen, MD
Arch Dermatol. 2009;145(11):1338-1339. doi:10.1001/archdermatol.2009.272.
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We herein describe a new clinical finding of leukonychia occurring in 3 patients with mycosis fungoides (MF) being treated with vorinostat (Zolinza; Merck & Co Inc, Whitehouse Station, New Jersey), a zinc-dependent histone deacetylase (HDAC) inhibitor approved for the treatment of cutaneous T-cell lymphoma.1

Olsen  EAKim  YHKuzel  TM  et al.  Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma. J Clin Oncol 2007;25 (21) 3109- 3115
PubMed Link to Article[[XSLOpenURL/10.1200/JCO.2006.10.2434]]
Grossman  MScher  RK Leukonychia: review and classification. Int J Dermatol 1990;29 (8) 535- 541
PubMed Link to Article[[XSLOpenURL/10.1111/ijd.1990.29.issue-8]]
Stevens  KRLeis  PPeters  SBaer  SOrengo  I Congenital leukonychia. J Am Acad Dermatol 1998;39 (3) 509- 512
PubMed Link to Article[[XSLOpenURL/10.1016/S0190-9622(98)70341-X]]
Daniel  CR  IIIZaias  N Pigmentary abnormalities of the nails with emphasis on systemic diseases. Dermatol Clin 1988;6 (2) 305- 313
Rössig  LLi  HFisslthaler  B  et al.  Inhibitors of histone deacetylation downregulate the expression of endothelial nitric oxide synthase and compromise endothelial cell function in vasorelaxation and angiogenesis. Circ Res 2002;91 (9) 837- 844
PubMed Link to Article[[XSLOpenURL/10.1161/01.RES.0000037983.07158.B1]]
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Figure 1

Clinical comparison of the fingernails of patient 1 after 6 months of vorinostat treatment (top, 2 hands) with normal fingernails (bottom, 1 hand).

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Figure 2

Clinical appearance of the fingernails of patient 2 after 10 months of vorinostat treatment.

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Leukonychia related to vorinostat. Arch Dermatol 2009;145(11):1338-9.