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Correspondence |

Secondary Cutaneous Vasculitislike MALT Lymphoma With an IGL-MYC Fusion

Kjell Matthias Kaune, MD; Mario Baumgart, MSc; Stefan Gesk, MD; Peter Middel, MD; B. Michael Ghadimi, MD; Reiner Siebert, MD; Hans Peter Bertsch, MD; Michael Peter Schön, MD; Christine Neumann, MD
Arch Dermatol. 2009;145(8):955-958. doi:10.1001/archdermatol.2009.166.
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Mitelman  F ISCN 1995: An International System for Human Cytogenetic Nomenclature.  Basel, Switzerland: S Karger; 1995
Martíin-Subero  JIHarder  LGesk  S  et al.  Interphase FISH assays for the detection of translocations with breakpoints in immunoglobulin light chain loci. Int J Cancer 2002;98 (3) 470- 474
PubMed Link to Article[[XSLOpenURL/10.1002/(ISSN)1097-0215]]
Hallermann  CKaune  KMGesk  S  et al.  Molecular cytogenetic analysis of chromosomal breakpoints in the IGH, MYC, BCL6, and MALT1 gene loci in primary cutaneous B-cell lymphomas. J Invest Dermatol 2004;123 (1) 213- 219
PubMed Link to Article[[XSLOpenURL/10.1111/jid.2004.123.issue-1]]
Streubel  BSimonitsch-Klupp  IMüllauer  L  et al.  Variable frequencies of MALT lymphoma-associated genetic aberrations in MALT lymphomas of different sites. Leukemia 2004;18 (10) 1722- 1726
PubMed Link to Article[[XSLOpenURL/10.1038/sj.leu.2403501]]
van Krieken  JHRaffeld  MRaghoebier  SJaffe  ESvan Ommen  GJKluin  PM Molecular genetics of gastrointestinal non-Hodgkin's lymphomas: unusual prevalence and pattern of c-myc rearrangements in aggressive lymphomas. Blood 1990;76 (4) 797- 800
Kandula  PKouides  PA Rituximab-induced leukocytoclastic vasculitis: a case report. Arch Dermatol 2006;142 (2) 246- 247
PubMed Link to Article[[XSLOpenURL/10.1001/archderm.142.2.246]]
Deutsch  AJAigelsreiter  ASteinbauer  E  et al.  Distinct signatures of B-cell homeostatic and activation-dependent chemokine receptors in the development and progression of extragastric MALT lymphomas. J Pathol 2008;215 (4) 431- 444
PubMed Link to Article[[XSLOpenURL/10.1002/path.2372]]
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Figure 1.

Clinical and histopathologic case photographs. The patient displayed purpuric papules on his hips resembling allergic vasculitis (A and B) and bluish reticular indurations on his upper arms resembling livedo reticularis (C and D). E, Perivascular and periadnexal nodular infiltrates of densely packed monomorphic lymphocytes with many erythrocytes admixed are seen in a skin section from the arm; the infiltrate extends to the subcutaneous fat tissue (hematoxylin-eosin, original magnification ×20 for primary photograph and ×400 for the insert). Giemsa stain reveals prominent nuclei and a pale cytoplasm of the tumor cells (F) (original magnification ×600), which express CD20 (G) and CXC receptor 4 (H) (original magnification ×200 for both G and H); besides cytoplasmic staining, the nuclei of many tumor cells are positive for CXC receptor 4.

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Figure 2.

Fluorescence in situ hybridization (FISH). We performed FISH on paraffin-embedded lesional tissue sections and evaluated at least 200 nuclei. A, Interphase nuclei hybridized with the Locus Specific Identifier MYC break-apart probe (Abbott Molecular, Des Plaines, Illinois). The 2 nuclei show 1 intact MYC allele with a colocalization of the red (MYC proximal) and green (MYC distal) signals, and a dissociation of the green and red signals (arrows) indicating that MYC is involved in a translocation. B, Interphase nuclei hybridized with an IGL break-apart probe (as described in Martíin-Subero et al2). The 2 nuclei display a significant dissociation of the red (IGL proximal) and green (IGL distal) signals (arrows) indicating the presence of a translocation affecting the IGL. C, Interphase nuclei hybridized with an IGL/MYC dual-color, dual-fusion probe: red signal, 8q24 (MYC locus); green signal, 22q11 (IGL locus). The presence of fused red and green signals (arrows) indicate that an IGL/MYC fusion due to a translocation t(8;22)(q24;q11) has taken place. The isolated red and green signals point to the unrearranged MYC and IGL alleles, respectively.

Graphic Jump Location




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