Venous malformations (VMs) are among the most common vascular malformations, second in frequency only to port-wine stains, and they are the most common vascular malformations seen in multidisciplinary vascular anomalies referral centers.1 They are structural anomalies of the venous vasculature that are composed of ectatic or aberrant venous channels deficient in smooth muscle cells. Most VMs are evident at birth, but a notable minority of patients present for the first time later in childhood or as adults. Although not a tumor per se,2 VMs may expand disproportionately to somatic growth. Some cases, both hereditary and sporadic, are due to mutations in Tie-2, an endothelial cell tyrosine kinase receptor, but many VMs do not show this mutation and are presumably due to other somatic or germ-line mutations. The concept of ongoing clotting within VMs is not new3,4; however, an increased appreciation of the significance of clotting, its associated coagulopathy, and its delineation from Kasabach-Merritt phenomenon is relatively recent. Two reports in the Archives in 2008 helped to further characterize this coagulopathy.5,6
Thank you for submitting a comment on this article. It will be reviewed by JAMA Dermatology editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 6
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
The Rational Clinical Examination
All results at
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.