Correspondence |

Acute Generalized Exanthematous Pustulosis Caused by Rifabutin

Chih-Pin Chen, MD; Yung-Hsiang Hsu, MD; Song-Jen Hong, MD
Arch Dermatol. 2009;145(9):1069-1070. doi:10.1001/archdermatol.2009.221.
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Acute generalized exanthematous pustulosis (AGEP), first named by Beylot et al1 in 1980, is a clinical reaction pattern that is principally drug induced.2,3 Its incidence is probably underestimated because many cases are either unrecognized or confused with pustular psoriasis.3 We report herein a case of AGEP caused by rifabutin, an antituberculous agent.

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Figure 1

Numerous nonfollicular pinhead sterile pustules on edematous and erythematous plaques over trunk and all extremities.

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Figure 2

Spongiform subcorneal pustule with mixed neutrophils and eosinophils and a focal necrosis of keratinocytes in the epidermis (hematoxylin-eosin, original magnification ×100).

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